ES2011462B3 - Un procedimiento para la produccion de un glicosido de antraciclina. - Google Patents

Un procedimiento para la produccion de un glicosido de antraciclina.

Info

Publication number
ES2011462B3
ES2011462B3 ES87102446T ES87102446T ES2011462B3 ES 2011462 B3 ES2011462 B3 ES 2011462B3 ES 87102446 T ES87102446 T ES 87102446T ES 87102446 T ES87102446 T ES 87102446T ES 2011462 B3 ES2011462 B3 ES 2011462B3
Authority
ES
Spain
Prior art keywords
anthracicline
glycoside
procedure
production
mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87102446T
Other languages
English (en)
Inventor
Giuseppe Cassinelli
Arpad Grein
Sergio Merli
Giovanni Rivola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of ES2011462B3 publication Critical patent/ES2011462B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES87102446T 1986-03-13 1987-02-20 Un procedimiento para la produccion de un glicosido de antraciclina. Expired - Lifetime ES2011462B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868606204A GB8606204D0 (en) 1986-03-13 1986-03-13 Biosynthetic anthracyclines

Publications (1)

Publication Number Publication Date
ES2011462B3 true ES2011462B3 (es) 1990-01-16

Family

ID=10594529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87102446T Expired - Lifetime ES2011462B3 (es) 1986-03-13 1987-02-20 Un procedimiento para la produccion de un glicosido de antraciclina.

Country Status (8)

Country Link
US (1) US4942155A (es)
EP (1) EP0239774B1 (es)
JP (1) JP2504450B2 (es)
AT (1) ATE44154T1 (es)
DE (1) DE3760262D1 (es)
ES (1) ES2011462B3 (es)
GB (1) GB8606204D0 (es)
GR (1) GR3000082T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2779652B2 (ja) * 1988-12-27 1998-07-23 武田薬品工業株式会社 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物
RU2038800C1 (ru) * 1993-05-05 1995-07-09 Научно-производственное предприятие "Биотехнивест" Биопрепарат "риал" и способ кормления животных, птицы и пчел
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
GB9727546D0 (en) 1997-12-31 1998-03-18 Pharmacia & Upjohn Spa Anthracycline glycosides
CN101798328B (zh) * 2010-03-20 2012-05-23 山东新时代药业有限公司 一种柔红霉素发酵液提取纯化工艺改进方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
JPS6297A (ja) * 1985-06-24 1987-01-06 Microbial Chem Res Found アントラサイクリン化合物

Also Published As

Publication number Publication date
JP2504450B2 (ja) 1996-06-05
GR3000082T3 (en) 1990-10-31
US4942155A (en) 1990-07-17
EP0239774A1 (en) 1987-10-07
GB8606204D0 (en) 1986-04-16
ATE44154T1 (de) 1989-07-15
JPS62265291A (ja) 1987-11-18
EP0239774B1 (en) 1989-06-21
DE3760262D1 (en) 1989-07-27

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