FR2962911A1 - Composition pharmaceutique d'association destinee a etre utilisee dans un procede pour traiter le trouble d'hyperactivite avec deficit de l'attention - Google Patents
Composition pharmaceutique d'association destinee a etre utilisee dans un procede pour traiter le trouble d'hyperactivite avec deficit de l'attention Download PDFInfo
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- FR2962911A1 FR2962911A1 FR1156478A FR1156478A FR2962911A1 FR 2962911 A1 FR2962911 A1 FR 2962911A1 FR 1156478 A FR1156478 A FR 1156478A FR 1156478 A FR1156478 A FR 1156478A FR 2962911 A1 FR2962911 A1 FR 2962911A1
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Landscapes
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- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010130358/15A RU2519695C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство для лечения синдрома дефицита внимания и способ лечения синдрома дефицита внимания |
| RU2011127055/15A RU2536230C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для лечения неврологическо-поведенческих рассторойств развития и способ лечения неврологическо-поведенческих расстройств развития |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2962911A1 true FR2962911A1 (fr) | 2012-01-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1156478A Withdrawn FR2962911A1 (fr) | 2010-07-21 | 2011-07-15 | Composition pharmaceutique d'association destinee a etre utilisee dans un procede pour traiter le trouble d'hyperactivite avec deficit de l'attention |
Country Status (16)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| WO2012007845A2 (en) * | 2010-07-15 | 2012-01-19 | Oleg Iliich Epshtein | A method of increasing the effect of an activated-potentiated form of an antibody |
| ES2542042R1 (es) | 2010-07-15 | 2015-10-06 | Oleg Iliich Epshtein | Composiciones farmacéuticas y uso para preparar un medicamento destinado al tratamiento de la obesidad, los trastornos metabólicos relacionados y la adicción a sustancias psicoactivas |
| US8637034B2 (en) | 2010-07-15 | 2014-01-28 | Oleg I. Epshtein | Pharmaceutical compositions comprising activated-potentiated antibodies to interferon-gamma and S100 protein |
| KR20130102542A (ko) * | 2010-07-21 | 2013-09-17 | 올레그 일리치 엡쉬테인 | 현기증, 동요병 및 증식형-혈관 이긴장증 치료용 제약학적 복합 조성물 및 치료 방법들 |
| CN103119061A (zh) | 2010-07-21 | 2013-05-22 | 奥列格·伊里奇·爱泼斯坦 | 治疗注意力不足过动症的方法 |
| RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901967A (en) | 1973-09-10 | 1975-08-26 | Union Corp | Sustained release of atropine |
| US4311897A (en) | 1979-08-28 | 1982-01-19 | Union Carbide Corporation | Plasma arc torch and nozzle assembly |
| US4963367A (en) | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| RU2007989C1 (ru) | 1991-11-12 | 1994-02-28 | Акционерное общество "Трейдис" | Способ габович подбора гомеопатических препаратов и их разовой дозы |
| US5879677A (en) | 1992-12-09 | 1999-03-09 | The Scripps Research Institute | Method for inhibition of cerebral tissue factor mediated reperfusion damage |
| RU2033784C1 (ru) | 1993-05-28 | 1995-04-30 | Индивидуальное частное предприятие "Диалог" | Устройство для репродуцирования гомеопатических и изопатических препаратов |
| US5895783A (en) | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
| IT1261849B (it) | 1993-09-02 | 1996-06-03 | Avantgarde Spa | Dispositivo medico per la somministrazione di principi attivi o farmaci a bassissimo dosaggio, in particolare di farmaci omeopatici. |
| BR9507200A (pt) | 1994-03-25 | 1997-09-16 | Isotechnika Inc | Melhora da eficácia de drogas por deuteração |
| IL110035A0 (en) | 1994-06-16 | 1994-10-07 | Tapuach Natural Technologies 1 | Homeopathic formulations |
