FR2695126B1 - Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant. - Google Patents

Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Info

Publication number
FR2695126B1
FR2695126B1 FR9210329A FR9210329A FR2695126B1 FR 2695126 B1 FR2695126 B1 FR 2695126B1 FR 9210329 A FR9210329 A FR 9210329A FR 9210329 A FR9210329 A FR 9210329A FR 2695126 B1 FR2695126 B1 FR 2695126B1
Authority
FR
France
Prior art keywords
thienyl
alkyl
nz1z2
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9210329A
Other languages
English (en)
French (fr)
Other versions
FR2695126A1 (fr
Inventor
Andre Bachy
Laurent Fraisse
Peter Keane
Etienne Mendes
Jean-Claude Vernieres
Jacques Simiand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elf Sanofi SA
Original Assignee
Elf Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elf Sanofi SA filed Critical Elf Sanofi SA
Priority to FR9210329A priority Critical patent/FR2695126B1/fr
Priority to US08/109,073 priority patent/US5360799A/en
Priority to AU44747/93A priority patent/AU659027B2/en
Priority to AT93402095T priority patent/ATE173258T1/de
Priority to DK93402095T priority patent/DK0587473T3/da
Priority to DE69322033T priority patent/DE69322033T2/de
Priority to NZ248498A priority patent/NZ248498A/en
Priority to ES93402095T priority patent/ES2125315T3/es
Priority to EP93402095A priority patent/EP0587473B1/fr
Priority to NO933051A priority patent/NO300845B1/no
Priority to FI933756A priority patent/FI103889B/fi
Priority to MX9305181A priority patent/MX9305181A/es
Priority to CA002104883A priority patent/CA2104883A1/fr
Priority to HU9302425A priority patent/HU217623B/hu
Priority to JP5211451A priority patent/JPH06184145A/ja
Priority to KR1019930017022A priority patent/KR100267802B1/ko
Publication of FR2695126A1 publication Critical patent/FR2695126A1/fr
Priority to US08/273,943 priority patent/US5468750A/en
Application granted granted Critical
Publication of FR2695126B1 publication Critical patent/FR2695126B1/fr
Priority to FI962714A priority patent/FI103277B/fi
Priority to GR990400363T priority patent/GR3029283T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Toys (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
FR9210329A 1992-08-27 1992-08-27 Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant. Expired - Fee Related FR2695126B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR9210329A FR2695126B1 (fr) 1992-08-27 1992-08-27 Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
US08/109,073 US5360799A (en) 1992-08-27 1993-08-19 Substituted thienyl- or pyrrolylcarboxyclic acid derivatives, their preparation and medicines containing them
AU44747/93A AU659027B2 (en) 1992-08-27 1993-08-20 Substituted thienyl- or pyrrolylcarboxyclic acid derivatives, their preparation and medicines containing them
DK93402095T DK0587473T3 (da) 1992-08-27 1993-08-25 Kondenserede pyridinderivater som inhibitorer af virkningerne af frie radikaler
DE69322033T DE69322033T2 (de) 1992-08-27 1993-08-25 Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler
NZ248498A NZ248498A (en) 1992-08-27 1993-08-25 Pyrrolo(or thieno)[3,2-c]quinoline carboxylates and naphthyridine analogues; pharmaceutical compositions
ES93402095T ES2125315T3 (es) 1992-08-27 1993-08-25 Derivados condensados de la piridina como inhibidores del efecto de los radicales libres.
EP93402095A EP0587473B1 (fr) 1992-08-27 1993-08-25 Dérivés condensés de la pyridine comme inhibiteurs de l'effet des radicaux libres
AT93402095T ATE173258T1 (de) 1992-08-27 1993-08-25 Kondensierte pyridin derivate als hemmer von effekten freier radikaler
MX9305181A MX9305181A (es) 1992-08-27 1993-08-26 Derivados de los acidos y tienilo o pirrolil carboxilicos procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
NO933051A NO300845B1 (no) 1992-08-27 1993-08-26 Substituerte tienyl- eller pyrrolylkarboksylsyrederivater, og medisiner som inneholder dem
CA002104883A CA2104883A1 (fr) 1992-08-27 1993-08-26 Derives d'acide thienyl ou pyrrolyl carboxyliques, leur preparation et medicaments les contenant
HU9302425A HU217623B (hu) 1992-08-27 1993-08-26 Eljárás kondenzált tieno- és pirrolo [3,2-c]piridin-2-karbonsav-származékok valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására
JP5211451A JPH06184145A (ja) 1992-08-27 1993-08-26 チエニル−またはピロリル−カルボン酸誘導体、製法および医薬組成物
FI933756A FI103889B (fi) 1992-08-27 1993-08-26 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo£3,2-c|-kinoliini-karboksyylihappojohdannaisten valmistamiseksi
KR1019930017022A KR100267802B1 (ko) 1992-08-27 1993-08-27 치환된티에닐-또는피롤일카르복시산유도체,그의제조방법및그를함유하는약제학적조성물
US08/273,943 US5468750A (en) 1992-08-27 1994-07-12 Heterocycle-coupled substituted pyrrolo[3,2-c]pyridin-2-carboxylic acids
FI962714A FI103277B (fi) 1992-08-27 1996-07-01 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja tieno£3,2-c|naf tyridiinijohdannaisten valmistamiseksi
GR990400363T GR3029283T3 (en) 1992-08-27 1999-02-03 Method of preparing a radioactive rhenium complex solution.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9210329A FR2695126B1 (fr) 1992-08-27 1992-08-27 Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Publications (2)

Publication Number Publication Date
FR2695126A1 FR2695126A1 (fr) 1994-03-04
FR2695126B1 true FR2695126B1 (fr) 1994-11-10

