FR2745290B1 - Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments - Google Patents

Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Info

Publication number
FR2745290B1
FR2745290B1 FR9602472A FR9602472A FR2745290B1 FR 2745290 B1 FR2745290 B1 FR 2745290B1 FR 9602472 A FR9602472 A FR 9602472A FR 9602472 A FR9602472 A FR 9602472A FR 2745290 B1 FR2745290 B1 FR 2745290B1
Authority
FR
France
Prior art keywords
medicaments
application
preparation process
erythromycin derivatives
novel erythromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9602472A
Other languages
English (en)
French (fr)
Other versions
FR2745290A1 (fr
Inventor
Constantin Agouridas
Jean Francois Chantot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR9602472A priority Critical patent/FR2745290B1/fr
Priority to ARP970100760A priority patent/AR005999A1/es
Priority to ZA9701659A priority patent/ZA971659B/xx
Priority to ES97907141T priority patent/ES2176698T3/es
Priority to NZ331600A priority patent/NZ331600A/xx
Priority to US09/125,959 priority patent/US6096714A/en
Priority to SK1184-98A priority patent/SK118498A3/sk
Priority to AU19298/97A priority patent/AU716204B2/en
Priority to DE69712610T priority patent/DE69712610T2/de
Priority to PL328608A priority patent/PL191736B1/pl
Priority to UA98095031A priority patent/UA58504C2/uk
Priority to KR10-1998-0706733A priority patent/KR100486053B1/ko
Priority to APAP/P/1998/001318A priority patent/AP952A/en
Priority to CNB971926255A priority patent/CN1168734C/zh
Priority to IL12562297A priority patent/IL125622A/xx
Priority to EP97907141A priority patent/EP0885234B1/fr
Priority to AT97907141T priority patent/ATE217633T1/de
Priority to US09/838,628 priority patent/USRE38520E1/en
Priority to EA199800768A priority patent/EA001376B1/ru
Priority to BRPI9707709-7A priority patent/BR9707709B1/pt
Priority to PT97907141T priority patent/PT885234E/pt
Priority to HU9902576A priority patent/HU227567B1/hu
Priority to TR1998/01713T priority patent/TR199801713T2/xx
Priority to CZ19982587A priority patent/CZ293893B6/cs
Priority to DK97907141T priority patent/DK0885234T3/da
Priority to EE9800265A priority patent/EE9800265A/xx
Priority to JP53067197A priority patent/JP4102440B2/ja
Priority to CA002247175A priority patent/CA2247175C/fr
Priority to PCT/FR1997/000351 priority patent/WO1997031929A1/fr
Publication of FR2745290A1 publication Critical patent/FR2745290A1/fr
Application granted granted Critical
Publication of FR2745290B1 publication Critical patent/FR2745290B1/fr
Priority to BG102691A priority patent/BG63207B1/bg
Priority to NO983955A priority patent/NO983955L/no
Priority to OA9800150A priority patent/OA10845A/fr
Priority to YU37098A priority patent/YU37098A/sh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR9602472A 1996-02-28 1996-02-28 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments Expired - Lifetime FR2745290B1 (fr)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FR9602472A FR2745290B1 (fr) 1996-02-28 1996-02-28 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ARP970100760A AR005999A1 (es) 1996-02-28 1997-02-25 Nuevos derivados de eritromicina, su procedimiento de preparacion, composiciones farmaceuticas y medicamentos
ZA9701659A ZA971659B (en) 1996-02-28 1997-02-26 Erythromycin derivatives, their preparation process and their use as medicaments.
PT97907141T PT885234E (pt) 1996-02-28 1997-02-27 Novos derivados da eritromicina, seu processo de preparacao e sua aplicacao como medicamentos
US09/125,959 US6096714A (en) 1996-02-28 1997-02-27 Erythromycin derivatives, method for preparing same, and use thereof as drugs
