FR2496669A1 - Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments - Google Patents

Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments Download PDF

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Publication number
FR2496669A1
FR2496669A1 FR8027272A FR8027272A FR2496669A1 FR 2496669 A1 FR2496669 A1 FR 2496669A1 FR 8027272 A FR8027272 A FR 8027272A FR 8027272 A FR8027272 A FR 8027272A FR 2496669 A1 FR2496669 A1 FR 2496669A1
Authority
FR
France
Prior art keywords
formula
radical
products
product
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8027272A
Other languages
English (en)
French (fr)
Other versions
FR2496669B1 (
Inventor
Lucien Nedelec
Vesperto Torelli
Daniel Philibert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8027272A priority Critical patent/FR2496669A1/fr
Priority to IL64503A priority patent/IL64503A0/xx
Priority to ES507890A priority patent/ES8401989A1/es
Priority to ZA818673A priority patent/ZA818673B/xx
Priority to AT81401994T priority patent/ATE10004T1/de
Priority to DE8181401994T priority patent/DE3166872D1/de
Priority to EP81401994A priority patent/EP0055170B1/fr
Priority to MX761281A priority patent/MX155082A/es
Priority to SU813366202A priority patent/SU1301317A3/ru
Priority to FI814109A priority patent/FI77463C/fi
Priority to GR66857A priority patent/GR77629B/el
Priority to US06/332,842 priority patent/US4396614A/en
Priority to DK569281A priority patent/DK569281A/da
Priority to HU813907A priority patent/HU184974B/hu
Priority to PT74184A priority patent/PT74184B/pt
Priority to KR1019810005067A priority patent/KR870001937B1/ko
Priority to CA000392942A priority patent/CA1196910A/fr
Priority to AU78772/81A priority patent/AU549260B2/en
Priority to JP56207284A priority patent/JPS57163399A/ja
Priority to IE3077/81A priority patent/IE52462B1/en
Publication of FR2496669A1 publication Critical patent/FR2496669A1/fr
Priority to ES516143A priority patent/ES8307837A1/es
Application granted granted Critical
Publication of FR2496669B1 publication Critical patent/FR2496669B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
FR8027272A 1980-12-23 1980-12-23 Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments Granted FR2496669A1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR8027272A FR2496669A1 (fr) 1980-12-23 1980-12-23 Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments
IL64503A IL64503A0 (en) 1980-12-23 1981-12-10 7-substituted steroids,their preparation and compositions containing them
ES507890A ES8401989A1 (es) 1980-12-23 1981-12-11 Un procedimiento de preparacion de nuevos derivados esteroides 3-ceto a2 o a1,4 sustituidos en posicion 7 .
ZA818673A ZA818673B (en) 1980-12-23 1981-12-14 Derivatives of steroids 3-keto delta 4 or delta 1,4 substituted in position 7,their preparation,their application as medicaments and the compositions containing them
AT81401994T ATE10004T1 (de) 1980-12-23 1981-12-14 In stellung 7 substituierte 3-keto-delta-4oder -delta-1,4-steroidderivate, ihre herstellung, ihre verwendung als arzneimittel und pharmazeutische zusammensetzungen, die sie enthalten.
DE8181401994T DE3166872D1 (en) 1980-12-23 1981-12-14 3-keto-delta-4 or delta-1,4 steroid derivatives substituted at position 7, their preparation, their utilization as pharmaceutical compositions, and compositions containing them
EP81401994A EP0055170B1 (fr) 1980-12-23 1981-12-14 Nouveaux dérivés stéroides 3-céto delta 4 ou delta 1-4 substitués en position 7, leur préparation, leur application comme médicaments et les compositions les renfermant
MX761281A MX155082A (es) 1980-12-23 1981-12-16 Procedimiento para la obtencion de derivados substituidos en la posicion 7 de acidos pregna-1,4-dienoicos
SU813366202A SU1301317A3 (ru) 1980-12-23 1981-12-17 Способ получени 3-кето- @ -стероидов,замещенных в положении 7
US06/332,842 US4396614A (en) 1980-12-23 1981-12-21 Novel steroids
FI814109A FI77463C (fi) 1980-12-23 1981-12-21 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara i position 7 substituerade 3-keto- 4 eller 1,4-derivat.
GR66857A GR77629B ( ) 1980-12-23 1981-12-21
HU813907A HU184974B (en) 1980-12-23 1981-12-22 Process for producing 3-keto-steroide derivatives
PT74184A PT74184B (fr) 1980-12-23 1981-12-22 Procede de preparation de nouveaux derives steroides 3-ceto delta 4 ou delta 1, 4 substitues en position 7
KR1019810005067A KR870001937B1 (ko) 1980-12-23 1981-12-22 7위에 치환된 3-케토 △₄또는 △₁,₄스테로이드 유도체의 제조방법
DK569281A DK569281A (da) 1980-12-23 1981-12-22 Fremgangsmaade til fremstilling af 7-substituerede 3-keto-delta4- eller-delta 1,4-steroider
CA000392942A CA1196910A (fr) 1980-12-23 1981-12-22 Procede de preparation de nouveaux derives steroides 3-ceto .delta.4 ou .delta.1-4 substitues en position 7
AU78772/81A AU549260B2 (en) 1980-12-23 1981-12-22 Derivatives of steroids 3-keto delta 4 or delta 1, 4, substituted in position
JP56207284A JPS57163399A (en) 1980-12-23 1981-12-23 Novel derivative of 7 position-substituted 3-keto-delta 4 or delta 1,4-steroid, manufacture, application as drug and composition
IE3077/81A IE52462B1 (en) 1980-12-23 1981-12-23 3-keto delta4 or delta1,4 steroids substituted in position 7,their preparation,their use as medicaments and compositions containing them
ES516143A ES8307837A1 (es) 1980-12-23 1982-10-01 Un procedimiento de preparacion de nuevos derivados esteroides 3-cetodelta2 0delta1,4 sustituidos en posicion 7.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8027272A FR2496669A1 (fr) 1980-12-23 1980-12-23 Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
FR2496669A1 true FR2496669A1 (fr) 1982-06-25
FR2496669B1 FR2496669B1 ( ) 1983-10-28