Family

ID=9433050

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9210329A Expired - Fee Related FR2695126B1 (fr) 1992-08-27 1992-08-27 Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Country Status (17)

Country Link
US (2) US5360799A (no)
EP (1) EP0587473B1 (no)
JP (1) JPH06184145A (no)
KR (1) KR100267802B1 (no)
AT (1) ATE173258T1 (no)
AU (1) AU659027B2 (no)
CA (1) CA2104883A1 (no)
DE (1) DE69322033T2 (no)
DK (1) DK0587473T3 (no)
ES (1) ES2125315T3 (no)
FI (1) FI103889B (no)
FR (1) FR2695126B1 (no)
GR (1) GR3029283T3 (no)
HU (1) HU217623B (no)
MX (1) MX9305181A (no)
NO (1) NO300845B1 (no)
NZ (1) NZ248498A (no)

Families Citing this family (33)

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AU2003256650A1 (en) * 2002-07-19 2004-02-09 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
CN103214483B (zh) 2005-12-13 2014-12-17 因塞特公司 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2，3-b]吡啶和吡咯并[2，3-b]嘧啶
CN101679357A (zh) * 2007-05-09 2010-03-24 辉瑞大药厂 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
WO2008154447A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazolonaphthyridine derivatives
WO2009027393A2 (en) 2007-08-27 2009-03-05 Basf Se Pyrazole compounds for controlling invertebrate pests
JP4719317B2 (ja) * 2008-02-26 2011-07-06 武田薬品工業株式会社 縮合複素環誘導体およびその用途
AU2009295936B2 (en) 2008-09-24 2014-07-17 Basf Se Pyrazole compounds for controlling invertebrate pests
BRPI1012159B1 (pt) 2009-05-22 2022-01-25 Incyte Holdings Corporation Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos
DK2432472T3 (da) 2009-05-22 2019-11-18 Incyte Holdings Corp 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer
EP2451804B1 (en) 2009-07-06 2014-04-30 Basf Se Pyridazine compounds for controlling invertebrate pests
WO2011009804A2 (en) 2009-07-24 2011-01-27 Basf Se Pyridine derivatives compounds for controlling invertebrate pests
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
KR102283091B1 (ko) 2010-03-10 2021-07-30 인사이트 홀딩스 코포레이션 Ｊａｋ１ 저해제로서의 피페리딘­４­일 아제티딘 유도체
AR083933A1 (es) 2010-11-19 2013-04-10 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
CN103797010B (zh) 2011-06-20 2016-02-24 因塞特控股公司 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
SG10201703533VA (en) 2012-11-01 2017-06-29 Incyte Corp Tricyclic fused thiophene derivatives as jak inhibitors
CR20190073A (es) 2012-11-15 2019-04-25 Incyte Holdings Corp FORMAS DE DOSIFICACIÓN DE RUXOLITINIB DE LIBERACIÓN SOTENIDA (Divisional 2015-265)
RS62867B1 (sr) 2013-03-06 2022-02-28 Incyte Holdings Corp Postupci i intermedijeri za dobijanje inhibitora jak
EP3030227B1 (en) 2013-08-07 2020-04-08 Incyte Corporation Sustained release dosage forms for a jak1 inhibitor
CA2947418A1 (en) 2014-04-30 2015-11-05 Incyte Corporation Processes of preparing a jak1 inhibitor and new forms thereto
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
JP2018537450A (ja) 2015-11-16 2018-12-20 ファンダシオン パラ ラ インベスティガシオン メディカ アプリカダＦｕｎｄａｃｉｏｎ Ｐａｒａ Ｌａ Ｉｎｖｅｓｔｉｇａｓｉｏｎ Ｍｅｄｉｃａ Ａｐｌｉｃａｄａ Ｄｎａメチルトランスフェラーゼ阻害剤としての新規化合物
JP2021519775A (ja) 2018-03-30 2021-08-12 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
AU2022367432A1 (en) 2021-10-14 2024-05-02 Incyte Corporation Quinoline compounds as inhibitors of kras
US11897883B1 (en) 2023-09-01 2024-02-13 King Faisal University Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11891377B1 (en) 2023-09-06 2024-02-06 King Faisal University Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11866437B1 (en) 2023-09-15 2024-01-09 King Faisal University 1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors
US11952378B1 (en) 2023-12-14 2024-04-09 King Faisal University Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors

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US3887570A (en) * 1973-09-28 1975-06-03 Squibb & Sons Inc Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids

Also Published As

Publication number Publication date
NO933051L (no) 1994-02-28
JPH06184145A (ja) 1994-07-05
US5360799A (en) 1994-11-01
GR3029283T3 (en) 1999-05-28
FR2695126A1 (fr) 1994-03-04
DE69322033D1 (de) 1998-12-17
NO933051D0 (no) 1993-08-26
KR100267802B1 (ko) 2000-11-01
CA2104883A1 (fr) 1994-02-28
KR940003958A (ko) 1994-03-14
HUT64957A (en) 1994-03-28
FI933756A0 (fi) 1993-08-26
US5468750A (en) 1995-11-21
EP0587473B1 (fr) 1998-11-11
HU9302425D0 (en) 1993-11-29
FI933756A (fi) 1994-02-28
NZ248498A (en) 1994-09-27
AU659027B2 (en) 1995-05-04
AU4474793A (en) 1994-03-03
DE69322033T2 (de) 1999-06-17
MX9305181A (es) 1994-06-30
FI103889B1 (fi) 1999-10-15
FI103889B (fi) 1999-10-15
EP0587473A1 (fr) 1994-03-16
DK0587473T3 (da) 1999-07-26
ATE173258T1 (de) 1998-11-15
HU217623B (hu) 2000-03-28
NO300845B1 (no) 1997-08-04
ES2125315T3 (es) 1999-03-01

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