SK1184-98A SK118498A3 (en) 1996-02-28 1997-02-27 Novel erythromycin derivatives, method for preparing same, and use thereof as drugs
AU19298/97A AU716204B2 (en) 1996-02-28 1997-02-27 Novel erythromycin derivatives, method for preparing same, and use thereof as drugs
DE69712610T DE69712610T2 (de) 1996-02-28 1997-02-27 Erythramicin-derivate, ihre verfahren zur herstellung und ihre verwendung als arzneimittel
PL328608A PL191736B1 (pl) 1996-02-28 1997-02-27 Pochodna erytromycyny, zawierająca ją kompozycja farmaceutyczna oraz sposób wytwarzania pochodnej erytromycyny
UA98095031A UA58504C2 (uk) 1996-02-28 1997-02-27 Похідні еритроміцину, спосіб їх одержання та фармацевтична композиція
KR10-1998-0706733A KR100486053B1 (ko) 1996-02-28 1997-02-27 신규에리트로마이신유도체,그의제조방법및약제로서의그의용도
APAP/P/1998/001318A AP952A (en) 1996-02-28 1997-02-27 Novel erthromycin derivatives, method for preparing same, and use thereof as drugs.
CNB971926255A CN1168734C (zh) 1996-02-28 1997-02-27 新的红霉素衍生物,它们的制备方法及它们作为药物的应用
IL12562297A IL125622A (en) 1996-02-28 1997-02-27 Erythromycin derivatives, method for preparing same and pharmaceutical compositions comprising them
EP97907141A EP0885234B1 (fr) 1996-02-28 1997-02-27 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AT97907141T ATE217633T1 (de) 1996-02-28 1997-02-27 Erythramicin-derivate, ihre verfahren zur herstellung und ihre verwendung als arzneimittel
ES97907141T ES2176698T3 (es) 1996-02-28 1997-02-27 Nuevos derivados de la eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.
EA199800768A EA001376B1 (ru) 1996-02-28 1997-02-27 Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
BRPI9707709-7A BR9707709B1 (pt) 1996-02-28 1997-02-27 Derivados da eritromicina, composições farmacêuticas contendo os mesmos, e medicamentos
NZ331600A NZ331600A (en) 1996-02-28 1997-02-27 Novel erythromycin derivatives, method for preparing same, and use thereof as drugs that have antibiotic properties
HU9902576A HU227567B1 (en) 1996-02-28 1997-02-27 Erythromycin derivatives, method for preparing them, and use thereof as drugs
TR1998/01713T TR199801713T2 (xx) 1996-02-28 1997-02-27 Yeni eritromisin t�revleri, bunlar�n haz�rlanmas�na y�nelik metodlar
CZ19982587A CZ293893B6 (cs) 1996-02-28 1997-02-27 Erythromycinové derivátyŹ způsob jejich přípravy a použití a farmaceutické kompozice s jejich obsahem
DK97907141T DK0885234T3 (da) 1996-02-28 1997-02-27 Nye erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
EE9800265A EE9800265A (et) 1996-02-28 1997-02-27 Erütromütsiini derivaadid, nende valmistamismeetod ja kasutamine ravimitena
JP53067197A JP4102440B2 (ja) 1996-02-28 1997-02-27 新規なエリスロマイシン誘導体、それらの調製方法及びそれらの医薬品としての使用
CA002247175A CA2247175C (fr) 1996-02-28 1997-02-27 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
PCT/FR1997/000351 WO1997031929A1 (fr) 1996-02-28 1997-02-27 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US09/838,628 USRE38520E1 (en) 1996-02-28 1997-02-27 Erythromycin derivatives, method for preparing same, and use thereof as drugs
BG102691A BG63207B1 (bg) 1996-02-28 1998-08-12 Нови производни на еритромицин, метод за тяхното получаване и използването им като лекарствено средство
NO983955A NO983955L (no) 1996-02-28 1998-08-27 Nye erytromycinderivater, metode for fremstilling av disse og anvendelse derav som legemidler
OA9800150A OA10845A (fr) 1996-02-28 1998-08-28 Nouveaux dérivés de l'érythromycine leur procédé de préparation et leur application comme médicaments
YU37098A YU37098A (sh) 1996-02-28 1998-08-28 Novi derivati eritromicina, postupci za njihovo pripremanje i njihova primena kao medikamenata