| CA2251617A1 (en) | 1996-02-12 | 1997-08-14 | Oleg Iliich Epshtein | Medicament and method of treating an organism with medicaments |
| US6150500A (en) | 1996-07-12 | 2000-11-21 | Salerno; John C. | Activators of endothelial nitric oxide synthase |
| RU2114605C1 (ru) | 1996-09-30 | 1998-07-10 | Олег Ильич Эпштейн | Защитная добавка для косметических средств |
| RU2114646C1 (ru) | 1996-09-30 | 1998-07-10 | Олег Ильич Эпштейн | Способ повышения защитных свойств организма при воздействии внешних физических факторов |
| RU2104032C1 (ru) | 1997-03-11 | 1998-02-10 | Общество с ограниченной ответственностью "Снежный барс" | Способ усиления лечебного эффекта лекарственных средств |
| US5849528A (en) | 1997-08-21 | 1998-12-15 | Incyte Pharmaceuticals, Inc.. | Polynucleotides encoding a human S100 protein |
| WO1999026657A1 (en) | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| CN1160079C (zh) | 1998-03-11 | 2004-08-04 | 格勒兰制药株式会社 | 发泡性肠溶制剂 |
| RU2187334C2 (ru) | 1998-05-22 | 2002-08-20 | Эпштейн Олег Ильич | Способ коррекции нарушенного иммунного гомеостаза и лекарственное средство |
| RU2156621C1 (ru) | 1999-03-04 | 2000-09-27 | Эпштейн Олег Ильич | Нейротропное лекарственное средство |
| RU2161955C1 (ru) | 1999-07-16 | 2001-01-20 | Эпштейн Олег Ильич | Способ изменения физико-химических или физико-химических и биологических свойств вещества |
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| RU2192882C1 (ru) | 2001-04-18 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения |
| RU2201255C1 (ru) | 2001-12-26 | 2003-03-27 | Эпштейн Олег Ильич | Лекарственное средство и способ регуляции сосудистого тонуса |
| UA76641C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування захворювань передміхурової залози |
| UA76640C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
| UA76639C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
| UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| CN101107003B (zh) | 2003-03-14 | 2012-08-08 | 营养学研究有限公司 | 用于治疗疼痛和/或炎症的顺势疗法的配剂 |
| RU2253478C1 (ru) | 2003-10-01 | 2005-06-10 | Эпштейн Олег Ильич | Средство для потенцирования лечебных эффектов - усиления действия лекарственного вещества |
| RU2309732C1 (ru) | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| RU2438707C2 (ru) * | 2006-06-06 | 2012-01-10 | Олег Ильич Эпштейн | Лекарственное средство для перорального лечения сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе, и способ получения твердой лекарственной формы для пероральной терапии сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе |
| WO2007149010A1 (en) | 2006-06-06 | 2007-12-27 | Oleg Iliich Epshtein | Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance |
| US20130189707A1 (en) | 2010-01-26 | 2013-07-25 | Svetlana Alexandrovna Sergeeva | Method of determination of autoantibody level by means of enzyme immunoassay |
| MY157564A (en) | 2010-07-15 | 2016-06-30 | Epshtein Oleg Lliich | Combination pharmaceutical composition and methods of treating functional diseases or conditions of gastrointestinal tract |
| ES2542042R1 (es) | 2010-07-15 | 2015-10-06 | Oleg Iliich Epshtein | Composiciones farmacéuticas y uso para preparar un medicamento destinado al tratamiento de la obesidad, los trastornos metabólicos relacionados y la adicción a sustancias psicoactivas |
| US8637034B2 (en) | 2010-07-15 | 2014-01-28 | Oleg I. Epshtein | Pharmaceutical compositions comprising activated-potentiated antibodies to interferon-gamma and S100 protein |
| DE112011102356T5 (de) | 2010-07-15 | 2013-04-18 | Oleg Iliich Epshtein | Pharmazeutische Kombinationszusammensetzung und Verfahren zur Behandlung von Erkrankungen oder Zuständen, die mit dem Herz-Kreislauf-System in Verbindung stehen |
