DE69322033T2 - Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler - Google Patents

Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler

Info

Publication number
DE69322033T2
DE69322033T2 DE69322033T DE69322033T DE69322033T2 DE 69322033 T2 DE69322033 T2 DE 69322033T2 DE 69322033 T DE69322033 T DE 69322033T DE 69322033 T DE69322033 T DE 69322033T DE 69322033 T2 DE69322033 T2 DE 69322033T2
Authority
DE
Germany
Prior art keywords
alkyl
nz1z2
alkoxy
phenyl
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69322033T
Other languages
English (en)
Other versions
DE69322033D1 (de
Inventor
Andre Bachy
Laurent Fraisse
Peter Keane
Etienne Mendes
Jean-Claude Vernieres
Jacques Simiand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69322033D1 publication Critical patent/DE69322033D1/de
Application granted granted Critical
Publication of DE69322033T2 publication Critical patent/DE69322033T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Toys (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69322033T 1992-08-27 1993-08-25 Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler Expired - Fee Related DE69322033T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9210329A FR2695126B1 (fr) 1992-08-27 1992-08-27 Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Publications (2)

Publication Number Publication Date
DE69322033D1 DE69322033D1 (de) 1998-12-17
DE69322033T2 true DE69322033T2 (de) 1999-06-17

Family

ID=9433050

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69322033T Expired - Fee Related DE69322033T2 (de) 1992-08-27 1993-08-25 Kondensierte Pyridin Derivate als Hemmer von Effekten freier Radikaler

Country Status (17)

