FR2476124A1 - Procede de culture de cellules, unite de culture de cellules animales flottantes, et dispositif pour culture de cellules - Google Patents
Procede de culture de cellules, unite de culture de cellules animales flottantes, et dispositif pour culture de cellules Download PDFInfo
- Publication number
- FR2476124A1 FR2476124A1 FR8020019A FR8020019A FR2476124A1 FR 2476124 A1 FR2476124 A1 FR 2476124A1 FR 8020019 A FR8020019 A FR 8020019A FR 8020019 A FR8020019 A FR 8020019A FR 2476124 A1 FR2476124 A1 FR 2476124A1
- Authority
- FR
- France
- Prior art keywords
- cells
- cell culture
- floating
- hollow fibers
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004113 cell culture Methods 0.000 title abstract description 43
- 210000004102 animal cell Anatomy 0.000 title abstract description 22
- 210000004027 cell Anatomy 0.000 abstract description 107
- 239000012510 hollow fiber Substances 0.000 abstract description 61
- 239000001963 growth medium Substances 0.000 abstract description 39
- 210000004881 tumor cell Anatomy 0.000 abstract description 13
- 201000007270 liver cancer Diseases 0.000 abstract description 4
- 208000014018 liver neoplasm Diseases 0.000 abstract description 4
- 206010025323 Lymphomas Diseases 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 52
- 239000011148 porous material Substances 0.000 description 22
- 230000008569 process Effects 0.000 description 19
- 229920005573 silicon-containing polymer Polymers 0.000 description 17
- 230000001954 sterilising effect Effects 0.000 description 14
- 238000004659 sterilization and disinfection Methods 0.000 description 14
- 230000035755 proliferation Effects 0.000 description 12
- 239000000463 material Substances 0.000 description 10
- 239000004417 polycarbonate Substances 0.000 description 10
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- 208000006274 Brain Stem Neoplasms Diseases 0.000 description 9
- 239000000835 fiber Substances 0.000 description 9
- 239000007789 gas Substances 0.000 description 9
- 210000004698 lymphocyte Anatomy 0.000 description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 7
- 238000012258 culturing Methods 0.000 description 7
- 239000010408 film Substances 0.000 description 7
- 229920002492 poly(sulfone) Polymers 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000005062 Polybutadiene Substances 0.000 description 6
- 238000012136 culture method Methods 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 229920002857 polybutadiene Polymers 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000004927 fusion Effects 0.000 description 5
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- 230000008901 benefit Effects 0.000 description 3
- 201000006491 bone marrow cancer Diseases 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
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- 230000001413 cellular effect Effects 0.000 description 2
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- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920002239 polyacrylonitrile Polymers 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 125000001174 sulfone group Chemical group 0.000 description 2
- 238000004114 suspension culture Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102100031680 Beta-catenin-interacting protein 1 Human genes 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000993469 Homo sapiens Beta-catenin-interacting protein 1 Proteins 0.000 description 1
- 241000575946 Ione Species 0.000 description 1
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000007613 slurry method Methods 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
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- 210000004989 spleen cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
Landscapes
