GB0505781D0 - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
GB0505781D0
GB0505781D0 GBGB0505781.5A GB0505781A GB0505781D0 GB 0505781 D0 GB0505781 D0 GB 0505781D0 GB 0505781 A GB0505781 A GB 0505781A GB 0505781 D0 GB0505781 D0 GB 0505781D0
Authority
GB
United Kingdom
Prior art keywords
chemical compounds
compounds
isocladribine
clofarabine
cladribine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0505781.5A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Cardiff Consultants Ltd
Cardiff University
Original Assignee
University College Cardiff Consultants Ltd
Cardiff University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cardiff Consultants Ltd, Cardiff University filed Critical University College Cardiff Consultants Ltd
Priority to GBGB0505781.5A priority Critical patent/GB0505781D0/en
Publication of GB0505781D0 publication Critical patent/GB0505781D0/en
Priority to EP06710096A priority patent/EP1866324B1/en
Priority to AU2006226182A priority patent/AU2006226182C1/en
Priority to CNA200680016708XA priority patent/CN101175763A/zh
Priority to DE602006014949T priority patent/DE602006014949D1/de
Priority to MX2007011666A priority patent/MX2007011666A/es
Priority to PT06710096T priority patent/PT1866324E/pt
Priority to CN201410186829.5A priority patent/CN103936807A/zh
Priority to BRPI0609704A priority patent/BRPI0609704B8/pt
Priority to CA2602324A priority patent/CA2602324C/en
Priority to PL06710096T priority patent/PL1866324T3/pl
Priority to ZA200709011A priority patent/ZA200709011B/xx
Priority to DK06710096.6T priority patent/DK1866324T3/da
Priority to US11/886,931 priority patent/US8263575B2/en
Priority to PCT/GB2006/000932 priority patent/WO2006100439A1/en
Priority to AT06710096T priority patent/ATE471334T1/de
Priority to JP2008502453A priority patent/JP5345381B2/ja
Priority to ES06710096T priority patent/ES2348741T3/es
Priority to SI200630762T priority patent/SI1866324T1/sl
Priority to IL186104A priority patent/IL186104A/en
Priority to CY20101100826T priority patent/CY1111538T1/el
Priority to JP2013097919A priority patent/JP5863702B2/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB0505781.5A 2005-03-21 2005-03-21 Chemical compounds Ceased GB0505781D0 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GBGB0505781.5A GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds
SI200630762T SI1866324T1 (sl) 2005-03-21 2006-03-16 Fosforamidni derivati nukleotidnih sestavkov za uporabo pri zdravljenju raka
PL06710096T PL1866324T3 (pl) 2005-03-21 2006-03-16 Fosforamidanowe pochodne związków nukleozydowych do stosowania przy leczeniu raka
DK06710096.6T DK1866324T3 (da) 2005-03-21 2006-03-16 Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer
CNA200680016708XA CN101175763A (zh) 2005-03-21 2006-03-16 用于治疗癌症的核苷化合物的氨基磷酸酯衍生物
DE602006014949T DE602006014949D1 (de) 2005-03-21 2006-03-16 Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs
MX2007011666A MX2007011666A (es) 2005-03-21 2006-03-16 Derivados de fosforamidato de compuestos nucleosidicos para el uso en el tratamiento del cancer.
PT06710096T PT1866324E (pt) 2005-03-21 2006-03-16 Derivados de fosforamidato de compostos de nucleósido para utilização no tratamento do cancro
CN201410186829.5A CN103936807A (zh) 2005-03-21 2006-03-16 用于治疗癌症的核苷化合物的氨基磷酸酯衍生物
BRPI0609704A BRPI0609704B8 (pt) 2005-03-21 2006-03-16 compostos derivados de fosforamidato, seus usos, composições farmacêuticas que os compreendem, métodos de preparação das referidas composições e processo para preparação de um composto
CA2602324A CA2602324C (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
EP06710096A EP1866324B1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
ZA200709011A ZA200709011B (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
AU2006226182A AU2006226182C1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
US11/886,931 US8263575B2 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
PCT/GB2006/000932 WO2006100439A1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
AT06710096T ATE471334T1 (de) 2005-03-21 2006-03-16 Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs
JP2008502453A JP5345381B2 (ja) 2005-03-21 2006-03-16 癌の治療における使用のためのヌクレオシド化合物のホスホルアミデート誘導体
ES06710096T ES2348741T3 (es) 2005-03-21 2006-03-16 Derivados de fosforamidato de compuestos nucleosidos para uso en el tratamiento del cancer.
IL186104A IL186104A (en) 2005-03-21 2007-09-20 Phosphoramidate History of Nucleoside Compounds
CY20101100826T CY1111538T1 (el) 2005-03-21 2010-09-10 Φωσφοραμιδικα παραγωγα νουκλεοζιτικων ενωσεων για χρηση στην αντιμετωπιση καρκινου
JP2013097919A JP5863702B2 (ja) 2005-03-21 2013-05-07 癌の治療における使用のためのヌクレオシド化合物のホスホルアミデート誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0505781.5A GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds

Publications (1)

Publication Number Publication Date
GB0505781D0 true GB0505781D0 (en) 2005-04-27

Family

ID=34531603

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0505781.5A Ceased GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds

Country Status (20)

