ATE173258T1 - Kondensierte pyridin derivate als hemmer von effekten freier radikaler - Google Patents
Kondensierte pyridin derivate als hemmer von effekten freier radikalerInfo
- Publication number
- ATE173258T1 ATE173258T1 AT93402095T AT93402095T ATE173258T1 AT E173258 T1 ATE173258 T1 AT E173258T1 AT 93402095 T AT93402095 T AT 93402095T AT 93402095 T AT93402095 T AT 93402095T AT E173258 T1 ATE173258 T1 AT E173258T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- nz1z2
- alkoxy
- phenyl
- inhibiters
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 150000003254 radicals Chemical class 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- -1 benzyloxy, benzyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrrole Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Toys (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9210329A FR2695126B1 (fr) | 1992-08-27 | 1992-08-27 | Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE173258T1 true ATE173258T1 (de) | 1998-11-15 |
Family
ID=9433050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93402095T ATE173258T1 (de) | 1992-08-27 | 1993-08-25 | Kondensierte pyridin derivate als hemmer von effekten freier radikaler |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5360799A (de) |
| EP (1) | EP0587473B1 (de) |
| JP (1) | JPH06184145A (de) |
| KR (1) | KR100267802B1 (de) |
| AT (1) | ATE173258T1 (de) |
| AU (1) | AU659027B2 (de) |
| CA (1) | CA2104883A1 (de) |
| DE (1) | DE69322033T2 (de) |
| DK (1) | DK0587473T3 (de) |
| ES (1) | ES2125315T3 (de) |
| FI (1) | FI103889B (de) |
| FR (1) | FR2695126B1 (de) |
| GR (1) | GR3029283T3 (de) |
| HU (1) | HU217623B (de) |
| MX (1) | MX9305181A (de) |
| NO (1) | NO300845B1 (de) |
| NZ (1) | NZ248498A (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003256650A1 (en) * | 2002-07-19 | 2004-02-09 | Pharmacia Corporation | Substituted thiophene carboxamide compounds for the treatment of inflammation |
| GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
| HUE028588T2 (hu) | 2005-12-13 | 2016-12-28 | Incyte Holdings Corp | Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok |
| EP2481735A1 (de) * | 2007-05-09 | 2012-08-01 | Pfizer Inc. | Substituierte heterocyclische Derivate und Zusammensetzungen und ihre pharmazeutische Verwendung als antibakterielle Mittel |
| KR20100036306A (ko) * | 2007-06-08 | 2010-04-07 | 헬리콘 테라퓨틱스 인코퍼레이티드 | 치료용 피라졸로나프티리딘 유도체 |
| ES2423932T3 (es) | 2007-08-27 | 2013-09-25 | Basf Se | Compuestos de pirazol para controlar plagas de invertebrados |
| CN102015705B (zh) * | 2008-02-26 | 2013-11-13 | 武田药品工业株式会社 | 稠合的杂环衍生物及其用途 |
| TWI607996B (zh) | 2008-09-24 | 2017-12-11 | 巴地斯顏料化工廠 | 控制無脊椎害蟲之吡唑化合物 |
| BRPI1012108B8 (pt) | 2009-05-22 | 2021-05-25 | Incyte Corp | composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico |
| NZ596479A (en) | 2009-05-22 | 2014-01-31 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| ES2472918T3 (es) | 2009-07-06 | 2014-07-03 | Basf Se | Compuestos de piridazina para controlar plagas de invertebrados |
| JP2013500246A (ja) | 2009-07-24 | 2013-01-07 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物系害虫防除用ピリジン誘導体化合物 |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CA2792508C (en) | 2010-03-10 | 2018-01-16 | Incyte Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| CA2888816A1 (en) | 2012-11-01 | 2014-05-08 | Incyte Corporation | Tricyclic fused thiophene derivatives as jak inhibitors |
| KR102242077B1 (ko) | 2012-11-15 | 2021-04-20 | 인사이트 홀딩스 코포레이션 | 룩솔리티니브의 서방성 제형 |
| EP3489239B1 (de) | 2013-03-06 | 2021-09-15 | Incyte Holdings Corporation | Verfahren und zwischenprodukte zur herstellung eines jak-hemmers |
| MX376856B (es) | 2013-08-07 | 2025-03-07 | Incyte Holdings Corp | Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1). |