Country Link
US (2) US5360799A (de)
EP (1) EP0587473B1 (de)
JP (1) JPH06184145A (de)
KR (1) KR100267802B1 (de)
AT (1) ATE173258T1 (de)
AU (1) AU659027B2 (de)
CA (1) CA2104883A1 (de)
DE (1) DE69322033T2 (de)
DK (1) DK0587473T3 (de)
ES (1) ES2125315T3 (de)
FI (1) FI103889B (de)
FR (1) FR2695126B1 (de)
GR (1) GR3029283T3 (de)
HU (1) HU217623B (de)
MX (1) MX9305181A (de)
NO (1) NO300845B1 (de)
NZ (1) NZ248498A (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009582A1 (en) * 2002-07-19 2004-01-29 Pharmacia Corporation Substituted thiophene carboxamide compounds for the treatment of inflammation
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
LT2474545T (lt) 2005-12-13 2017-02-27 Incyte Holdings Corporation Heteroarilu pakeisti pirolo[2,3-b]piridinai ir pirolo[2,3-b]pirimidinai kaip janus kinazės inhibitoriai
AU2008249745B2 (en) * 2007-05-09 2012-01-12 Pfizer Inc. Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials
CN101754681A (zh) * 2007-06-08 2010-06-23 海利空医疗公司 治疗用吡唑并萘啶衍生物
EP2197280B1 (de) 2007-08-27 2013-06-19 Basf Se Pyrazolverbindungen für die bekämpfung von wirbellosen schädlingen
CN102015705B (zh) * 2008-02-26 2013-11-13 武田药品工业株式会社 稠合的杂环衍生物及其用途
JP5536073B2 (ja) 2008-09-24 2014-07-02 ビーエーエスエフ ソシエタス・ヨーロピア 無脊椎動物系害虫を防除するためのピラゾール化合物
JP5775070B2 (ja) 2009-05-22 2015-09-09 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ヤヌスキナーゼ阻害剤としてのピラゾール−４−イル−ピロロ［２，３−ｄ］ピリミジンおよびピロール−３−イル−ピロロ［２，３−ｄ］ピリミジンのＮ−（ヘテロ）アリール−ピロリジン誘導体
MY161416A (en) 2009-05-22 2017-04-14 Incyte Holdings Corp 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4yl)-1h-pyrazol-1-yl]octane-or heptane-nitrile as jak inhibitors
EP2451804B1 (de) 2009-07-06 2014-04-30 Basf Se Pyridazinverbindungen zur bekämpfung von wirbellosen schädlingen
JP2013500246A (ja) 2009-07-24 2013-01-07 ビーエーエスエフ ソシエタス・ヨーロピア 無脊椎動物系害虫防除用ピリジン誘導体化合物
US9249145B2 (en) 2009-09-01 2016-02-02 Incyte Holdings Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
AR081315A1 (es) 2010-03-10 2012-08-08 Incyte Corp Derivados heterociclicos de piperidin y pirimidin -4-il-azetidina, una forma cristalina de la sal del acido acetonitriladipico de un derivado pirimidinico, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades relacionadas con la inhibicion de jak-1, t
AR083933A1 (es) 2010-11-19 2013-04-10 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
PE20140832A1 (es) 2011-06-20 2014-07-14 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
SG11201503141TA (en) 2012-11-01 2015-06-29 Incyte Corp Tricyclic fused thiophene derivatives as jak inhibitors
CA3178452A1 (en) 2012-11-15 2014-05-22 Incyte Holdings Corporation Sustained-release dosage forms of ruxolitinib
LT3489239T (lt) 2013-03-06 2022-03-10 Incyte Holdings Corporation Jak inhibitoriaus gamybos būdai ir tarpiniai junginiai
MY195091A (en) 2013-08-07 2023-01-10 Incyte Corp Sustained Release Dosage Forms for a JAK1 Inhibitor
CN106687462A (zh) 2014-04-30 2017-05-17 因赛特公司 Jak1抑制剂的制备方法以及其新形式
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
EP3377490A1 (de) 2015-11-16 2018-09-26 Fundacion para la Investigacion Medica Aplicada Neuartige verbindungen als inhibitoren von dna-methyltransferasen
MX2020010322A (es) 2018-03-30 2022-11-30 Incyte Corp Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
US11939328B2 (en) 2021-10-14 2024-03-26 Incyte Corporation Quinoline compounds as inhibitors of KRAS
US11897883B1 (en) 2023-09-01 2024-02-13 King Faisal University Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11891377B1 (en) 2023-09-06 2024-02-06 King Faisal University Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11866437B1 (en) 2023-09-15 2024-01-09 King Faisal University 1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors
US11952378B1 (en) 2023-12-14 2024-04-09 King Faisal University Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887570A (en) * 1973-09-28 1975-06-03 Squibb & Sons Inc Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids

Also Published As

Publication number Publication date
FI103889B1 (fi) 1999-10-15
KR940003958A (ko) 1994-03-14
HU9302425D0 (en) 1993-11-29
NO933051L (no) 1994-02-28
NZ248498A (en) 1994-09-27
EP0587473B1 (de) 1998-11-11
HU217623B (hu) 2000-03-28
DE69322033D1 (de) 1998-12-17
DK0587473T3 (da) 1999-07-26
ES2125315T3 (es) 1999-03-01
US5360799A (en) 1994-11-01
KR100267802B1 (ko) 2000-11-01
EP0587473A1 (de) 1994-03-16
FR2695126A1 (fr) 1994-03-04
FI103889B (fi) 1999-10-15
CA2104883A1 (fr) 1994-02-28
GR3029283T3 (en) 1999-05-28
NO300845B1 (no) 1997-08-04
HUT64957A (en) 1994-03-28
AU4474793A (en) 1994-03-03
FI933756A (fi) 1994-02-28
MX9305181A (es) 1994-06-30
AU659027B2 (en) 1995-05-04
NO933051D0 (no) 1993-08-26
JPH06184145A (ja) 1994-07-05
FR2695126B1 (fr) 1994-11-10
ATE173258T1 (de) 1998-11-15
FI933756A0 (fi) 1993-08-26
US5468750A (en) 1995-11-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8339 Ceased/non-payment of the annual fee