FR2571966B1 - Compositions therapeutiques contenant des anthracyclines-glucosides. - Google Patents

Compositions therapeutiques contenant des anthracyclines-glucosides.

Info

Publication number
FR2571966B1
FR2571966B1 FR8515596A FR8515596A FR2571966B1 FR 2571966 B1 FR2571966 B1 FR 2571966B1 FR 8515596 A FR8515596 A FR 8515596A FR 8515596 A FR8515596 A FR 8515596A FR 2571966 B1 FR2571966 B1 FR 2571966B1
Authority
FR
France
Prior art keywords
glucosides
compositions containing
therapeutic compositions
containing anthracyclines
anthracyclines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8515596A
Other languages
English (en)
French (fr)
Other versions
FR2571966A1 (fr
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2571966A1 publication Critical patent/FR2571966A1/fr
Application granted granted Critical
Publication of FR2571966B1 publication Critical patent/FR2571966B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8515596A 1984-10-22 1985-10-21 Compositions therapeutiques contenant des anthracyclines-glucosides. Expired FR2571966B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
FR2571966A1 FR2571966A1 (fr) 1986-04-25
FR2571966B1 true FR2571966B1 (fr) 1988-04-15

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8515596A Expired FR2571966B1 (fr) 1984-10-22 1985-10-21 Compositions therapeutiques contenant des anthracyclines-glucosides.

Country Status (35)

Country Link
US (4) US4675311A (Direct)
JP (1) JPH0611700B2 (Direct)
KR (1) KR920005813B1 (Direct)
CN (1) CN85107562B (Direct)
AT (1) AT401345B (Direct)
AU (1) AU572003B2 (Direct)
BE (1) BE903484A (Direct)
BG (1) BG60934B2 (Direct)
CA (1) CA1248453A (Direct)
CH (1) CH667594A5 (Direct)
CS (1) CS270421B2 (Direct)
DE (1) DE3536896C2 (Direct)
DK (1) DK165620C (Direct)
ES (1) ES8605374A1 (Direct)
FI (2) FI853913A7 (Direct)
FR (1) FR2571966B1 (Direct)
GB (2) GB8426672D0 (Direct)
GR (1) GR852549B (Direct)
HK (1) HK94390A (Direct)
HU (1) HU197988B (Direct)
IE (1) IE56992B1 (Direct)
IL (1) IL76732A (Direct)
IT (1) IT1186779B (Direct)
MY (1) MY103956A (Direct)
NL (1) NL191308C (Direct)
NO (1) NO170616C (Direct)
NZ (1) NZ213885A (Direct)
PH (1) PH23982A (Direct)
PT (1) PT81347B (Direct)
RU (2) RU1836088C (Direct)
SE (1) SE467520B (Direct)
SG (1) SG80290G (Direct)
UA (2) UA34419C2 (Direct)
YU (1) YU46160B (Direct)
ZA (1) ZA858033B (Direct)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
KR0158672B1 (en) * 1986-12-05 1998-12-01 Erba Carlo Spa Injectable ready-to-use solutions containing an antitumour anthracycline glycoside
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
JP2001513078A (ja) 1996-12-30 2001-08-28 バテル・メモリアル・インスティテュート 吸入により新生物を治療する製剤とその方法
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
PT1478339E (pt) 2002-02-22 2008-09-05 Schering Corp Formulações farmacêuticas de agentes antineoplásticos, em particular temozolomida, processos para a sua produção e utilização
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
RU2341530C2 (ru) * 2003-07-02 2008-12-20 Солакс Корпорейшн Термостойкий кристаллический гидрохлорид эпирубицина и способ его получения
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US7314862B2 (en) * 2003-09-25 2008-01-01 Astellas Pharma Inc. Antitumor agent
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006122309A2 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
EP1921919B1 (en) 2005-07-14 2012-04-04 Lithera, Inc. Sustained release enhanced lipolytic formulation for regional adipose tissue treatment
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CN101743020A (zh) * 2007-05-16 2010-06-16 Ktb肿瘤研究有限责任公司 低粘度蒽环制剂
JP4456177B2 (ja) * 2007-09-04 2010-04-28 明治製菓株式会社 注射剤、注射液および注射用キット製剤
BRPI0818860A2 (pt) * 2007-10-26 2015-04-22 Pfizer Prod Inc Idarubicina para o tratamento de linfoma em um cão
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
CA2786618C (en) * 2010-01-15 2016-04-12 Lithera, Inc. Lyophilized cake formulations
CA2815374A1 (en) 2010-11-24 2012-06-07 Lithera, Inc. Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
DK2931042T3 (da) 2012-12-13 2021-06-07 Cytrx Corp Anthracyclinformuleringer
CN113842392A (zh) 2013-06-05 2021-12-28 西特克斯公司 用于治疗癌症的细胞毒素剂

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
FI75834C (fi) * 1982-05-24 1988-08-08 Erba Farmitalia Foerfarande foer framstaellning av antracyklinglykosidfoereningar.
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
GR79729B (Direct) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Also Published As