Country Link
US (1) US8263575B2 (US20080131398A1-20080605-C00009.png)
EP (1) EP1866324B1 (US20080131398A1-20080605-C00009.png)
JP (2) JP5345381B2 (US20080131398A1-20080605-C00009.png)
CN (2) CN103936807A (US20080131398A1-20080605-C00009.png)
AT (1) ATE471334T1 (US20080131398A1-20080605-C00009.png)
AU (1) AU2006226182C1 (US20080131398A1-20080605-C00009.png)
BR (1) BRPI0609704B8 (US20080131398A1-20080605-C00009.png)
CA (1) CA2602324C (US20080131398A1-20080605-C00009.png)
CY (1) CY1111538T1 (US20080131398A1-20080605-C00009.png)
DE (1) DE602006014949D1 (US20080131398A1-20080605-C00009.png)
DK (1) DK1866324T3 (US20080131398A1-20080605-C00009.png)
ES (1) ES2348741T3 (US20080131398A1-20080605-C00009.png)
GB (1) GB0505781D0 (US20080131398A1-20080605-C00009.png)
IL (1) IL186104A (US20080131398A1-20080605-C00009.png)
MX (1) MX2007011666A (US20080131398A1-20080605-C00009.png)
PL (1) PL1866324T3 (US20080131398A1-20080605-C00009.png)
PT (1) PT1866324E (US20080131398A1-20080605-C00009.png)
SI (1) SI1866324T1 (US20080131398A1-20080605-C00009.png)
WO (1) WO2006100439A1 (US20080131398A1-20080605-C00009.png)
ZA (1) ZA200709011B (US20080131398A1-20080605-C00009.png)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
AU2012216500B2 (en) * 2006-11-24 2013-06-20 Katholieke Universiteit Leuven Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus
GB0623493D0 (en) 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
PA8855701A1 (es) 2008-12-23 2010-07-27 Análogos de nucleósidos
WO2010075554A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Synthesis of purine nucleosides
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
KR20110120886A (ko) 2009-01-09 2011-11-04 유니버시티 칼리지 오브 카디프 컨설턴트 리미티드 바이러스 감염 치료용 구아노신 뉴클레오사이드 화합물의 포스포라미데이트 유도체
BR112012024884A2 (pt) 2010-03-31 2016-10-18 Gilead Pharmasset Llc síntese estereosseletiva de ativos contendo fósforo
GB201016855D0 (en) * 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
WO2012092484A2 (en) * 2010-12-29 2012-07-05 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
CN103403014B (zh) * 2011-01-03 2016-07-06 河南美泰宝生物制药有限公司 O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途
DK3031812T3 (en) 2011-03-01 2018-09-17 NuCana plc CHEMICAL COMPOUNDS
US9085599B2 (en) 2011-03-16 2015-07-21 Enanta Pharmaceuticals, Inc. 2′allene-substituted nucleoside derivatives
CN111592577A (zh) * 2012-11-16 2020-08-28 努卡那公共有限公司 用于制备核苷前体药物的方法
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
AU2014354775A1 (en) 2013-11-27 2016-05-19 Idenix Pharmaceuticals Llc Nucleotides for the treatment of liver cancer
KR20170005492A (ko) * 2014-05-28 2017-01-13 아이데닉스 파마슈티칼스 엘엘씨 암의 치료를 위한 뉴클레오시드 유도체
EP3149017B1 (en) * 2014-05-28 2019-12-11 Idenix Pharmaceuticals LLC Nucleoside derivatives for the treatment of cancer
IL291927A (en) 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
KR20220025914A (ko) 2015-03-06 2022-03-03 아테아 파마슈티컬즈, 인크. HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
BR112018009946A8 (pt) 2015-11-16 2019-02-26 Ichorion Therapeutics Inc pró-fármacos de ácido nucleico
GB201522764D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609602D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
CN116036114A (zh) 2016-09-07 2023-05-02 阿堤亚制药公司 用于rna病毒治疗的2’-取代的-n6-取代的嘌呤核苷酸
WO2018071675A1 (en) * 2016-10-12 2018-04-19 Georgetown University Cd99 inhibitors and their uses
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
GB201904544D0 (en) 2019-04-01 2019-05-15 NuCana plc Anticancer compounds
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN113549076B (zh) * 2021-07-23 2022-12-06 中国药科大学 一种多取代嘌呤类化合物及其制备方法和应用

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KR880000094B1 (ko) 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
CA2004695C (en) 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipid nucleosides
DE4418690A1 (de) 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
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CA2675757C (en) 1995-04-21 2011-03-15 University Of South Florida Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof
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JP4768909B2 (ja) 2000-09-29 2011-09-07 扶桑薬品工業株式会社 トポイソメラーゼ阻害剤
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Also Published As

Publication number Publication date
CA2602324C (en) 2015-02-24
IL186104A0 (en) 2008-01-20
JP5345381B2 (ja) 2013-11-20
WO2006100439A1 (en) 2006-09-28
IL186104A (en) 2013-06-27
BRPI0609704B8 (pt) 2021-09-28
EP1866324A1 (en) 2007-12-19
DE602006014949D1 (de) 2010-07-29
US8263575B2 (en) 2012-09-11
AU2006226182B2 (en) 2011-09-01
AU2006226182A1 (en) 2006-09-28
BRPI0609704B1 (pt) 2020-12-01
ATE471334T1 (de) 2010-07-15
JP5863702B2 (ja) 2016-02-17
DK1866324T3 (da) 2010-09-27
AU2006226182C1 (en) 2012-06-14
CN101175763A (zh) 2008-05-07
PT1866324E (pt) 2010-09-16
CN103936807A (zh) 2014-07-23
SI1866324T1 (sl) 2010-10-29
MX2007011666A (es) 2007-11-14
CA2602324A1 (en) 2006-09-28
JP2008533191A (ja) 2008-08-21
US20090215715A1 (en) 2009-08-27
CY1111538T1 (el) 2015-08-05
EP1866324B1 (en) 2010-06-16
JP2013173786A (ja) 2013-09-05
ZA200709011B (en) 2009-01-28
PL1866324T3 (pl) 2010-12-31
BRPI0609704A2 (pt) 2010-04-20
ES2348741T3 (es) 2010-12-13

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)