FR2629819B1 - Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii - Google Patents

Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Info

Publication number
FR2629819B1
FR2629819B1 FR8804513A FR8804513A FR2629819B1 FR 2629819 B1 FR2629819 B1 FR 2629819B1 FR 8804513 A FR8804513 A FR 8804513A FR 8804513 A FR8804513 A FR 8804513A FR 2629819 B1 FR2629819 B1 FR 2629819B1
Authority
FR
France
Prior art keywords
baccatin iii
iii
desacetyl
preparation
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8804513A
Other languages
English (en)
French (fr)
Other versions
FR2629819A1 (fr
Inventor
Michel Colin
Daniel Guenard
Francoise Gueritte-Voegelein
Pierre Potier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Priority to FR8804513A priority Critical patent/FR2629819B1/fr
Priority to US07/331,758 priority patent/US4924012A/en
Priority to IL89831A priority patent/IL89831A/xx
Priority to AU32426/89A priority patent/AU618333B2/en
Priority to ZA892474A priority patent/ZA892474B/xx
Priority to JP1084916A priority patent/JPH0686441B2/ja
Priority to DE8989400935T priority patent/DE68906705T2/de
Priority to EP89400935A priority patent/EP0336841B1/fr
Priority to AT89400935T priority patent/ATE89823T1/de
Priority to CA000595731A priority patent/CA1308417C/fr
Priority to ES89400935T priority patent/ES2055119T3/es
Priority to KR1019890004540A priority patent/KR970009729B1/ko
Publication of FR2629819A1 publication Critical patent/FR2629819A1/fr
Application granted granted Critical
Publication of FR2629819B1 publication Critical patent/FR2629819B1/fr
Priority to GR930400035T priority patent/GR3007982T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR8804513A 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii Expired - Lifetime FR2629819B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR8804513A FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US07/331,758 US4924012A (en) 1988-04-06 1989-04-03 Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
IL89831A IL89831A (en) 1988-04-06 1989-04-03 Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
ZA892474A ZA892474B (en) 1988-04-06 1989-04-04 Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
AU32426/89A AU618333B2 (en) 1988-04-06 1989-04-04 Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
DE8989400935T DE68906705T2 (de) 1988-04-06 1989-04-05 Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii.
JP1084916A JPH0686441B2 (ja) 1988-04-06 1989-04-05 バカチン１１１および１０―デアセチルバカチン１１１の誘導体を調製する方法
EP89400935A EP0336841B1 (fr) 1988-04-06 1989-04-05 Procédé de préparation de dérivés de la baccatine III et de la désacétyl-10 baccatine III
AT89400935T ATE89823T1 (de) 1988-04-06 1989-04-05 Verfahren zur herstellung von baccatin-iiiderivaten und von desacetyl-10-baccatin-iii.
CA000595731A CA1308417C (fr) 1988-04-06 1989-04-05 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
ES89400935T ES2055119T3 (es) 1988-04-06 1989-04-05 Procedimiento para la preparacion de derivados de la bacatina iii y de la desacetil-10 bacatina iii.
KR1019890004540A KR970009729B1 (ko) 1988-04-06 1989-04-06 박카틴 ⅲ 및 10-데아세틸박카틴 ⅲ의 유도체를 제조하는 방법.
GR930400035T GR3007982T3 (enExample) 1988-04-06 1993-05-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8804513A FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Publications (2)

Publication Number Publication Date
FR2629819A1 FR2629819A1 (fr) 1989-10-13
FR2629819B1 true FR2629819B1 (fr) 1990-11-16

Family

ID=9364992

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8804513A Expired - Lifetime FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Country Status (13)

Country Link
US (1) US4924012A (enExample)
EP (1) EP0336841B1 (enExample)
JP (1) JPH0686441B2 (enExample)
KR (1) KR970009729B1 (enExample)
AT (1) ATE89823T1 (enExample)
AU (1) AU618333B2 (enExample)
CA (1) CA1308417C (enExample)
DE (1) DE68906705T2 (enExample)
ES (1) ES2055119T3 (enExample)
FR (1) FR2629819B1 (enExample)
GR (1) GR3007982T3 (enExample)
IL (1) IL89831A (enExample)
ZA (1) ZA892474B (enExample)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5304670A (en) * 1989-08-23 1994-04-19 Centre National De La Recherche Scientifique Process for the enantioselective preparation of phenylisoserine derivatives
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2679557B1 (fr) * 1991-07-25 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent.
FR2671799B1 (fr) † 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5194635A (en) * 1991-03-18 1993-03-16 Virginia Tech Intellectual Properties, Inc. Rearranged taxol compounds and method of using in testing of in vivo activity
CA2072400C (en) 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5481010A (en) * 1991-07-16 1996-01-02 Centre National De La Recherche Scientifique 7-deacetoxy beccatine IV derivative and preparation and use thereof
WO1993002064A1 (fr) * 1991-07-16 1993-02-04 Centre National De La Recherche Scientifique (Cnrs) Nouveau derive de la 7-desacetoxy baccatine iv, sa preparation et son emploi
FR2680506B1 (fr) * 1991-08-19 1994-09-02 Rhone Poulenc Rorer Sa Procede de preparation de derives de la beta-phenylisoserine et leur utilisation.
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
KR100252493B1 (ko) * 1991-09-23 2000-05-01 플로리다 금속알콕시드 및 베타-락탐을 사용한 치환된 이소세린 에스테르의 제조방법
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
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US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
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US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
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IL89831A0 (en) 1989-12-15
KR890016029A (ko) 1989-11-28
ATE89823T1 (de) 1993-06-15
ZA892474B (en) 1989-12-27
DE68906705D1 (de) 1993-07-01
GR3007982T3 (enExample) 1993-08-31
JPH01305077A (ja) 1989-12-08
EP0336841B1 (fr) 1993-05-26
EP0336841A1 (fr) 1989-10-11
AU618333B2 (en) 1991-12-19
ES2055119T3 (es) 1994-08-16
KR970009729B1 (ko) 1997-06-17
IL89831A (en) 1992-12-01
CA1308417C (fr) 1992-10-06
FR2629819A1 (fr) 1989-10-13
AU3242689A (en) 1989-10-12
JPH0686441B2 (ja) 1994-11-02
US4924012A (en) 1990-05-08
DE68906705T2 (de) 1993-09-16

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