| SG11201609016VA (en) | 2014-04-30 | 2016-11-29 | Incyte Corp | Processes of preparing a jak1 inhibitor and new forms thereto |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| US10407423B2 (en) | 2015-11-16 | 2019-09-10 | Fundación Para La Investigación Médica Aplicada | Compounds as inhibitors of DNA methyltransferases |
| KR20260080448A (ko) | 2018-03-30 | 2026-06-02 | 인사이트 코포레이션 | Jak 억제제를 사용하는 화농성 한선염의 치료 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
| US11897883B1 (en) | 2023-09-01 | 2024-02-13 | King Faisal University | Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors |
| US11891377B1 (en) | 2023-09-06 | 2024-02-06 | King Faisal University | Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors |
| US11866437B1 (en) | 2023-09-15 | 2024-01-09 | King Faisal University | 1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors |
| US11952378B1 (en) | 2023-12-14 | 2024-04-09 | King Faisal University | Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors |
| WO2026076207A1 (en) * | 2024-10-04 | 2026-04-09 | Incyte Corporation | Tricyclic heteroaryl compounds as inhibitors of tyk2 and/or jak1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887570A (en) * | 1973-09-28 | 1975-06-03 | Squibb & Sons Inc | Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids |
-
1992
- 1992-08-27 FR FR9210329A patent/FR2695126B1/fr not_active Expired - Fee Related
-
1993
- 1993-08-19 US US08/109,073 patent/US5360799A/en not_active Expired - Fee Related
- 1993-08-20 AU AU44747/93A patent/AU659027B2/en not_active Ceased
- 1993-08-25 NZ NZ248498A patent/NZ248498A/en unknown
- 1993-08-25 ES ES93402095T patent/ES2125315T3/es not_active Expired - Lifetime
- 1993-08-25 AT AT93402095T patent/ATE173258T1/de not_active IP Right Cessation
- 1993-08-25 EP EP93402095A patent/EP0587473B1/de not_active Expired - Lifetime
- 1993-08-25 DK DK93402095T patent/DK0587473T3/da active
- 1993-08-25 DE DE69322033T patent/DE69322033T2/de not_active Expired - Fee Related
- 1993-08-26 JP JP5211451A patent/JPH06184145A/ja active Pending
- 1993-08-26 FI FI933756A patent/FI103889B/fi active
- 1993-08-26 HU HU9302425A patent/HU217623B/hu not_active IP Right Cessation
- 1993-08-26 NO NO933051A patent/NO300845B1/no not_active IP Right Cessation
- 1993-08-26 MX MX9305181A patent/MX9305181A/es not_active IP Right Cessation
- 1993-08-26 CA CA002104883A patent/CA2104883A1/fr not_active Abandoned
- 1993-08-27 KR KR1019930017022A patent/KR100267802B1/ko not_active Expired - Fee Related
-
1994
- 1994-07-12 US US08/273,943 patent/US5468750A/en not_active Expired - Fee Related
-
1999
- 1999-02-03 GR GR990400363T patent/GR3029283T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0587473A1 (de) | 1994-03-16 |
| KR100267802B1 (ko) | 2000-11-01 |
| GR3029283T3 (en) | 1999-05-28 |
| EP0587473B1 (de) | 1998-11-11 |
| NO933051L (no) | 1994-02-28 |
| FI933756A0 (fi) | 1993-08-26 |
| DE69322033D1 (de) | 1998-12-17 |
| DE69322033T2 (de) | 1999-06-17 |
| AU659027B2 (en) | 1995-05-04 |
| NO933051D0 (no) | 1993-08-26 |
| FR2695126B1 (fr) | 1994-11-10 |
| ES2125315T3 (es) | 1999-03-01 |
| NZ248498A (en) | 1994-09-27 |
| DK0587473T3 (da) | 1999-07-26 |
| NO300845B1 (no) | 1997-08-04 |
| US5360799A (en) | 1994-11-01 |
| AU4474793A (en) | 1994-03-03 |
| JPH06184145A (ja) | 1994-07-05 |
| FI933756L (fi) | 1994-02-28 |
| MX9305181A (es) | 1994-06-30 |
| HU217623B (hu) | 2000-03-28 |
| HUT64957A (en) | 1994-03-28 |
| HU9302425D0 (en) | 1993-11-29 |
| US5468750A (en) | 1995-11-21 |
| FI103889B1 (fi) | 1999-10-15 |
| CA2104883A1 (fr) | 1994-02-28 |
| FI103889B (fi) | 1999-10-15 |
| FR2695126A1 (fr) | 1994-03-04 |
| KR940003958A (ko) | 1994-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |