DE68906705T2 - Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii. - Google Patents

Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii.

Info

Publication number
DE68906705T2
DE68906705T2 DE8989400935T DE68906705T DE68906705T2 DE 68906705 T2 DE68906705 T2 DE 68906705T2 DE 8989400935 T DE8989400935 T DE 8989400935T DE 68906705 T DE68906705 T DE 68906705T DE 68906705 T2 DE68906705 T2 DE 68906705T2
Authority
DE
Germany
Prior art keywords
iii
baccatin
desacetyl
producing
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8989400935T
Other languages
English (en)
Other versions
DE68906705D1 (de
Inventor
Michel Colin
Daniel Guenard
Francoise Gueritte-Voegelein
Pierre Potier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of DE68906705D1 publication Critical patent/DE68906705D1/de
Application granted granted Critical
Publication of DE68906705T2 publication Critical patent/DE68906705T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE8989400935T 1988-04-06 1989-04-05 Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii. Expired - Lifetime DE68906705T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8804513A FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Publications (2)

Publication Number Publication Date
DE68906705D1 DE68906705D1 (de) 1993-07-01
DE68906705T2 true DE68906705T2 (de) 1993-09-16

Family

ID=9364992

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989400935T Expired - Lifetime DE68906705T2 (de) 1988-04-06 1989-04-05 Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii.

Country Status (13)

Country Link
US (1) US4924012A (de)
EP (1) EP0336841B1 (de)
JP (1) JPH0686441B2 (de)
KR (1) KR970009729B1 (de)
AT (1) ATE89823T1 (de)
AU (1) AU618333B2 (de)
CA (1) CA1308417C (de)
DE (1) DE68906705T2 (de)
ES (1) ES2055119T3 (de)
FR (1) FR2629819B1 (de)
GR (1) GR3007982T3 (de)
IL (1) IL89831A (de)
ZA (1) ZA892474B (de)

Families Citing this family (136)

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FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
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US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5350866A (en) * 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
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US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
US5939561A (en) * 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
ATE181551T1 (de) * 1992-04-17 1999-07-15 Abbott Lab Taxol-derivate
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FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol

Also Published As

Publication number Publication date
FR2629819A1 (fr) 1989-10-13
KR890016029A (ko) 1989-11-28
AU618333B2 (en) 1991-12-19
ZA892474B (en) 1989-12-27
DE68906705D1 (de) 1993-07-01
FR2629819B1 (fr) 1990-11-16
IL89831A (en) 1992-12-01
ES2055119T3 (es) 1994-08-16
IL89831A0 (en) 1989-12-15
KR970009729B1 (ko) 1997-06-17
JPH0686441B2 (ja) 1994-11-02
ATE89823T1 (de) 1993-06-15
GR3007982T3 (de) 1993-08-31
AU3242689A (en) 1989-10-12
EP0336841B1 (de) 1993-05-26
JPH01305077A (ja) 1989-12-08
US4924012A (en) 1990-05-08
EP0336841A1 (de) 1989-10-11
CA1308417C (fr) 1992-10-06

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