FR2492382B1 - - Google Patents

Info

Publication number
FR2492382B1
FR2492382B1 FR8022537A FR8022537A FR2492382B1 FR 2492382 B1 FR2492382 B1 FR 2492382B1 FR 8022537 A FR8022537 A FR 8022537A FR 8022537 A FR8022537 A FR 8022537A FR 2492382 B1 FR2492382 B1 FR 2492382B1
Authority
FR
France
Prior art keywords
methylthiophenyl
imidazo
pyridine
methyl
dimethyl acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8022537A
Other languages
English (en)
French (fr)
Other versions
FR2492382A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9247171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2492382(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR8022537A priority Critical patent/FR2492382A1/fr
Priority to EP81401606A priority patent/EP0050563B1/fr
Priority to AT81401606T priority patent/ATE7393T1/de
Priority to DE8181401606T priority patent/DE3163524D1/de
Priority to LU88228C priority patent/LU88228I2/xx
Priority to MX81101627U priority patent/MX6463E/es
Priority to IL64091A priority patent/IL64091A/xx
Priority to ES506412A priority patent/ES8207537A1/es
Priority to FI813288A priority patent/FI71143C/fi
Priority to ZA817297A priority patent/ZA817297B/xx
Priority to AU76687/81A priority patent/AU544345B2/en
Priority to JP56169392A priority patent/JPS5798283A/ja
Priority to PT73863A priority patent/PT73863B/pt
Priority to IE2470/81A priority patent/IE51686B1/en
Priority to GR66315A priority patent/GR74701B/el
Priority to NO813551A priority patent/NO155664C/no
Priority to CA000388385A priority patent/CA1157470A/en
Priority to DK465181A priority patent/DK154429C/da
Priority to US06/313,601 priority patent/US4382938A/en
Priority to NZ198722A priority patent/NZ198722A/xx
Priority to OA57664A priority patent/OA07076A/xx
Publication of FR2492382A1 publication Critical patent/FR2492382A1/fr
Priority to US06/465,605 priority patent/US4460592A/en
Publication of FR2492382B1 publication Critical patent/FR2492382B1/fr
Application granted granted Critical
Priority to NL930044C priority patent/NL930044I2/nl
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR8022537A 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique Granted FR2492382A1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR8022537A FR2492382A1 (fr) 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
EP81401606A EP0050563B1 (fr) 1980-10-22 1981-10-15 Dérivés d'imidazo(1,2-a)pyridine, leur préparation et leur application en thérapeutique
AT81401606T ATE7393T1 (de) 1980-10-22 1981-10-15 Imidazo(1,2-a)pyridinderivate, verfahren zu ihrer herstellung und ihre therapeutische anwendung.
DE8181401606T DE3163524D1 (en) 1980-10-22 1981-10-15 Imidazo(1,2-a)pyridine derivatives, process for their preparation and their therapeutical use
LU88228C LU88228I2 (https=) 1980-10-22 1981-10-15
MX81101627U MX6463E (es) 1980-10-22 1981-10-19 Procedimiento para preparar derivados de imidazo(1,2-a)-piridina
PT73863A PT73863B (fr) 1980-10-22 1981-10-21 Procede de preparation de derives d'imidazo^1,2-a[pyridine applicables en therapeutique
DK465181A DK154429C (da) 1980-10-22 1981-10-21 Analogifremgangsmaade til fremstilling af imidazooe1,2-aaapyridinderivater eller syreadditionssalte heraf
FI813288A FI71143C (fi) 1980-10-22 1981-10-21 Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazo/1,2-a/pyridiner
ZA817297A ZA817297B (en) 1980-10-22 1981-10-21 Imidazo(1,2-a)pyridine derivatives useful in therapy and their preparation
AU76687/81A AU544345B2 (en) 1980-10-22 1981-10-21 Imidazo(1,2-a)pyridine derivatives
JP56169392A JPS5798283A (en) 1980-10-22 1981-10-21 Imidazopyridine derivative
IL64091A IL64091A (en) 1980-10-22 1981-10-21 Arylimidazo(1,2-a)pyridine acetamide derivatives,their preparation and pharmaceutical compositions containing them
IE2470/81A IE51686B1 (en) 1980-10-22 1981-10-21 Imidazo(1,2-a)pyridine derivatives useful in therapy and their preparation
GR66315A GR74701B (https=) 1980-10-22 1981-10-21
NO813551A NO155664C (no) 1980-10-22 1981-10-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo(1,2-a)-pyridiner.
CA000388385A CA1157470A (en) 1980-10-22 1981-10-21 Imidazo[1,2,a]pyridine derivatives useful in therapy and their preparations
ES506412A ES8207537A1 (es) 1980-10-22 1981-10-21 Procedimiento de preparacion de imidazo (1,2-a)piridinas
US06/313,601 US4382938A (en) 1980-10-22 1981-10-21 Imidazo[1,2-a] pyridine derivatives and their application as pharmaceuticals
NZ198722A NZ198722A (en) 1980-10-22 1981-10-21 N-substituted-2-(phenyl or naphthyl)imidazo(1,2-a)-pyrid-3-ylacetamides
OA57664A OA07076A (fr) 1980-10-22 1982-04-21 Dérivés d'imidazo [1,2-a] pyridine et leur application en thérapeutique.
US06/465,605 US4460592A (en) 1980-10-22 1983-02-10 6-Methyl-2-(4-methylthiophenyl)-imidazo[1,2-a]-pyridine-3-N,N-dimethylacetamide
NL930044C NL930044I2 (nl) 1980-10-22 1993-05-28 ImidazoÄ1,2-aÜ pyridinederivaten, de bereiding hiervan en de therapeutische toepassing.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8022537A FR2492382A1 (fr) 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2492382A1 FR2492382A1 (fr) 1982-04-23
FR2492382B1 true FR2492382B1 (https=) 1983-07-29