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9602472A FR2745290B1 (fr) 1996-02-28 1996-02-28 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
FR2745290A1 FR2745290A1 (fr) 1997-08-29
FR2745290B1 true FR2745290B1 (fr) 1998-04-03

Family

ID=9489659

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9602472A Expired - Lifetime FR2745290B1 (fr) 1996-02-28 1996-02-28 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Country Status (31)

Country Link
US (1) US6096714A (OSRAM)
EP (1) EP0885234B1 (OSRAM)
JP (1) JP4102440B2 (OSRAM)
KR (1) KR100486053B1 (OSRAM)
CN (1) CN1168734C (OSRAM)
AP (1) AP952A (OSRAM)
AR (1) AR005999A1 (OSRAM)
AT (1) ATE217633T1 (OSRAM)
AU (1) AU716204B2 (OSRAM)
BG (1) BG63207B1 (OSRAM)
BR (1) BR9707709B1 (OSRAM)
CZ (1) CZ293893B6 (OSRAM)
DE (1) DE69712610T2 (OSRAM)
DK (1) DK0885234T3 (OSRAM)
EA (1) EA001376B1 (OSRAM)
EE (1) EE9800265A (OSRAM)
ES (1) ES2176698T3 (OSRAM)
FR (1) FR2745290B1 (OSRAM)
HU (1) HU227567B1 (OSRAM)
IL (1) IL125622A (OSRAM)
NO (1) NO983955L (OSRAM)
NZ (1) NZ331600A (OSRAM)
OA (1) OA10845A (OSRAM)
PL (1) PL191736B1 (OSRAM)
PT (1) PT885234E (OSRAM)
SK (1) SK118498A3 (OSRAM)
TR (1) TR199801713T2 (OSRAM)
UA (1) UA58504C2 (OSRAM)
WO (1) WO1997031929A1 (OSRAM)
YU (1) YU37098A (OSRAM)
ZA (1) ZA971659B (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021870A1 (en) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Erythromycin a 11, 12-carbamate derivatives
AU9649598A (en) * 1997-10-29 1999-05-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a, 11,12-carbamate derivatives
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
IL144178A0 (en) 1999-01-27 2002-05-23 Pfizer Prod Inc Ketolide antibiotics
OA11945A (en) * 1999-05-24 2006-04-13 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
AU6316400A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6183800A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO2001010878A1 (fr) * 1999-08-06 2001-02-15 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
ITMI20021726A1 (it) 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2005007143A2 (en) * 2003-07-14 2005-01-27 The Board Of Trustees Of The University Of Illinois Use of makrolides and ketolides for the treatment of tuberculosis
WO2007069264A2 (en) * 2005-12-15 2007-06-21 Alembic Limited Reference standards for determining the purity of telithromycin and processes therefor
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP2358379B1 (en) * 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
KR101945324B1 (ko) 2010-05-20 2019-02-07 셈프라 파마슈티컬스, 인크. 매크로라이드들 및 케톨라이드들과 이의 중간체들을 제조하는 공정들
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487411A (en) * 1892-12-06 Island
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5444031A (en) * 1993-01-21 1995-08-22 Calgon Carbon Corporation Process for making catalytic carbon
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
ATE217633T1 (de) 2002-06-15
JP4102440B2 (ja) 2008-06-18
PL328608A1 (en) 1999-02-01
DK0885234T3 (da) 2002-08-26
AR005999A1 (es) 1999-07-21
OA10845A (fr) 2003-02-05
CN1212700A (zh) 1999-03-31
DE69712610D1 (de) 2002-06-20
PL191736B1 (pl) 2006-06-30
BG63207B1 (bg) 2001-06-29
SK118498A3 (en) 1999-07-12
CZ293893B6 (cs) 2004-08-18
EA199800768A1 (ru) 1999-02-25
HUP9902576A3 (en) 2001-03-28
YU37098A (sh) 1999-07-28
AP952A (en) 2001-03-29
NZ331600A (en) 1999-08-30
ES2176698T3 (es) 2002-12-01
AP9801318A0 (en) 1998-09-30
UA58504C2 (uk) 2003-08-15
JP2000505469A (ja) 2000-05-09
PT885234E (pt) 2002-10-31
WO1997031929A1 (fr) 1997-09-04
BG102691A (en) 1999-06-30
NO983955D0 (no) 1998-08-27
HU227567B1 (en) 2011-08-29
EA001376B1 (ru) 2001-02-26
FR2745290A1 (fr) 1997-08-29
TR199801713T2 (xx) 1998-12-21
BR9707709B1 (pt) 2014-10-14
KR100486053B1 (ko) 2005-06-16
EE9800265A (et) 1999-02-15
US6096714A (en) 2000-08-01
CZ258798A3 (cs) 1998-12-16
ZA971659B (en) 1998-02-26
NO983955L (no) 1998-08-27
DE69712610T2 (de) 2002-11-28
EP0885234A1 (fr) 1998-12-23
AU1929897A (en) 1997-09-16
HUP9902576A1 (hu) 1999-12-28
EP0885234B1 (fr) 2002-05-15
CN1168734C (zh) 2004-09-29
BR9707709A (pt) 1999-04-06
AU716204B2 (en) 2000-02-24
IL125622A (en) 2003-10-31
IL125622A0 (en) 1999-04-11
KR19990087324A (ko) 1999-12-27

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