ES470917A1 - Ÿun procedimiento para la preparacion de derivados de dihi- dropiridinaŸ - Google Patents

Ÿun procedimiento para la preparacion de derivados de dihi- dropiridinaŸ

Info

Publication number
ES470917A1
ES470917A1 ES470917A ES470917A ES470917A1 ES 470917 A1 ES470917 A1 ES 470917A1 ES 470917 A ES470917 A ES 470917A ES 470917 A ES470917 A ES 470917A ES 470917 A1 ES470917 A1 ES 470917A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
alkoxy
hydrogen
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470917A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES470917A1 publication Critical patent/ES470917A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación de derivados dihidropiridina de fórmula I, **(Fórmula)** en donde R1 es hidrógeno, alquilo de 1 a 6 átomos de carbono, alquenilo o alquinilo de 3 a 6 átomos de carbono, cicloalquilo de 3 a 7 átomos de carbono, cicloalquilalquilo de 4 a 8 átomos de carbono, fenilalquilo de 7 a 9 átomos de carbono o fenilalquenilo de 9 a 12 átomos de carbono R2 y R5, independientemente, son hidrógeno o alquilo de 1 a 6 átomos de carbono, R3 y R4, independientemente, son alquilo de 1 a 6 átomos de carbono, alquenilo o alquinilo de 3 a 6 átomos de carbono, cicloalquilo de 3 a 7 átomos de carbono, cicloalquilalquilo de 4 a 8 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, hidroxialcoxi de 2 a 6 átomos de carbono, alcoxialcoxi de 3 a 6 átomos de carbono, hidroxialcoxialcoxi de 4 a 8 átomos de carbono, alqueniloxi o alquiniloxi de 3 a 6 átomos de carbono, cicloalquiloxi de 3 a 7 átomos de carbono o cicloalquilalcoxi de 4 a 8 átomos de carbono, R6 es hidrógeno, halógeno, alquilo o alcoxi o alquiltio o alquilsulfonilo, cada uno de 1 a 4 átomos de carbono, trifluometilo, nitro o hidroxi, y X es oxígeno o azufre.
ES470917A 1977-06-20 1978-06-19 Ÿun procedimiento para la preparacion de derivados de dihi- dropiridinaŸ Expired ES470917A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH752077 1977-06-20
CH286578 1978-03-16

Publications (1)

Publication Number Publication Date
ES470917A1 true ES470917A1 (es) 1979-10-01

Family

ID=25691589

Family Applications (1)

Application Number Title Priority Date Filing Date
ES470917A Expired ES470917A1 (es) 1977-06-20 1978-06-19 Ÿun procedimiento para la preparacion de derivados de dihi- dropiridinaŸ

Country Status (20)

Country Link
EP (1) EP0000150B1 (es)
JP (1) JPS54103876A (es)
AT (1) AT376220B (es)
AU (1) AU524000B2 (es)
CA (1) CA1105463A (es)
CY (1) CY1239A (es)
DE (1) DE2860708D1 (es)
DK (1) DK149855C (es)
ES (1) ES470917A1 (es)
FI (1) FI64938C (es)
HK (1) HK65184A (es)
IE (1) IE47212B1 (es)
IL (1) IL54948A (es)
IT (1) IT1105364B (es)
LU (1) LU88342I2 (es)
MY (1) MY8500041A (es)
NL (1) NL930126I2 (es)
NZ (1) NZ187617A (es)
PT (1) PT68191A (es)
SG (1) SG20584G (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH639659A5 (de) * 1978-12-18 1983-11-30 Sandoz Ag Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
DK525179A (da) * 1978-12-18 1980-06-19 Sandoz Ag Fremgangsmaade til fremstilling af benzoxadiazoler og benzothiazoler
BE886259A (fr) * 1979-11-23 1981-05-20 Sandoz Sa Nouveaux medicament a base de derives de la 1,4-dihydropyridine, pour le traitement de l'insuffisance cerebrovasculaire ou a action spamolytique
CH655658B (es) * 1980-09-18 1986-05-15
FI813460L (fi) * 1980-11-10 1982-05-11 Sandoz Ag Nya 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-pyridinderivat deras framstaellningsfoerfarande och dessa innehaollande farmaceutiska kompositioner
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
FR2554109A1 (fr) * 1983-11-01 1985-05-03 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation en therapeutique comme medicaments
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
HU198844B (en) * 1984-06-14 1989-12-28 Sandoz Ag Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
GB8428552D0 (en) * 1984-11-12 1984-12-19 Sandoz Ltd Organic compounds
GB8616047D0 (en) * 1986-07-01 1986-08-06 Sandoz Ltd A 1 4-dihydropyridine derivatives
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Also Published As

Publication number Publication date
FI781867A (fi) 1978-12-21
AU524000B2 (en) 1982-08-26
EP0000150B1 (en) 1981-05-20
JPS6360755B2 (es) 1988-11-25
CY1239A (en) 1984-06-29
LU88342I2 (fr) 1994-05-04
DK149855B (da) 1986-10-13
FI64938C (fi) 1984-02-10
NZ187617A (en) 1980-12-19
NL930126I2 (nl) 1995-02-16
PT68191A (fr) 1978-07-01
FI64938B (fi) 1983-10-31
DK149855C (da) 1987-04-21
AT376220B (de) 1984-10-25
AU3725278A (en) 1980-01-03
SG20584G (en) 1985-03-08
IT1105364B (it) 1985-10-28
IL54948A0 (en) 1978-08-31
IE781231L (en) 1978-12-20
HK65184A (en) 1984-08-31
IE47212B1 (en) 1984-01-25
DE2860708D1 (en) 1981-08-27
DK262578A (da) 1978-12-21
ATA443178A (de) 1984-03-15
NL930126I1 (nl) 1993-11-01
CA1105463A (en) 1981-07-21
IT7849939A0 (it) 1978-06-19
EP0000150A1 (en) 1979-01-10
IL54948A (en) 1982-01-31
MY8500041A (en) 1985-12-31
JPS54103876A (en) 1979-08-15

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