DE69322033D1 - Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler - Google Patents

Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler

Info

Publication number
DE69322033D1
DE69322033D1 DE69322033T DE69322033T DE69322033D1 DE 69322033 D1 DE69322033 D1 DE 69322033D1 DE 69322033 T DE69322033 T DE 69322033T DE 69322033 T DE69322033 T DE 69322033T DE 69322033 D1 DE69322033 D1 DE 69322033D1
Authority
DE
Germany
Prior art keywords
alkyl
nz1z2
alkoxy
phenyl
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69322033T
Other languages
English (en)
Other versions
DE69322033T2 (de
Inventor
Andre Bachy
Laurent Fraisse
Peter Keane
Etienne Mendes
Jean-Claude Vernieres
Jacques Simiand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69322033D1 publication Critical patent/DE69322033D1/de
Application granted granted Critical
Publication of DE69322033T2 publication Critical patent/DE69322033T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Toys (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DE69322033T 1992-08-27 1993-08-25 Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler Expired - Fee Related DE69322033T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9210329A FR2695126B1 (fr) 1992-08-27 1992-08-27 Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Publications (2)

Publication Number Publication Date
DE69322033D1 true DE69322033D1 (de) 1998-12-17
DE69322033T2 DE69322033T2 (de) 1999-06-17

Family

ID=9433050

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69322033T Expired - Fee Related DE69322033T2 (de) 1992-08-27 1993-08-25 Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler

Country Status (17)

Country Link
US (2) US5360799A (de)
EP (1) EP0587473B1 (de)
JP (1) JPH06184145A (de)
KR (1) KR100267802B1 (de)
AT (1) ATE173258T1 (de)
AU (1) AU659027B2 (de)
CA (1) CA2104883A1 (de)
DE (1) DE69322033T2 (de)
DK (1) DK0587473T3 (de)
ES (1) ES2125315T3 (de)
FI (1) FI103889B1 (de)
FR (1) FR2695126B1 (de)
GR (1) GR3029283T3 (de)
HU (1) HU217623B (de)
MX (1) MX9305181A (de)
NO (1) NO300845B1 (de)
NZ (1) NZ248498A (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009582A1 (en) * 2002-07-19 2004-01-29 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
HUE030235T2 (en) 2005-12-13 2017-04-28 Incyte Holdings Corp Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors
EP2481735A1 (de) * 2007-05-09 2012-08-01 Pfizer Inc. Substituierte heterocyclische Derivate und Zusammensetzungen und ihre pharmazeutische Verwendung als antibakterielle Mittel
CN101754681A (zh) * 2007-06-08 2010-06-23 海利空医疗公司 治疗用吡唑并萘啶衍生物
PL2197280T3 (pl) 2007-08-27 2013-11-29 Basf Se Związki pirazolowe do zwalczania szkodników będących bezkręgowcami
MX2010009372A (es) * 2008-02-26 2010-09-22 Takeda Pharmaceutical Derivado heterociclico fusionado y su uso.
US8729083B2 (en) 2008-09-24 2014-05-20 Basf Se Pyrazole compounds for controlling invertebrate pests
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
EA020494B1 (ru) 2009-05-22 2014-11-28 Инсайт Корпорейшн 3-[4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ]ОКТАН- ИЛИ ГЕПТАННИТРИЛ КАК JAK-ИНГИБИТОРЫ
WO2011003796A1 (en) 2009-07-06 2011-01-13 Basf Se Pyridazine compounds for controlling invertebrate pests
EP2456308A2 (de) 2009-07-24 2012-05-30 Basf Se Pyridinderivate zur bekämpfung von wirbellosen schädlingen
AR078012A1 (es) 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
MX347851B (es) 2010-03-10 2017-05-16 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
SG190839A1 (en) 2010-11-19 2013-07-31 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
AR086983A1 (es) 2011-06-20 2014-02-05 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
AR091079A1 (es) 2012-05-18 2014-12-30 Incyte Corp Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
NZ707495A (en) 2012-11-01 2019-01-25 Incyte Holdings Corp Tricyclic fused thiophene derivatives as jak inhibitors
KR20220162825A (ko) 2012-11-15 2022-12-08 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
AU2014225938B2 (en) 2013-03-06 2018-07-19 Incyte Holdings Corporation Processes and intermediates for making a JAK inhibitor
KR20160045081A (ko) 2013-08-07 2016-04-26 인사이트 코포레이션 Jak1 억제제용 지속 방출 복용 형태
TW201625643A (zh) 2014-04-30 2016-07-16 英塞特公司 製備ｊａｋ１抑制劑之方法及其新形式
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
EP3377490A1 (de) 2015-11-16 2018-09-26 Fundacion para la Investigacion Medica Aplicada Neuartige verbindungen als inhibitoren von dna-methyltransferasen
MX2022012285A (es) 2018-03-30 2023-08-15 Incyte Corp Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
US11939328B2 (en) 2021-10-14 2024-03-26 Incyte Corporation Quinoline compounds as inhibitors of KRAS
US11897883B1 (en) 2023-09-01 2024-02-13 King Faisal University Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11891377B1 (en) 2023-09-06 2024-02-06 King Faisal University Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11866437B1 (en) 2023-09-15 2024-01-09 King Faisal University 1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors
US11952378B1 (en) 2023-12-14 2024-04-09 King Faisal University Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887570A (en) * 1973-09-28 1975-06-03 Squibb & Sons Inc Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids

Also Published As

Publication number Publication date
HU217623B (hu) 2000-03-28
FR2695126A1 (fr) 1994-03-04
US5468750A (en) 1995-11-21
ES2125315T3 (es) 1999-03-01
AU659027B2 (en) 1995-05-04
FI933756A0 (fi) 1993-08-26
EP0587473A1 (de) 1994-03-16
HUT64957A (en) 1994-03-28
KR100267802B1 (ko) 2000-11-01
HU9302425D0 (en) 1993-11-29
KR940003958A (ko) 1994-03-14
NO300845B1 (no) 1997-08-04
NO933051L (no) 1994-02-28
JPH06184145A (ja) 1994-07-05
CA2104883A1 (fr) 1994-02-28
NO933051D0 (no) 1993-08-26
DK0587473T3 (da) 1999-07-26
NZ248498A (en) 1994-09-27
FI103889B (fi) 1999-10-15
ATE173258T1 (de) 1998-11-15
EP0587473B1 (de) 1998-11-11
FI103889B1 (fi) 1999-10-15
MX9305181A (es) 1994-06-30
FR2695126B1 (fr) 1994-11-10
US5360799A (en) 1994-11-01
FI933756A (fi) 1994-02-28
AU4474793A (en) 1994-03-03
DE69322033T2 (de) 1999-06-17
GR3029283T3 (en) 1999-05-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8339 Ceased/non-payment of the annual fee