JPS57163399A - Novel derivative of 7 position-substituted 3-keto-delta 4 or delta 1,4-steroid, manufacture, application as drug and composition - Google Patents

Novel derivative of 7 position-substituted 3-keto-delta 4 or delta 1,4-steroid, manufacture, application as drug and composition

Info

Publication number
JPS57163399A
JPS57163399A JP56207284A JP20728481A JPS57163399A JP S57163399 A JPS57163399 A JP S57163399A JP 56207284 A JP56207284 A JP 56207284A JP 20728481 A JP20728481 A JP 20728481A JP S57163399 A JPS57163399 A JP S57163399A
Authority
JP
Japan
Prior art keywords
group
delta
free
carbon atoms
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56207284A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0133115B2 (
Inventor
Nedoretsuku Riyushian
Toreri Besuperuto
Fuiribeeru Danieru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of JPS57163399A publication Critical patent/JPS57163399A/ja
Publication of JPH0133115B2 publication Critical patent/JPH0133115B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
JP56207284A 1980-12-23 1981-12-23 Novel derivative of 7 position-substituted 3-keto-delta 4 or delta 1,4-steroid, manufacture, application as drug and composition Granted JPS57163399A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8027272A FR2496669A1 (fr) 1980-12-23 1980-12-23 Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
JPS57163399A true JPS57163399A (en) 1982-10-07
JPH0133115B2 JPH0133115B2 ( ) 1989-07-11

Family

ID=9249374

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56207284A Granted JPS57163399A (en) 1980-12-23 1981-12-23 Novel derivative of 7 position-substituted 3-keto-delta 4 or delta 1,4-steroid, manufacture, application as drug and composition

Country Status (19)

Country Link
US (1) US4396614A ( )
EP (1) EP0055170B1 ( )
JP (1) JPS57163399A ( )
KR (1) KR870001937B1 ( )
AT (1) ATE10004T1 ( )
AU (1) AU549260B2 ( )
CA (1) CA1196910A ( )
DE (1) DE3166872D1 ( )
DK (1) DK569281A ( )
ES (2) ES8401989A1 ( )
FI (1) FI77463C ( )
FR (1) FR2496669A1 ( )
GR (1) GR77629B ( )
HU (1) HU184974B ( )
IE (1) IE52462B1 ( )
IL (1) IL64503A0 ( )
PT (1) PT74184B ( )
SU (1) SU1301317A3 ( )
ZA (1) ZA818673B ( )

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010527380A (ja) * 2007-05-03 2010-08-12 エール ユニヴァーシティ 局所活性「ソフト」抗アンドロゲン剤

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501695A (en) * 1983-05-16 1985-02-26 The Upjohn Company Spironalactone process
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US5276023A (en) * 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5096560A ( ) * 1973-12-26 1975-07-31
JPS55129300A (en) * 1979-03-22 1980-10-06 Roussel Uclaf Novel 77alkylated steroid derivatives*their manufacture*their use as drug and pharmaceutic composition containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3053840A (en) * 1960-06-23 1962-09-11 Searle & Co 11-oxygenated polydehydro 17-carboxyethyl-9-halo-17-hydroxyandrostan-3-one lactones
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5096560A ( ) * 1973-12-26 1975-07-31
JPS55129300A (en) * 1979-03-22 1980-10-06 Roussel Uclaf Novel 77alkylated steroid derivatives*their manufacture*their use as drug and pharmaceutic composition containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010527380A (ja) * 2007-05-03 2010-08-12 エール ユニヴァーシティ 局所活性「ソフト」抗アンドロゲン剤
US8552061B2 (en) 2007-05-03 2013-10-08 Yale University Locally active “soft” antiandrogens

Also Published As

Publication number Publication date
FR2496669A1 (fr) 1982-06-25
FI77463B (fi) 1988-11-30
EP0055170A1 (fr) 1982-06-30
FI814109L (fi) 1982-06-24
AU549260B2 (en) 1986-01-23
FI77463C (fi) 1989-03-10
KR870001937B1 (ko) 1987-10-22
CA1196910A (fr) 1985-11-19
ATE10004T1 (de) 1984-11-15
AU7877281A (en) 1982-07-01
US4396614A (en) 1983-08-02
DK569281A (da) 1982-06-24
SU1301317A3 (ru) 1987-03-30
ES516143A0 (es) 1983-08-01
FR2496669B1 ( ) 1983-10-28
PT74184A (fr) 1982-01-01
IL64503A0 (en) 1982-03-31
IE52462B1 (en) 1987-11-11
GR77629B ( ) 1984-09-25
ES507890A0 (es) 1984-01-01
ES8401989A1 (es) 1984-01-01
PT74184B (fr) 1984-01-05
KR830007713A (ko) 1983-11-04
ZA818673B (en) 1982-10-27
DE3166872D1 (en) 1984-11-29
JPH0133115B2 ( ) 1989-07-11
EP0055170B1 (fr) 1984-10-24
ES8307837A1 (es) 1983-08-01
IE813077L (en) 1982-06-23
HU184974B (en) 1984-11-28

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