FR2540869B1 - Procede pour la preparation de derives hydroxyles de la vitamine d2 et produits intermediaires utilises dans ce procede - Google Patents

Procede pour la preparation de derives hydroxyles de la vitamine d2 et produits intermediaires utilises dans ce procede

Info

Publication number
FR2540869B1
FR2540869B1 FR838314942A FR8314942A FR2540869B1 FR 2540869 B1 FR2540869 B1 FR 2540869B1 FR 838314942 A FR838314942 A FR 838314942A FR 8314942 A FR8314942 A FR 8314942A FR 2540869 B1 FR2540869 B1 FR 2540869B1
Authority
FR
France
Prior art keywords
vitamin
preparation
intermediate products
products used
hydroxyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR838314942A
Other languages
English (en)
Other versions
FR2540869A1 (fr
Inventor
Hector F De Luca
Heinrich K Schnoes
Jacek W Morzycki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2540869A1 publication Critical patent/FR2540869A1/fr
Application granted granted Critical
Publication of FR2540869B1 publication Critical patent/FR2540869B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
FR838314942A 1982-09-20 1983-09-20 Procede pour la preparation de derives hydroxyles de la vitamine d2 et produits intermediaires utilises dans ce procede Expired FR2540869B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/420,191 US4448721A (en) 1982-09-20 1982-09-20 Hydroxyvitamin D2 compounds and process for preparing same

Publications (2)

Publication Number Publication Date
FR2540869A1 FR2540869A1 (fr) 1984-08-17
FR2540869B1 true FR2540869B1 (fr) 1988-04-15

Family

ID=23665448

Family Applications (3)

Application Number Title Priority Date Filing Date
FR838314942A Expired FR2540869B1 (fr) 1982-09-20 1983-09-20 Procede pour la preparation de derives hydroxyles de la vitamine d2 et produits intermediaires utilises dans ce procede
FR8415789A Expired FR2555172B1 (fr) 1982-09-20 1984-10-15 5,7-diene steroide, previtamine correspondante et isomere
FR848415790A Expired FR2555173B1 (fr) 1982-09-20 1984-10-15 25-oh previtamine d2 et 5,7-diene 25 hydroxyle correspondant

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR8415789A Expired FR2555172B1 (fr) 1982-09-20 1984-10-15 5,7-diene steroide, previtamine correspondante et isomere
FR848415790A Expired FR2555173B1 (fr) 1982-09-20 1984-10-15 25-oh previtamine d2 et 5,7-diene 25 hydroxyle correspondant

Country Status (11)

Country Link
US (1) US4448721A (fr)
EP (1) EP0119251A1 (fr)
JP (6) JPS59501746A (fr)
CA (1) CA1283422C (fr)
CH (1) CH671222A5 (fr)
DE (2) DE3390212T1 (fr)
FR (3) FR2540869B1 (fr)
GB (2) GB2127023B (fr)
IE (1) IE56174B1 (fr)
IL (1) IL69763A (fr)
WO (1) WO1984001155A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036061A (en) * 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US5120722A (en) * 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
US4588716A (en) * 1984-05-04 1986-05-13 Wisconsin Alumni Research Foundation Method for treating metabolic bone disease in mammals
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4857518A (en) * 1984-10-04 1989-08-15 Wisconsin Alumni Research Foundation Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same
EP0197949A1 (fr) * 1984-10-04 1986-10-22 Wisconsin Alumni Research Foundation Derives de vitamine d et leurs procedes de preparation
US5225579A (en) * 1988-03-16 1993-07-06 Hoxan Corporation Method of manufacturing vitamin D2, Vitamin D3, activated type vitamin D2, activated type vitamin D3, and their derivatives
IN171449B (fr) * 1990-02-14 1992-10-17 Wisconsin Alumni Res Found
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5063234A (en) * 1990-05-25 1991-11-05 Eli Lilly And Company Method of inhibiting demineralization of bone
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
EP0550702B1 (fr) * 1991-01-08 1999-05-06 Bone Care International, Inc. PROCEDES DE PREPARATION ET UTILISATION DE LA VITAMINE 1$g(a),24-DIHYDROXY D 2?
DE69318142T2 (de) * 1992-01-29 1998-09-17 Bone Care Int Inc 1 alpha-HYDROXY-24-(EPI)-VITAMIN D4
TW267161B (fr) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
NZ556354A (en) * 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7947682B2 (en) * 2004-12-29 2011-05-24 University Of Southern California Substituted N′-pyrrolo[1,2-a]quinoxalin-4-yl-hydrazides as anti-cancer agents
HUE056937T2 (hu) 2006-02-03 2022-04-28 Opko Renal Llc A D-vitamin elégtelenség és hiány kezelése 25-hidroxivitamin D2-vel és 25-hidroxivitamin D3-mal
WO2007120972A2 (fr) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Procede permettant de traiter l'anemie a hematies falciformes
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
PT2679228T (pt) 2006-06-21 2018-04-16 Opko Ireland Global Holdings Ltd Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d
PT2148684E (pt) 2007-04-25 2013-04-19 Cytochroma Inc Método de tratamento para a insuficiência e deficiência de vitamina d
KR101959952B1 (ko) 2007-04-25 2019-03-19 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
WO2009124210A1 (fr) 2008-04-02 2009-10-08 Cytochroma Inc. Procédés, compositions, utilisations, et kits utiles pour la carence en vitamine d et des troubles associés
EP2334640B1 (fr) * 2008-07-22 2015-12-23 Azad Pharmaceutical Ingredients AG Procédés de production de paricalcitol
EP2393494A1 (fr) * 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamines d3 et analogues de celles-ci pour soulagement des effets secondaires associés à une chimiothérapie
CA2770683C (fr) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamine d3 et ses analogues pour le traitement de l'alopecie
US11672809B2 (en) 2010-03-29 2023-06-13 Eirgen Pharma Ltd. Methods and compositions for reducing parathyroid levels
CA2698160C (fr) * 2010-03-30 2017-07-25 Alphora Research Inc. Doxercalciferol stabilise et procede pour le produire
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
AU2015298858A1 (en) 2014-08-07 2017-03-02 Opko Ireland Global Holdings Ltd. Adjunctive therapy with 25-hydroxyvitamin D
CA3018019A1 (fr) 2016-03-28 2017-10-26 Opko Ireland Global Holdings, Limited Procedes de traitement par la vitamine d
CN115947678B (zh) * 2023-03-10 2024-01-16 成都诺森医学检验有限公司 稳定同位素2h（d）标记25-羟基维生素d2的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1052283B (it) * 1968-07-01 1981-06-20 Wisconsin Alumni Res Found Processo per preparare composti del calciferolo e relativi composti
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US4105660A (en) * 1977-06-29 1978-08-08 Merck & Co., Inc. Preparation of 3β-hydroxy-27-norcholest-5,7-dien-25-one
US4145346A (en) * 1977-10-03 1979-03-20 Merck & Co., Inc. Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof
US4229358A (en) * 1978-07-26 1980-10-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4265822A (en) * 1979-09-10 1981-05-05 Wisconsin Alumni Research Foundation Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds
DE3048698A1 (de) * 1980-12-23 1982-07-15 Wisconsin Alumni Research Foundation, 53707 Madison, Wis. Verfahren zur herstellung einer 1(alpha)-hydroxylierten vitamin-d-verbindung, ausgehend von einer 5,6-trans-vitamin-d-verbindung