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11883379A JPS5642584A (en) | 1979-09-18 | 1979-09-18 | Cell cultivation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2476124A1 true FR2476124A1 (fr) | 1981-08-21 |
| FR2476124B1 FR2476124B1 (cg-RX-API-DMAC10.html) | 1983-05-27 |
Family
ID=14746276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8020019A Granted FR2476124A1 (fr) | 1979-09-18 | 1980-09-17 | Procede de culture de cellules, unite de culture de cellules animales flottantes, et dispositif pour culture de cellules |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4391912A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5642584A (cg-RX-API-DMAC10.html) |
| DE (1) | DE3035118C2 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2476124A1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB2062006B (cg-RX-API-DMAC10.html) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2940446C2 (de) * | 1979-10-05 | 1982-07-08 | B. Braun Melsungen Ag, 3508 Melsungen | Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen |
| US4442206A (en) * | 1980-08-21 | 1984-04-10 | Stanford University | Method of using isotropic, porous-wall polymeric membrane, hollow-fibers for culture of microbes |
| US4440853A (en) * | 1980-08-21 | 1984-04-03 | Board Of Trustees Of The Leland Stanford Junior University | Microbiological methods using hollow fiber membrane reactor |
| CH651587A5 (de) * | 1980-11-18 | 1985-09-30 | Chemap Ag | Verfahren und vorrichtung zur submersen zuechtung von zellkulturen. |
| JPS5889179A (ja) * | 1981-11-24 | 1983-05-27 | Japan Synthetic Rubber Co Ltd | 細胞培養床 |
| EP0125303A4 (en) * | 1982-11-16 | 1985-03-06 | Univ California | RAPID PRODUCTION OF BIOLOGICALS BY FERMENTATION IN A DENSE-LINED MICROBIAL MEMBRANE REACTOR. |
| US4537860A (en) * | 1982-12-08 | 1985-08-27 | Monsanto Company | Static cell culture maintenance system |
| US4937187A (en) * | 1983-02-04 | 1990-06-26 | Brown University Research Foundation | Methods for separating malignant cells from clinical specimens |
| CA1221045A (en) * | 1983-02-04 | 1987-04-28 | Bjorn K. Lydersen | Cell culture apparatus and process using an immobilized cell composite |
| US4734372A (en) * | 1983-02-04 | 1988-03-29 | Brown University Research Foundation | Cell culturing methods and apparatus |
| DE3317550C2 (de) * | 1983-05-13 | 1985-08-22 | Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees | Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens |
| JPS6156075A (ja) * | 1984-08-28 | 1986-03-20 | Teijin Ltd | ヒト・ヒトハイブリド−マの培養方法 |
| US4804628A (en) * | 1984-10-09 | 1989-02-14 | Endotronics, Inc. | Hollow fiber cell culture device and method of operation |
| CA1275273C (en) * | 1984-10-09 | 1990-10-16 | Micheal L. Gruenberg | Hollow fiber cell culture device and method of operation |
| JPS62500356A (ja) * | 1984-10-09 | 1987-02-19 | エンドトロニツクス インコ−ポレ−テツド | 栄養素の潅流および生成物の濃度を改良した中空繊維培養装置および運転方法 |
| GB8508976D0 (en) * | 1985-04-04 | 1985-05-09 | Davies G A | Reactor unit |
| US4647539A (en) * | 1985-05-24 | 1987-03-03 | Endotronics, Inc. | Method and apparatus for growing cells in vitro |
| JPS61280270A (ja) * | 1985-06-03 | 1986-12-10 | Teijin Ltd | 細胞培養装置 |
| IL75554A (en) * | 1985-06-18 | 1993-01-14 | Yeda Res & Dev | Matrix for cell cultivation in vitro |
| EP0220650A3 (en) * | 1985-10-21 | 1988-08-24 | Endotronics Inc. | Method and device for culturing cells |
| US4720462A (en) * | 1985-11-05 | 1988-01-19 | Robert Rosenson | Culture system for the culture of solid tissue masses and method of using the same |
| US5286646A (en) * | 1985-11-25 | 1994-02-15 | Boehringer Mannheim Gmbh | Method for mammalian cell culture |
| US4897358A (en) * | 1985-12-02 | 1990-01-30 | Carrasco Jose I | Tissue storage system |
| DE3782736T2 (de) * | 1986-04-28 | 1993-06-09 | Endotronics Inc | Zuchtverfahren fuer leukocyten. |
| US4937194A (en) * | 1986-05-12 | 1990-06-26 | Baxter International Inc. | Method for metering nutrient media to cell culture containers |