Publication number Publication date
AT401345B (de) 1996-08-26
GR852549B (Direct) 1986-02-24
DE3536896C2 (de) 1996-11-14
KR860003014A (ko) 1986-05-19
PH23982A (en) 1990-02-09
YU164485A (en) 1987-10-31
GB2165751B (en) 1988-08-17
RU1836088C (ru) 1993-08-23
FI853913A7 (fi) 1986-04-23
GB8525709D0 (en) 1985-11-20
FI86252B (fi) 1992-04-30
DK481585A (da) 1986-04-23
JPH0611700B2 (ja) 1994-02-16
IE852593L (en) 1986-04-22
CS270421B2 (en) 1990-06-13
SE8504945D0 (sv) 1985-10-21
BE903484A (fr) 1986-04-21
IE56992B1 (en) 1992-02-26
HU197988B (en) 1989-07-28
NL8502869A (nl) 1986-05-16
SE467520B (sv) 1992-08-03
SE8504945L (sv) 1986-04-23
ES8605374A1 (es) 1986-03-16
FI854035A0 (fi) 1985-10-16
DK481585D0 (da) 1985-10-21
FI86252C (fi) 1992-08-10
DE3536896A1 (de) 1986-04-24
HUT40759A (en) 1987-02-27
CS756585A2 (en) 1989-11-14
YU46160B (sh) 1993-05-28
BG60934B2 (bg) 1996-06-28
KR920005813B1 (ko) 1992-07-20
IT8522507A0 (it) 1985-10-16
FR2571966A1 (fr) 1986-04-25
FI853913A0 (fi) 1985-10-08
DK165620B (da) 1992-12-28
NZ213885A (en) 1988-05-30
PT81347A (en) 1985-11-01
IL76732A (en) 1989-07-31
US4675311A (en) 1987-06-23
NO854194L (no) 1986-04-23
ES547578A0 (es) 1986-03-16
AU4880585A (en) 1986-05-01
US4840938A (en) 1989-06-20
GB8426672D0 (en) 1984-11-28
JPS61246129A (ja) 1986-11-01
FI854035L (fi) 1986-04-23
ATA303285A (de) 1996-01-15
UA34419C2 (uk) 2001-03-15
IT1186779B (it) 1987-12-16
MY103956A (en) 1993-10-30
GB2165751A (en) 1986-04-23
SG80290G (en) 1990-11-23
IL76732A0 (en) 1986-02-28
AU572003B2 (en) 1988-04-28
PT81347B (pt) 1987-11-11
NL191308B (nl) 1994-12-16
CA1248453A (en) 1989-01-10
UA19169A (uk) 1997-12-25
ZA858033B (en) 1986-06-25
CH667594A5 (de) 1988-10-31
HK94390A (en) 1990-11-23
DK165620C (da) 1993-06-01
CN85107562B (zh) 1988-06-01
NO170616B (no) 1992-08-03
NL191308C (nl) 1995-05-16
CN85107562A (zh) 1986-07-23
US5091372A (en) 1992-02-25
US5091373A (en) 1992-02-25
RU2101018C1 (ru) 1998-01-10
NO170616C (no) 1992-11-11

Similar Documents

Publication Publication Date Title
FR2571966B1 (fr) Compositions therapeutiques contenant des anthracyclines-glucosides.
FI862094L (fi) Bornerande terapeutisk komposition.
FI840662L (fi) Tvaettmedelkompositioner.
FI850323L (fi) Heterocykliska kompositioner.
DE3585704D1 (de) Thermoplastische-elastomere-zusammensetzung.
DE3583583D1 (de) Aetzzusammensetzung.
DE3668414D1 (de) Antidiarrhoee-zusammensetzungen.
FI873087A0 (fi) Desensiterande dentalkomposition.
DE3684564D1 (de) Veterinaere zusammensetzungen.
DE3578631D1 (de) Polyorganosiloxanzusammensetzungen.
DE3876490D1 (de) Korrosionsinhibierende zusammensetzung.
DE3669105D1 (de) Therapeutische zusammensetzung.
DE3582194D1 (de) Detergens-zusammensetzungen.
NO155225C (no) Tannbehandlingspreparat inneholdende fluoridioner.
NO162611C (no) "stoept" eksplosiv sammensetning.
DE3689646D1 (de) Antiseptische zusammensetzungen.
IT8423676A0 (it) Composizioni cosmetiche dermotrope.
DE3584226D1 (de) Zusammensetzung.
FR2590169B1 (fr) Composition cosmetique contenant des bio-stimulines
DE3864865D1 (de) Duftzusammensetzung.
FR2609392B1 (fr) Compositions pharmaceutiques contenant des pyranoquinoleines
IT1216056B (it) Composizioni farmaceutiche contenenti timosina alfa 1.
DE3669656D1 (de) Azanaphthalene enthaltende arzneimittelzusammensetzungen.
DE3762800D1 (de) Benzhydrylthiomethan-derivate enthaltende therapeutische zusammensetzungen.
DE3577656D1 (de) Pharmazeutische zusammensetzungen von ceftazidim.

Legal Events

Date Code Title Description
TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0091, 920424

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0091, 851021

CL Concession to grant licences
TP Transmission of property
CD Change of name or company name
CD Change of name or company name
TP Transmission of property