Family

ID=9247171

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8022537A Granted FR2492382A1 (fr) 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Country Status (22)

Country Link
US (2) US4382938A (https=)
EP (1) EP0050563B1 (https=)
JP (1) JPS5798283A (https=)
AT (1) ATE7393T1 (https=)
AU (1) AU544345B2 (https=)
CA (1) CA1157470A (https=)
DE (1) DE3163524D1 (https=)
DK (1) DK154429C (https=)
ES (1) ES8207537A1 (https=)
FI (1) FI71143C (https=)
FR (1) FR2492382A1 (https=)
GR (1) GR74701B (https=)
IE (1) IE51686B1 (https=)
IL (1) IL64091A (https=)
LU (1) LU88228I2 (https=)
MX (1) MX6463E (https=)
NL (1) NL930044I2 (https=)
NO (1) NO155664C (https=)
NZ (1) NZ198722A (https=)
OA (1) OA07076A (https=)
PT (1) PT73863B (https=)
ZA (1) ZA817297B (https=)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2568879B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Imidazo(1,2-a)quinolines, leur preparation et leur application en therapeutique
FR2581646B1 (fr) * 1985-05-07 1987-09-18 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
FR2593179B1 (fr) * 1986-01-22 1988-04-01 Synthelabo Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique
ATE62687T1 (de) * 1986-01-22 1991-05-15 Synthelabo Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung.
FR2593817B1 (fr) * 1986-01-31 1988-04-15 Synthelabo Derives de tetrahydro-5,6,7,8 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
FR2599368B1 (fr) * 1986-06-02 1988-08-05 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
FR2606411B1 (fr) * 1986-11-07 1989-04-07 Synthelabo Imidazopyridine-acetamides, leur preparation et leur application en therapeutique
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
FR2612927B1 (fr) * 1987-03-27 1989-06-09 Synthelabo Derives d'imidazopyridines, leur preparation et leur application en therapeutique
EP0289371B1 (fr) * 1987-03-27 1991-09-25 Synthelabo Dérivés d'imidazopyridines, leur préparation et leur application en thérapeutique
FR2612928B1 (fr) * 1987-03-27 1989-06-16 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
US5032595A (en) * 1989-11-24 1991-07-16 Fidia-Georgetown Institute For The Neurosciences Method of stimulating steroidogenesis with alpidem
EP0809642A1 (en) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
EP1005863A1 (en) * 1998-12-04 2000-06-07 Synthelabo Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof
PT1038875E (pt) * 1999-03-25 2003-10-31 Synthon Bv Derivados de imidazopiridina e processo para os preparar
ATE297924T1 (de) * 1999-03-25 2005-07-15 Synthon Bv Zolpidem salze
US6333345B1 (en) 1999-05-14 2001-12-25 Sepracor, Inc. Methods of using and compositions comprising N-desmethylzolpidem
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
AU5066101A (en) * 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
CZ20023775A3 (cs) * 2000-04-24 2003-10-15 Teva Pharmaceutical Industries Ltd. Zolpidem hemitartrát
EP1475093B1 (en) 2000-04-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Micronized Zolpidem hemitartrate
AU2001264932A1 (en) * 2000-05-26 2001-12-11 Neurogen Corporation Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands
AU2001270297A1 (en) 2000-06-30 2002-01-14 Neurogen Corporation 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
IT1318624B1 (it) 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
WO2002014306A1 (en) * 2000-08-17 2002-02-21 Cilag Ag Process for the preparation of imidazopyridines
AU2001284322A1 (en) * 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE10117183A1 (de) * 2001-04-05 2002-10-10 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
KR100433502B1 (ko) * 2001-10-10 2004-06-07 철 양 확장부가 형성된 종이컵
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
EP1575952B1 (en) * 2002-12-18 2009-02-18 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