| IL82746A (en) * | 1986-06-06 | 1994-10-07 | Genentech Inc | Process for producing biologically active tissue-type plasminogen activator |
| US4833083A (en) * | 1987-05-26 | 1989-05-23 | Sepragen Corporation | Packed bed bioreactor |
| WO1989000188A1 (en) * | 1987-06-30 | 1989-01-12 | Brunswick Corporation | Cell growth reactor with three compartments formed by hydrophobic and hydrophilic membranes |
| US5081035A (en) * | 1988-04-18 | 1992-01-14 | The University Of Michigan | Bioreactor system |
| US4973558A (en) * | 1988-04-28 | 1990-11-27 | Endotronics, Inc. | Method of culturing cells using highly gas saturated media |
| DE3818776C2 (de) * | 1988-06-02 | 1994-06-30 | Maerkl Herbert | Verfahren zur Kultivierung von Zellen in einem Fermenter und zur Durchführung des Verfahrens bestimmter Fermenter |
| US5416022A (en) * | 1988-08-10 | 1995-05-16 | Cellex Biosciences, Inc. | Cell culture apparatus |
| US5079168A (en) * | 1988-08-10 | 1992-01-07 | Endotronics, Inc. | Cell culture apparatus |
| US5139946A (en) * | 1988-11-02 | 1992-08-18 | Du Pont Merck Pharmaceutical Company | Dot matrix membrane cell expansion |
| US5068195A (en) * | 1988-11-02 | 1991-11-26 | Du Pont Merck Pharmaceutical Company | Dot matrix membrane cell expansion and maintenance vessel |
| FR2640638B1 (fr) * | 1988-12-20 | 1991-02-15 | Commissariat Energie Atomique | Bioreacteur et dispositif pour la culture de cellules animales |
| JPH02255079A (ja) * | 1989-03-29 | 1990-10-15 | Shimadzu Corp | 細胞培養装置 |
| US4937196A (en) * | 1989-08-18 | 1990-06-26 | Brunswick Corporation | Membrane bioreactor system |
| EP0491851A4 (en) * | 1989-09-14 | 1993-02-17 | Cellco, Inc. | Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy |
| US5112760A (en) * | 1990-06-05 | 1992-05-12 | Centocor, Incorporated | Mass transfer membrane for oxygenation of animal cell reactors |
| JPH0728722B2 (ja) * | 1990-06-29 | 1995-04-05 | 富士写真フイルム株式会社 | バイオリアクター装置 |
| US5330908A (en) * | 1992-12-23 | 1994-07-19 | The United States Of America As Represented By The Administrator, National Aeronautics And Space Administration | High density cell culture system |
| US5882918A (en) * | 1995-08-08 | 1999-03-16 | Genespan Corporation | Cell culture incubator |
| US7101837B1 (en) * | 1995-01-24 | 2006-09-05 | Martinex R & D Inc. | Recombinant human alpha-fetoprotein as a cell proliferative agent |
| US6660509B1 (en) | 1995-03-28 | 2003-12-09 | Kinetic Biosystems, Inc. | Methods and devices for remediation and fermentation |
| US6133019A (en) * | 1995-03-28 | 2000-10-17 | Kinetic Biosystems, Inc. | Centrifugal fermentation process |
| US20050266548A1 (en) * | 1995-03-28 | 2005-12-01 | Kbi Biopharma, Inc. | Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor |
| US5622819A (en) * | 1995-03-28 | 1997-04-22 | Kinetic Biosystems, Inc. | Centrifugal fermentation process |
| US6214617B1 (en) | 1995-03-28 | 2001-04-10 | Kinetic Biosystems, Inc. | Centrifugal fermentation process |
| US6916652B2 (en) * | 1995-03-28 | 2005-07-12 | Kinetic Biosystems, Inc. | Biocatalyst chamber encapsulation system for bioremediation and fermentation |
| US5945338A (en) * | 1995-06-26 | 1999-08-31 | Vivorx Pharmaceuticals | Method and apparatus for augmenting mass transfer in a rotating cell culture system |
| US5523228A (en) * | 1995-07-07 | 1996-06-04 | Hmri/Clmf | Hydrodynamic cell culture environment for three dimensional tissue growth |
| US20020182730A1 (en) * | 1995-07-26 | 2002-12-05 | Micheal L. Gruenberg | Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease |
| JP3673640B2 (ja) * | 1997-05-15 | 2005-07-20 | キヤノン株式会社 | 汚染媒体の浄化方法およびそれに用いる浄化装置 |
| US6001643A (en) * | 1997-08-04 | 1999-12-14 | C-Med Inc. | Controlled hydrodynamic cell culture environment for three dimensional tissue growth |
| US6001585A (en) * | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
