FR2629819B1 - Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii - Google Patents

Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Info

Publication number
FR2629819B1
FR2629819B1 FR8804513A FR8804513A FR2629819B1 FR 2629819 B1 FR2629819 B1 FR 2629819B1 FR 8804513 A FR8804513 A FR 8804513A FR 8804513 A FR8804513 A FR 8804513A FR 2629819 B1 FR2629819 B1 FR 2629819B1
Authority
FR
France
Prior art keywords
baccatin iii
iii
desacetyl
preparation
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8804513A
Other languages
English (en)
French (fr)
Other versions
FR2629819A1 (fr
Inventor
Michel Colin
Daniel Guenard
Francoise Gueritte-Voegelein
Pierre Potier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Priority to FR8804513A priority Critical patent/FR2629819B1/fr
Priority to US07/331,758 priority patent/US4924012A/en
Priority to IL89831A priority patent/IL89831A/xx
Priority to ZA892474A priority patent/ZA892474B/xx
Priority to AU32426/89A priority patent/AU618333B2/en
Priority to ES89400935T priority patent/ES2055119T3/es
Priority to EP89400935A priority patent/EP0336841B1/fr
Priority to DE8989400935T priority patent/DE68906705T2/de
Priority to AT89400935T priority patent/ATE89823T1/de
Priority to JP1084916A priority patent/JPH0686441B2/ja
Priority to CA000595731A priority patent/CA1308417C/fr
Priority to KR1019890004540A priority patent/KR970009729B1/ko
Publication of FR2629819A1 publication Critical patent/FR2629819A1/fr
Application granted granted Critical
Publication of FR2629819B1 publication Critical patent/FR2629819B1/fr
Priority to GR930400035T priority patent/GR3007982T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
FR8804513A 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii Expired - Lifetime FR2629819B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR8804513A FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US07/331,758 US4924012A (en) 1988-04-06 1989-04-03 Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III
IL89831A IL89831A (en) 1988-04-06 1989-04-03 Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
AU32426/89A AU618333B2 (en) 1988-04-06 1989-04-04 Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
ZA892474A ZA892474B (en) 1988-04-06 1989-04-04 Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
EP89400935A EP0336841B1 (fr) 1988-04-06 1989-04-05 Procédé de préparation de dérivés de la baccatine III et de la désacétyl-10 baccatine III
ES89400935T ES2055119T3 (es) 1988-04-06 1989-04-05 Procedimiento para la preparacion de derivados de la bacatina iii y de la desacetil-10 bacatina iii.
DE8989400935T DE68906705T2 (de) 1988-04-06 1989-04-05 Verfahren zur herstellung von baccatin-iii-derivaten und von desacetyl-10-baccatin-iii.
AT89400935T ATE89823T1 (de) 1988-04-06 1989-04-05 Verfahren zur herstellung von baccatin-iiiderivaten und von desacetyl-10-baccatin-iii.
JP1084916A JPH0686441B2 (ja) 1988-04-06 1989-04-05 バカチン１１１および１０―デアセチルバカチン１１１の誘導体を調製する方法
CA000595731A CA1308417C (fr) 1988-04-06 1989-04-05 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
KR1019890004540A KR970009729B1 (ko) 1988-04-06 1989-04-06 박카틴 ⅲ 및 10-데아세틸박카틴 ⅲ의 유도체를 제조하는 방법.
GR930400035T GR3007982T3 (OSRAM) 1988-04-06 1993-05-27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8804513A FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Publications (2)

Publication Number Publication Date
FR2629819A1 FR2629819A1 (fr) 1989-10-13
FR2629819B1 true FR2629819B1 (fr) 1990-11-16

Family

ID=9364992

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8804513A Expired - Lifetime FR2629819B1 (fr) 1988-04-06 1988-04-06 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Country Status (13)