US20040204443A1 (en) * 2003-01-27 2004-10-14 Arthur Zaks Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives
US20040241100A1 (en) * 2003-03-17 2004-12-02 Fabre Kramer Pharmaceutical, Inc. Nasally administrable compositions of zolpidem and methods of use
WO2005010002A1 (en) * 2003-07-31 2005-02-03 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
JP2007509960A (ja) * 2003-10-28 2007-04-19 セプラコア インコーポレーテッド イミダゾ［１，２−ａ］ピリジン抗不安薬
US20050176680A1 (en) 2003-12-11 2005-08-11 Sepracor, Inc. Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
WO2005079851A2 (en) 2004-02-18 2005-09-01 Sepracor, Inc. Dopamine-agonist combination therapy with sedatives for improving sleep quality
WO2006008636A2 (en) * 2004-07-16 2006-01-26 Ranbaxy Laboratories Limited Processes for the preparation of zolpidem and its hemitartrate
US20060084806A1 (en) * 2004-07-21 2006-04-20 Ramasubramanian Sridharan Processes for the preparation of imidazo[1,2-a] pyridine derivatives
FR2874611B1 (fr) * 2004-08-31 2006-11-17 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1883408A4 (en) * 2005-05-25 2009-11-11 Transcept Pharmaceuticals Inc SOLID COMPOSITIONS AND METHODS FOR TREATMENT OF INSOMNIA IN THE NIGHT
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20070020333A1 (en) * 2005-07-20 2007-01-25 Chin-Chih Chiang Controlled release of hypnotic agents
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2006322314A1 (en) 2005-11-18 2007-06-14 Synthon B.V. Zolpidem tablets
EP1803722A1 (en) 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
US8309104B2 (en) * 2006-03-02 2012-11-13 Watson Pharmaceuticals, Inc. Oral controlled release formulation for sedative and hypnotic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007256893A1 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
CN101528226B (zh) * 2006-08-24 2012-01-11 澳大利亚核科学技术组织 靶向外周苯二氮卓受体的氟化配体
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
US20090076066A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched zolpidem
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
US20090169618A1 (en) * 2007-12-26 2009-07-02 Limor Ari-Pardo Zolpidem pharmaceutical compositions
CA2732969A1 (en) * 2008-08-19 2010-02-25 The University Of Sydney Novel compounds and their uses in diagnosis
US10478438B2 (en) 2008-10-16 2019-11-19 David Reed Helton Treatment of organophosphate exposure with ocinaplon
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010122576A1 (en) 2009-04-20 2010-10-28 Matrix Laboratories Ltd Improved process for the preparation of 6-methyl-2-[4-methyl phenyl] imidazo [1, 2-a] pyridine-3-n, n-dimethyl acetamide.
JP5433508B2 (ja) * 2009-06-25 2014-03-05 高田製薬株式会社 ゾルピデム酒石酸塩含有内用液剤
CN102234275B (zh) * 2010-04-27 2015-12-16 溧阳合誉药物科技有限公司 治疗失眠的氘代咪唑并[1,2-a]吡啶衍生物、制备方法及其应用
US8741888B2 (en) 2010-11-09 2014-06-03 Carl A. Forest Sleep aid composition and method
IN2013MU02428A (https=) * 2013-07-22 2015-06-19 3A Chemie Private Ltd
US10202376B2 (en) 2014-12-24 2019-02-12 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP3468545A4 (en) 2016-06-08 2020-07-22 President and Fellows of Harvard College METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME AND FRAGILE X SYNDROME
US10807987B2 (en) * 2018-03-28 2020-10-20 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CA3099751A1 (en) 2018-05-22 2019-11-28 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
EP3801512A4 (en) * 2018-05-29 2022-01-19 President and Fellows of Harvard College COMPOSITIONS AND METHODS TO REDUCE TACTILE DYSFUNCTION, ANXIETY AND SOCIAL DISABILITIES
WO2020198275A1 (en) 2019-03-25 2020-10-01 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3336194A (en) * 1963-04-30 1967-08-15 Merck & Co Inc Indolyl acid amides
GB1076089A (en) * 1965-11-09 1967-07-19 Selvi & C Lab Bioterapico New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof

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JPS5798283A (en) 1982-06-18
NL930044I1 (nl) 1993-08-02
DK154429C (da) 1989-04-17
IL64091A (en) 1984-12-31
MX6463E (es) 1985-06-06
FI71143B (fi) 1986-08-14
PT73863A (fr) 1981-11-01
OA07076A (fr) 1984-01-31
JPS637545B2 (https=) 1988-02-17
ATE7393T1 (de) 1984-05-15
PT73863B (fr) 1983-11-07
FR2492382A1 (fr) 1982-04-23
NL930044I2 (nl) 1993-09-16
US4382938A (en) 1983-05-10
IE812470L (en) 1982-04-22
GR74701B (https=) 1984-07-04
LU88228I2 (https=) 1994-02-03
EP0050563B1 (fr) 1984-05-09
EP0050563A1 (fr) 1982-04-28
DK154429B (da) 1988-11-14
AU544345B2 (en) 1985-05-23
NZ198722A (en) 1984-10-19
DE3163524D1 (en) 1984-06-14
NO813551L (no) 1982-04-23
DK465181A (da) 1982-04-23
AU7668781A (en) 1983-04-28
IL64091A0 (en) 1982-01-31
NO155664B (no) 1987-01-26
ES506412A0 (es) 1982-09-16
US4460592A (en) 1984-07-17
FI71143C (fi) 1986-11-24
ES8207537A1 (es) 1982-09-16
IE51686B1 (en) 1987-02-04
ZA817297B (en) 1982-09-29
CA1157470A (en) 1983-11-22
NO155664C (no) 1987-05-06
FI813288L (fi) 1982-04-23

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