| US6235196B1 (en) | 1998-04-23 | 2001-05-22 | Alliedsignal Inc. | Biological wastewater treatment system |
| US20050158856A1 (en) * | 1999-04-20 | 2005-07-21 | Edelson Richard L. | Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials |
| US6703217B2 (en) | 2000-01-31 | 2004-03-09 | Kinetic Biosystems, Inc. | Methods and devices for remediation and fermentation |
| US7270996B2 (en) * | 2000-10-02 | 2007-09-18 | Cannon Thomas F | Automated bioculture and bioculture experiments system |
| US20020146817A1 (en) * | 2000-10-02 | 2002-10-10 | Cannon Thomas F. | Automated bioculture and bioculture experiments system |
| FR2821947B1 (fr) * | 2001-03-12 | 2003-05-16 | Canon Kk | Procede et dispositif de validation de parametres definissant une image |
| US6566126B2 (en) | 2001-06-22 | 2003-05-20 | Fibercell Systems, Inc. | Apparatus and method for growing cells |
| US20030134415A1 (en) * | 2001-09-19 | 2003-07-17 | Gruenberg Micheal L. | Th1 cell adoptive immunotherapy |
| US20030134341A1 (en) * | 2001-09-19 | 2003-07-17 | Medcell Biologics, Llc. | Th1 cell adoptive immunotherapy |
| US6667172B2 (en) | 2001-09-19 | 2003-12-23 | The Cleveland Clinic Foundation | Cell and tissue culture modeling device and apparatus and method of using same |
| US20030175272A1 (en) * | 2002-03-07 | 2003-09-18 | Medcell Biologics, Inc. | Re-activated T-cells for adoptive immunotherapy |
| US20040029266A1 (en) * | 2002-08-09 | 2004-02-12 | Emilio Barbera-Guillem | Cell and tissue culture device |
| US6673598B1 (en) | 2002-10-29 | 2004-01-06 | Synthecon, Inc. | Disposable culture bag |
| US7514256B2 (en) * | 2005-02-11 | 2009-04-07 | Emilio Barbera-Guillem | Bioreactor for selectively controlling the molecular diffusion between fluids |
| US8603805B2 (en) | 2005-04-22 | 2013-12-10 | Hyclone Laboratories, Inc. | Gas spargers and related container systems |
| ZA200602094B (en) * | 2006-01-16 | 2007-11-28 | Reliance Life Sciences Pvt Ltd | Device for culturing and transporting cells |
| DE102006031871B4 (de) * | 2006-07-10 | 2008-10-23 | Gerlach, Jörg, Dr.med. | 3-D Petri-Schale zur Züchtung und Untersuchung von Zellen |
| CA2680130C (en) | 2007-03-05 | 2016-01-12 | Caridianbct, Inc. | Cell expansion system and methods of use |
| ES2665024T3 (es) * | 2007-03-05 | 2018-04-24 | Terumo Bct, Inc. | Métodos para controlar el movimiento celular en biorreactores de fibra hueca |
| DE102007020671A1 (de) * | 2007-05-01 | 2008-11-06 | Justus-Liebig-Universität Giessen | Verfahren und Vorrichtung zum kontaktfreien Materialwachstum in einer strömenden Lösung (FLow suspended solution growth (FSSG)) |
| CN101096639B (zh) * | 2007-05-16 | 2011-08-10 | 宁波 | 多组纤维管均匀分布的多功能中空纤维膜管生物反应器 |
| WO2009111022A1 (en) * | 2008-03-07 | 2009-09-11 | Corning Incorporated | Hydrophobically modified cellulose ether derivatives for cell culture and release |
| US8778669B2 (en) * | 2009-07-22 | 2014-07-15 | Corning Incorporated | Multilayer tissue culture vessel |
| JP2011103882A (ja) * | 2009-11-16 | 2011-06-02 | Shuhei Nakaji | 細胞培養装置、細胞培養方法および細胞培養用プログラム |
| US9057045B2 (en) * | 2009-12-29 | 2015-06-16 | Terumo Bct, Inc. | Method of loading and distributing cells in a bioreactor of a cell expansion system |
| EP2566951B1 (en) | 2010-05-05 | 2020-03-04 | Terumo BCT, Inc. | Method of reseeding adherent cells grown in a hollow fiber bioreactor system |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| US9376655B2 (en) | 2011-09-29 | 2016-06-28 | Life Technologies Corporation | Filter systems for separating microcarriers from cell culture solutions |
| CN104114266B (zh) | 2011-09-30 | 2016-12-14 | 生命科技股份有限公司 | 具有膜喷洒器的容器 |
| US9683207B2 (en) | 2012-05-01 | 2017-06-20 | FiberCell Production Solutions LLC | Method for growing cells in hollow fibers |
| JP6466841B2 (ja) | 2012-08-20 | 2019-02-06 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖システムのバイオリアクターにおける細胞の投入・分配方法 |