Also Published As

Publication number Publication date
IL69763A (en) 1987-01-30
FR2555173B1 (fr) 1989-04-07
FR2555173A1 (fr) 1985-05-24
JPH0518839B2 (fr) 1993-03-15
GB2127023B (en) 1987-07-08
CH671222A5 (fr) 1989-08-15
GB8325131D0 (en) 1983-10-19
DE3348322C2 (fr) 1991-07-25
DE3390212C2 (fr) 1991-10-31
JPH0434540B2 (fr) 1992-06-08
GB2142922B (en) 1986-08-28
JPH0435458B2 (fr) 1992-06-11
IL69763A0 (en) 1983-12-30
WO1984001155A1 (fr) 1984-03-29
EP0119251A1 (fr) 1984-09-26
GB2127023A (en) 1984-04-04
JPH02209888A (ja) 1990-08-21
DE3390212T1 (de) 1984-11-29
JPH02209887A (ja) 1990-08-21
JPS59501746A (ja) 1984-10-18
US4448721A (en) 1984-05-15
JPH0610187B2 (ja) 1994-02-09
JPH02209863A (ja) 1990-08-21
JPH02209862A (ja) 1990-08-21
JPH0518840B2 (fr) 1993-03-15
FR2540869A1 (fr) 1984-08-17
IE56174B1 (en) 1991-05-08
GB8417477D0 (en) 1984-08-15
JPH0443916B2 (fr) 1992-07-20
IE832203L (en) 1984-03-20
JPH02209864A (ja) 1990-08-21
FR2555172B1 (fr) 1987-08-07
GB2142922A (en) 1985-01-30
CA1283422C (fr) 1991-04-23
FR2555172A1 (fr) 1985-05-24

Similar Documents

Publication Publication Date Title
FR2540869B1 (fr) Procede pour la preparation de derives hydroxyles de la vitamine d2 et produits intermediaires utilises dans ce procede
MA23528A1 (fr) Procede de preparation de produits pharmaceutiques
RO90622A (fr) Procede pour la preparation des derives de pyperidine
PT77488B (fr) Procede de preparation de derives de phenyl-1-piperidino-2-propanol et de compositions pharmaceutiques les contenant
RO82216A (fr) Procede pour la preparation des derives de 3-aryle-5-tsothiazole
RO86851A (fr) Procede pour la preparation des derives de pyperazin-2-one
MC1527A1 (fr) Procede pour la preparation de derives de 1-sulfo-2-oxoazetidine
MC1982A1 (fr) Procede de preparation de derives de la didesoxycitidine
RO89235A (fr) Procede pour la preparation des derives de thilosine
MA23518A1 (fr) Procede de preparation de produits pharmaceutiques
RO93218A (fr) Procede pour la preparation des derives de 2-oxyndole
PT86874A (pt) Process for the preparation of cromona by products and of pharmaceutical compounds containing them
PT76768A (fr) Procede pour la preparation de derives de piperazine et de compositions pharmaceutiques avec les memes
RO90047A (fr) Procede pour la preparation des derives fluorures de la pyridine
MA21984A1 (fr) Procede pour la preparation de derives de quilinone .
RO85384A (fr) Procede de preparation des derives de la pyridine
FR2545824B1 (fr) Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
FR2511681B1 (fr) Procede pour la preparation de derives de 3-exo-methylenecephame
RO81930A (fr) Procede pour la preparation des derives de pyrimidone
MA22880A1 (fr) Procede de preparation de produits pharmaceutiques .
FR2549721B1 (fr) Procede et compositions pour la coloration des phaneres
BE889319A (fr) Procede pour la preparation de 5-aryldenehydantoines et produits obtenus
PT77286A (fr) Procede pour la preparation de derives de sulphamoilbenzophenone si bien que de compositions pharmaceutiques qui les contiennent
FR2583389B1 (fr) Chevalets pour ampoules de produits pharmaceutiques
FR2601019B1 (fr) Procede de preparation de derives de la moranoline