| CN103282384A (zh) | 2010-07-15 | 2013-09-04 | 奥列格·伊里奇·爱泼斯坦 | 复合药物组合物以及对泌尿生殖系统障碍进行治疗的方法 |
| KR20130102542A (ko) | 2010-07-21 | 2013-09-17 | 올레그 일리치 엡쉬테인 | 현기증, 동요병 및 증식형-혈관 이긴장증 치료용 제약학적 복합 조성물 및 치료 방법들 |
| EP2596020A2 (en) | 2010-07-21 | 2013-05-29 | Oleg Iliich Epshtein | Method of treatment of organic diseases of nervous system, psychoorganic syndrome and encephalopathy |
| GB2496801B (en) | 2010-07-21 | 2018-04-11 | Iliich Epshtein Oleg | A method of treating alzheimer's disease |
| CN103119061A (zh) | 2010-07-21 | 2013-05-22 | 奥列格·伊里奇·爱泼斯坦 | 治疗注意力不足过动症的方法 |
| ES2425315R1 (es) | 2010-07-21 | 2014-09-08 | Oleg Iliich Epshtein | Composición farmacéutica y su uso para preparar un medicamento destinado al tratamiento sintomático de una enfermedad o afección respiratoria |
| EP2595658A2 (en) | 2010-07-21 | 2013-05-29 | Oleg Iliich Epshtein | A combination pharmaceutical composition and methods of treating diabetes and metabolic disorders |
| JP2013537532A (ja) | 2010-08-06 | 2013-10-03 | イリイチ・エプシテイン オレグ | 感染性疾患を治療及び予防する組み合わせ医薬組成物及び方法 |
| RU2517084C2 (ru) | 2010-08-06 | 2014-05-27 | Олег Ильич Эпштейн | Способ и средство для ингибирования продукции или усиления элиминации белка р24 |
| RU2535034C2 (ru) | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| US20120263725A1 (en) | 2010-08-06 | 2012-10-18 | Epshtein Oleg Iiiich | Pharmaceutical composition and methods of treating and preventing the diseases caused by HIV or associated with HIV |
| RU2535033C2 (ru) | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| US20130171161A1 (en) | 2010-12-23 | 2013-07-04 | Oleg Iliich Epshtein | Method and composition for the treatment of diseases caused by or associated with hiv |
-
2011
- 2011-07-15 CN CN2011800455232A patent/CN103119061A/zh active Pending
- 2011-07-15 GB GB1302928.5A patent/GB2496343B/en not_active Expired - Fee Related
- 2011-07-15 NZ NZ606970A patent/NZ606970A/en not_active IP Right Cessation
- 2011-07-15 FR FR1156478A patent/FR2962911A1/fr not_active Withdrawn
- 2011-07-15 JP JP2013520237A patent/JP2013535444A/ja active Pending
- 2011-07-15 IT IT000632A patent/ITTO20110632A1/it unknown
- 2011-07-15 UA UAA201300114A patent/UA112755C2/uk unknown
- 2011-07-15 WO PCT/IB2011/002327 patent/WO2012010970A2/en not_active Ceased
- 2011-07-15 CA CA2805963A patent/CA2805963A1/en not_active Abandoned
- 2011-07-15 US US13/135,895 patent/US8987206B2/en not_active Expired - Fee Related
- 2011-07-15 MX MX2013000807A patent/MX2013000807A/es not_active Application Discontinuation
- 2011-07-15 EA EA201300139A patent/EA029199B1/ru not_active IP Right Cessation
- 2011-07-15 PH PH1/2013/500144A patent/PH12013500144A1/en unknown
- 2011-07-15 EP EP11775836.7A patent/EP2596019A2/en not_active Ceased
- 2011-07-15 AU AU2011281244A patent/AU2011281244A1/en not_active Abandoned
- 2011-07-15 DE DE112011102411T patent/DE112011102411T5/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EA201300139A1 (ru) | 2014-08-29 |
| ITTO20110632A1 (it) | 2012-01-22 |
| CN103119061A (zh) | 2013-05-22 |
| US8987206B2 (en) | 2015-03-24 |
| GB2496343A (en) | 2013-05-08 |
| EP2596019A2 (en) | 2013-05-29 |
| UA112755C2 (uk) | 2016-10-25 |
| WO2012010970A2 (en) | 2012-01-26 |
| NZ606970A (en) | 2015-08-28 |
| GB2496343B (en) | 2017-11-01 |
| EA029199B1 (ru) | 2018-02-28 |
| JP2013535444A (ja) | 2013-09-12 |
| DE112011102411T5 (de) | 2013-06-27 |
| US20120321672A1 (en) | 2012-12-20 |
| CA2805963A1 (en) | 2012-01-26 |
| AU2011281244A1 (en) | 2013-03-07 |
| GB201302928D0 (en) | 2013-04-03 |
| MX2013000807A (es) | 2013-10-28 |
| WO2012010970A3 (en) | 2012-04-26 |
| PH12013500144A1 (en) | 2018-03-21 |
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