Family

ID=9249374

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8027272A Granted FR2496669A1 (fr) 1980-12-23 1980-12-23 Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments

Country Status (19)

Country Link
US (1) US4396614A ( )
EP (1) EP0055170B1 ( )
JP (1) JPS57163399A ( )
KR (1) KR870001937B1 ( )
AT (1) ATE10004T1 ( )
AU (1) AU549260B2 ( )
CA (1) CA1196910A ( )
DE (1) DE3166872D1 ( )
DK (1) DK569281A ( )
ES (2) ES8401989A1 ( )
FI (1) FI77463C ( )
FR (1) FR2496669A1 ( )
GR (1) GR77629B ( )
HU (1) HU184974B ( )
IE (1) IE52462B1 ( )
IL (1) IL64503A0 ( )
PT (1) PT74184B ( )
SU (1) SU1301317A3 ( )
ZA (1) ZA818673B ( )

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501695A (en) * 1983-05-16 1985-02-26 The Upjohn Company Spironalactone process
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US5276023A (en) * 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters
WO2008137038A1 (en) 2007-05-03 2008-11-13 Yale University Locally active 'soft' antiandrogens

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2150852A1 ( ) * 1971-08-25 1973-04-13 Searle & Co
FR2255914A1 ( ) * 1973-12-26 1975-07-25 Searle & Co
EP0018245A1 (fr) * 1979-03-22 1980-10-29 Roussel-Uclaf Nouveaux dérivés stéroides 7-alkylés, leur procédé de préparation, leur application comme médicament et les compositions pharmaceutiques les renfermant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3053840A (en) * 1960-06-23 1962-09-11 Searle & Co 11-oxygenated polydehydro 17-carboxyethyl-9-halo-17-hydroxyandrostan-3-one lactones

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2150852A1 ( ) * 1971-08-25 1973-04-13 Searle & Co
FR2255914A1 ( ) * 1973-12-26 1975-07-25 Searle & Co
EP0018245A1 (fr) * 1979-03-22 1980-10-29 Roussel-Uclaf Nouveaux dérivés stéroides 7-alkylés, leur procédé de préparation, leur application comme médicament et les compositions pharmaceutiques les renfermant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/61 *

Also Published As

Publication number Publication date
FI77463B (fi) 1988-11-30
EP0055170A1 (fr) 1982-06-30
FI814109L (fi) 1982-06-24
AU549260B2 (en) 1986-01-23
FI77463C (fi) 1989-03-10
KR870001937B1 (ko) 1987-10-22
CA1196910A (fr) 1985-11-19
ATE10004T1 (de) 1984-11-15
AU7877281A (en) 1982-07-01
US4396614A (en) 1983-08-02
DK569281A (da) 1982-06-24
SU1301317A3 (ru) 1987-03-30
ES516143A0 (es) 1983-08-01
FR2496669B1 ( ) 1983-10-28
PT74184A (fr) 1982-01-01
IL64503A0 (en) 1982-03-31
IE52462B1 (en) 1987-11-11
GR77629B ( ) 1984-09-25
ES507890A0 (es) 1984-01-01
ES8401989A1 (es) 1984-01-01
PT74184B (fr) 1984-01-05
KR830007713A (ko) 1983-11-04
ZA818673B (en) 1982-10-27
JPS57163399A (en) 1982-10-07
DE3166872D1 (en) 1984-11-29
JPH0133115B2 ( ) 1989-07-11
EP0055170B1 (fr) 1984-10-24
ES8307837A1 (es) 1983-08-01
IE813077L (en) 1982-06-23
HU184974B (en) 1984-11-28

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