Country Link
US (1) US4924012A (OSRAM)
EP (1) EP0336841B1 (OSRAM)
JP (1) JPH0686441B2 (OSRAM)
KR (1) KR970009729B1 (OSRAM)
AT (1) ATE89823T1 (OSRAM)
AU (1) AU618333B2 (OSRAM)
CA (1) CA1308417C (OSRAM)
DE (1) DE68906705T2 (OSRAM)
ES (1) ES2055119T3 (OSRAM)
FR (1) FR2629819B1 (OSRAM)
GR (1) GR3007982T3 (OSRAM)
IL (1) IL89831A (OSRAM)
ZA (1) ZA892474B (OSRAM)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5304670A (en) * 1989-08-23 1994-04-19 Centre National De La Recherche Scientifique Process for the enantioselective preparation of phenylisoserine derivatives
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
FR2679557B1 (fr) * 1991-07-25 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent.
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2671799B1 (fr) † 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5194635A (en) * 1991-03-18 1993-03-16 Virginia Tech Intellectual Properties, Inc. Rearranged taxol compounds and method of using in testing of in vivo activity
CA2072400C (en) * 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
WO1993002064A1 (fr) * 1991-07-16 1993-02-04 Centre National De La Recherche Scientifique (Cnrs) Nouveau derive de la 7-desacetoxy baccatine iv, sa preparation et son emploi
US5481010A (en) * 1991-07-16 1996-01-02 Centre National De La Recherche Scientifique 7-deacetoxy beccatine IV derivative and preparation and use thereof
FR2680506B1 (fr) * 1991-08-19 1994-09-02 Rhone Poulenc Rorer Sa Procede de preparation de derives de la beta-phenylisoserine et leur utilisation.
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
CA2254273C (en) * 1991-09-23 2003-03-25 Florida State University Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams
US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
SG46582A1 (en) * 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
CA2087359A1 (en) * 1992-01-15 1993-07-16 Ramesh N. Patel Enzymatic processes for resolution of enantiomeric mixtures of compoundsuseful as intermediates in the preparation of taxanes
FR2687145B1 (fr) * 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux anhydrides d'acides, leur preparation et leur emplot et
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
US5939561A (en) * 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
JPH07505887A (ja) * 1992-04-17 1995-06-29 アボツト・ラボラトリーズ タキソール誘導体
CA2136213A1 (en) * 1992-05-21 1993-11-25 Richard N. Arteca Cultured taxu tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5470866A (en) * 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
FR2696462B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2696463B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5420337A (en) * 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
US5279949A (en) * 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
EP0679156B1 (en) * 1993-01-15 2000-05-24 Florida State University Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
US5688517A (en) * 1993-01-29 1997-11-18 Napro Biotherapeutics, Inc. Method for assessing sensitivity of tumor cells to cephalomannine and 10-deacetyltaxol
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
ATE253563T1 (de) * 1993-02-05 2003-11-15 Bryn Mawr College Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
US5684175A (en) * 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
EP0687260B1 (en) * 1993-03-05 2003-02-19 Florida State University Process for the preparation of 9-desoxotaxanes
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
EP0703909B1 (en) * 1993-06-11 2000-04-26 PHARMACIA & UPJOHN COMPANY Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
US5516676A (en) * 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US5523219A (en) * 1993-06-15 1996-06-04 Bristol-Myers Squibb Company Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
FR2707165B1 (fr) * 1993-07-06 1995-08-11 Rhone Poulenc Rorer Sa Application des taxoides au traitement de maladies d'origine parasitaire .
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US6005120A (en) * 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5602272A (en) * 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5675025A (en) * 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
US6107497A (en) * 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US6228955B1 (en) 1996-04-19 2001-05-08 Chirotech Technology, Ltd. Asymmetric epoxides, their synthesis and use
CN1221412A (zh) * 1996-05-06 1999-06-30 佛罗里达州立大学 1－脱氧浆果赤霉素ⅲ,1－脱氧紫杉醇和1－脱氧紫杉醇类似物及其制备方法
JP2000510832A (ja) 1996-05-08 2000-08-22 ファルマシア・アンド・アップジョン・カンパニー タキソールの製法
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
EP1019347B1 (en) * 1997-08-21 2003-03-19 Florida State University Method for the synthesis of taxanes
DK1068192T3 (da) * 1998-01-14 2002-10-14 Bristol Myers Squibb Co Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanol
AU2187799A (en) * 1998-01-26 1999-08-09 Hanmi Pharmaceutical Co., Ltd. Novel taxaneterpine compounds
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
IL139316A0 (en) 1998-05-01 2001-11-25 Napro Biotherapeutics Inc Methods and intermediate compounds for preparing paclitaxel
US6066749A (en) * 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6048990A (en) * 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2002024179A2 (en) 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US6479679B1 (en) 2001-04-25 2002-11-12 Napro Biotherapeutics, Inc. Two-step conversion of protected taxane ester to paclitaxel
US6452025B1 (en) 2001-04-25 2002-09-17 Napro Biotherapeutics, Inc. Three-step conversion of protected taxane ester to paclitaxel
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
PL368945A1 (en) 2001-11-30 2005-04-04 Bristol-Myers Squibb Company Paclitaxel solvates
GB0200657D0 (en) * 2002-01-12 2002-02-27 Antisoma Plc Cancer treatment
CN1703409A (zh) * 2002-10-09 2005-11-30 加拿大植原药物公司 新紫杉烷和用途及制备方法
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US20050192445A1 (en) * 2004-03-01 2005-09-01 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
CA2667416C (en) * 2006-10-20 2013-12-17 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
GB0701523D0 (en) * 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives
EP2285792A2 (en) * 2008-05-07 2011-02-23 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
US8637466B2 (en) 2008-08-11 2014-01-28 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
GB0907973D0 (en) 2009-05-08 2009-06-24 Modern Biosciences Plc Combination therapy
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
AU2011274229A1 (en) 2010-07-02 2013-01-10 Angiochem Inc. Short and D-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012117417A1 (en) * 2011-02-28 2012-09-07 Shilpa Medicare Limited Process for preparing (2r, 3s) 2-benzyloxy-3-tert-butoxy carbonyl amino-3-phenyl propionic acid
EP2697211A4 (en) 2011-04-01 2014-08-13 Shilpa Medicare Ltd PROCESS FOR THE PREPARATION OF DOCETAXEL AND ITS HYDRATE
US11566189B2 (en) 2020-05-22 2023-01-31 ExxonMobil Technology and Engineering Company Process to produce high paraffinic diesel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol

Also Published As

Publication number Publication date
AU3242689A (en) 1989-10-12
DE68906705T2 (de) 1993-09-16
IL89831A0 (en) 1989-12-15
ES2055119T3 (es) 1994-08-16
EP0336841A1 (fr) 1989-10-11
KR890016029A (ko) 1989-11-28
IL89831A (en) 1992-12-01
KR970009729B1 (ko) 1997-06-17
ATE89823T1 (de) 1993-06-15
DE68906705D1 (de) 1993-07-01
AU618333B2 (en) 1991-12-19
JPH0686441B2 (ja) 1994-11-02
JPH01305077A (ja) 1989-12-08
US4924012A (en) 1990-05-08
CA1308417C (fr) 1992-10-06
GR3007982T3 (OSRAM) 1993-08-31
FR2629819A1 (fr) 1989-10-13
EP0336841B1 (fr) 1993-05-26
ZA892474B (en) 1989-12-27

Similar Documents

Publication Publication Date Title
FR2629819B1 (fr) Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) Procede de preparation du taxol
FI915488A0 (fi) Kondenserade heterocykliska foereningar, deras framstaellning och anvaendning.
ES2014451B3 (es) Procedimiento para la obtencion de (2,2)-paraciclofano y derivados.
NO922185L (no) 1-metylkarbapenemderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som antibiotika
SE9003476L (sv) Novel isoindole derivatives and salts thereof, process for producing the same and antitumor agent comprising the same
FR2590255B1 (fr) Procede de preparation de derives de la pteridine
ES8706148A1 (es) Un procedimiento para preparar nuevos derivados de carbapenem.
DE3770359D1 (de) 6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
KR890012991A (ko) 광학활성을 갖는 4-옥소-1-벤조피란-2-카르복시산 유도체 및 중간체의 제법
NO900636D0 (no) Fremgangsmaate for fremstilling av indolderivater.
FI870176A0 (fi) Nya foereningar och deras framstaellningsfoerfaranden.
SE8803765L (sv) Nya isopolypeptider samt foerfarande foer framstaellning av desamma
IT1237529B (it) Composti spiro-indolino-ossazine con caratteristiche fotocromatiche e fotosensibilizzatrici e procedimento per la loro preparazione
ATE84720T1 (de) Verwendung von adenosinderivaten zur herstellung von arzneimitteln mit immunstimulierender wirkung.
ES2011462B3 (es) Un procedimiento para la produccion de un glicosido de antraciclina.
DE3880088D1 (de) Ethylierte avermectine.
DE3785895D1 (de) Oxiran-pseudooligosaccharide, verfahren zu deren herstellung, deren verwendung und pharmazeutische praeparate.
PT90920A (pt) Processo para a producao de antocianidinas e dos seus intermediarios
ES2052812T3 (es) Un procedimiento para la preparacion de derivados de pirrolizina.
AR241133Q (es) Procedimiento para la obtencion de nuevos derivados de naftaleno
RO95697A2 (ro) Derivati de 1,1'-oxibis(4n-fenoxiacetamido)benzen si procedeu de preparare a acestora
SE9002445D0 (sv) Nytt cyklobutanderivat och foerfarande foer framstaellning av detsamma
DK446985A (da) Fremgangsmaade til fremstilling af 3,3'',4''-triacyltylosin-derivater
ES2053034T3 (es) Un procedimiento para la preparacion de butalactina y su empleo como producto farmaceutico.

Legal Events

Date Code Title Description
ST Notification of lapse