GB2007661A - Monoalkylaniline derivatives - Google Patents

Monoalkylaniline derivatives

Info

Publication number
GB2007661A
GB2007661A GB7837545A GB7837545A GB2007661A GB 2007661 A GB2007661 A GB 2007661A GB 7837545 A GB7837545 A GB 7837545A GB 7837545 A GB7837545 A GB 7837545A GB 2007661 A GB2007661 A GB 2007661A
Authority
GB
United Kingdom
Prior art keywords
monoalkylaniline
derivatives
formula
monoalkylanilines
atheroscherotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7837545A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/836,948 external-priority patent/US4198522A/en
Priority claimed from US05/836,949 external-priority patent/US4136256A/en
Priority claimed from US05/836,946 external-priority patent/US4117158A/en
Priority claimed from US05/836,947 external-priority patent/US4273785A/en
Priority claimed from US05/860,915 external-priority patent/US4154756A/en
Priority claimed from US05/861,736 external-priority patent/US4196208A/en
Priority claimed from US05/874,431 external-priority patent/US4348399A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB2007661A publication Critical patent/GB2007661A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

There are provided novel monoalkylanilines which have properties indicating utility as hypolipidemic and anti- atheroscherotic agents. The compounds have the formula: <IMAGE> wherein R1 is a straight chain or branched alkyl group of the formula CnH2n+1 wherein n is an integer from 8 to 19 inclusive; R2 is hydrogen or a group convertable in vivo thereinto and A is a specified substituent including amidated or esterified carboxy.
GB7837545A 1977-09-27 1978-09-20 Monoalkylaniline derivatives Withdrawn GB2007661A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US05/836,948 US4198522A (en) 1977-09-27 1977-09-27 4-(Monoalkylamino)phenyl carbinols and ester derivatives
US05/836,949 US4136256A (en) 1977-09-27 1977-09-27 4-(monoalkylamino)benzoic acid imidates
US05/836,946 US4117158A (en) 1977-09-27 1977-09-27 4-(monoalkylamino)benzonitriles useful as anti-atherosclerotic agents
US05/836,947 US4273785A (en) 1977-09-27 1977-09-27 Benzaldehydes, alkanophenones, and benzophenones and derivatives thereof containing a 4-monoalkylamino group
US05/860,915 US4154756A (en) 1977-12-15 1977-12-15 2-Substituted-4'-(monoalkylamino)-acetophenones
US05/861,736 US4196208A (en) 1977-12-19 1977-12-19 Certain pyridyl esters of 4-(monoalkylamino) benzoic hydroxyalkanoic acids
US05/874,431 US4348399A (en) 1978-02-02 1978-02-02 Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives

Publications (1)

Publication Number Publication Date
GB2007661A true GB2007661A (en) 1979-05-23

Family

ID=27569925

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7837545A Withdrawn GB2007661A (en) 1977-09-27 1978-09-20 Monoalkylaniline derivatives

Country Status (7)

Country Link
DD (1) DD138975A5 (en)
DE (1) DE2841707A1 (en)
DK (1) DK424378A (en)
FI (1) FI782932A (en)
FR (1) FR2408561A1 (en)
GB (1) GB2007661A (en)
NL (1) NL7809759A (en)

Also Published As

Publication number Publication date
DE2841707A1 (en) 1979-04-05
FI782932A (en) 1979-03-28
DD138975A5 (en) 1979-12-05
NL7809759A (en) 1979-03-29
FR2408561A1 (en) 1979-06-08
DK424378A (en) 1979-03-27

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)