| US9005550B2 (en) | 2012-10-29 | 2015-04-14 | Corning Incorporated | Multi-layered cell culture vessel with manifold grips |
| EP3068866B1 (en) | 2013-11-16 | 2018-04-25 | Terumo BCT, Inc. | Expanding cells in a bioreactor |
| CN106232800B (zh) | 2014-03-25 | 2020-07-03 | 泰尔茂比司特公司 | 介质的被动替代 |
| US10077421B2 (en) | 2014-04-24 | 2018-09-18 | Terumo Bct, Inc. | Measuring flow rate |
| US9079690B1 (en) | 2014-06-26 | 2015-07-14 | Advanced Scientifics, Inc. | Freezer bag, storage system, and method of freezing |
| EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
| WO2016077277A1 (en) * | 2014-11-10 | 2016-05-19 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Modular microtube network for vascularized organ-on-a-chip models |
| EP3098304A1 (en) | 2015-05-28 | 2016-11-30 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Hybrid cell detachment-free cell expansion system for adherent cell culturing and related proceeding protocol |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US10279312B2 (en) * | 2016-03-06 | 2019-05-07 | Angelo Karavolos | Electronic component and material for sustainable removal of waste products and generation of consumables |
| EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US10589197B2 (en) | 2016-12-01 | 2020-03-17 | Life Technologies Corporation | Microcarrier filter bag assemblies and methods of use |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| WO2018184028A2 (en) | 2017-03-31 | 2018-10-04 | Terumo Bct, Inc. | Cell expansion |
| CN207760352U (zh) * | 2017-12-18 | 2018-08-24 | 上海白泽医疗器械有限公司 | 细胞培养模块、培养液模块、细胞培养芯片及细胞培养机箱 |
| AU2020369940A1 (en) | 2019-10-21 | 2022-05-26 | Flaskworks, Llc | Systems and methods for cell culturing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2184960A1 (cg-RX-API-DMAC10.html) * | 1972-05-18 | 1973-12-28 | Cellco | |
| FR2236004A1 (cg-RX-API-DMAC10.html) * | 1973-07-02 | 1975-01-31 | Monsanto Co |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3734851A (en) * | 1969-12-29 | 1973-05-22 | K Matsumura | Method and device for purifying blood |
| US3883393A (en) * | 1972-05-18 | 1975-05-13 | Us Health Education & Welfare | Cell culture on semi-permeable tubular membranes |
| US3911140A (en) * | 1973-07-02 | 1975-10-07 | Milk Marketing Board | Preparation of concentrated starter cultures |
| JPS5193786A (en) | 1975-02-15 | 1976-08-17 | Makurokagatano chukuseni | |
| JPS5198382A (ja) * | 1975-02-24 | 1976-08-30 | Saibobaiyoki | |
| US4201845A (en) * | 1976-04-12 | 1980-05-06 | Monsanto Company | Cell culture reactor |
| US4087327A (en) * | 1976-04-12 | 1978-05-02 | Monsanto Company | Mammalion cell culture process |
| US4242460A (en) * | 1978-12-26 | 1980-12-30 | Chick William L | Cell culture device |
-
1979
- 1979-09-18 JP JP11883379A patent/JPS5642584A/ja active Pending
-
1980
- 1980-09-17 FR FR8020019A patent/FR2476124A1/fr active Granted
- 1980-09-17 DE DE3035118A patent/DE3035118C2/de not_active Expired
- 1980-09-18 US US06/188,416 patent/US4391912A/en not_active Expired - Lifetime
- 1980-09-18 GB GB8030253A patent/GB2062006B/en not_active Expired
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2184960A1 (cg-RX-API-DMAC10.html) * | 1972-05-18 | 1973-12-28 | Cellco | |
| FR2236004A1 (cg-RX-API-DMAC10.html) * | 1973-07-02 | 1975-01-31 | Monsanto Co | |
| US3997396A (en) * | 1973-07-02 | 1976-12-14 | Monsanto Company | Method for the in vitro propagation and maintenance of cells |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/72 * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2062006A (en) | 1981-05-20 |
| DE3035118C2 (de) | 1982-09-23 |
| DE3035118A1 (de) | 1981-03-19 |
| JPS5642584A (en) | 1981-04-20 |
| GB2062006B (en) | 1983-08-24 |
| US4391912A (en) | 1983-07-05 |
| FR2476124B1 (cg-RX-API-DMAC10.html) | 1983-05-27 |
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