EP0491851A4 - Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy - Google Patents
Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapyInfo
- Publication number
- EP0491851A4 EP0491851A4 EP19900914826 EP90914826A EP0491851A4 EP 0491851 A4 EP0491851 A4 EP 0491851A4 EP 19900914826 EP19900914826 EP 19900914826 EP 90914826 A EP90914826 A EP 90914826A EP 0491851 A4 EP0491851 A4 EP 0491851A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- production
- lymphoid cells
- adoptive immunotherapy
- vitro expanded
- expanded lymphoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Sustainable Development (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40745689A | 1989-09-14 | 1989-09-14 | |
US407456 | 1989-09-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0491851A1 EP0491851A1 (en) | 1992-07-01 |
EP0491851A4 true EP0491851A4 (en) | 1993-02-17 |
Family
ID=23612175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19900914826 Withdrawn EP0491851A4 (en) | 1989-09-14 | 1990-09-11 | Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0491851A4 (en) |
JP (1) | JPH05502369A (en) |
AU (1) | AU652725B2 (en) |
CA (1) | CA2066645A1 (en) |
WO (1) | WO1991004317A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06500927A (en) * | 1990-12-13 | 1994-01-27 | アメリカ合衆国 | Sustained and continuous production of high titer recombinant viral vectors and transduced target cells for gene therapy |
IT1261180B (en) * | 1993-02-10 | 1996-05-09 | IN VITRO PROPAGATION METHOD OF TIL CELLS. | |
DK0879282T3 (en) | 1996-01-17 | 2003-10-20 | Imp College Innovations Ltd | Immunotherapy using cytotoxic T lymphocytes (CTL) |
DE10021627B4 (en) * | 2000-05-04 | 2009-11-19 | Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich | Method for producing a vascularized bioartificial tissue and associated experimental reactor |
EP1408106B1 (en) * | 2002-10-11 | 2007-02-14 | Sentoclone Therapeutics AB | Cancer immuno-therapy |
EP1479760A1 (en) * | 2003-05-19 | 2004-11-24 | ProBioGen AG | Artificial immune organ |
CN107750271B (en) * | 2015-05-13 | 2021-12-10 | 泰尔茂比司特公司 | Cell expansion |
WO2017040670A1 (en) * | 2015-09-01 | 2017-03-09 | Ifm Therapeutics, Inc | Immune cells having increased immunity or resistance to an immunosuppressive cytokine and use of the same |
EP3216861A1 (en) * | 2016-03-11 | 2017-09-13 | Fropharm GmbH | Immunoregulatory cells and methods for their production |
RU2755725C2 (en) * | 2016-09-12 | 2021-09-20 | Джуно Терапьютикс, Инк. | Assembly units of perfusion bioreactor bags |
CN109536444B (en) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | Separation induction method suitable for malignant solid tumor infiltrating T lymphocytes |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987006610A1 (en) * | 1986-04-28 | 1987-11-05 | Endotronics, Inc. | Method of culturing leukocytes |
WO1990014097A1 (en) * | 1989-05-15 | 1990-11-29 | E.I. Du Pont De Nemours And Company | Improved culture of human tumor-infiltrating lymphocytes by combining gas permeable bags and a primary culture container |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3883393A (en) * | 1972-05-18 | 1975-05-13 | Us Health Education & Welfare | Cell culture on semi-permeable tubular membranes |
JPS5642584A (en) * | 1979-09-18 | 1981-04-20 | Asahi Chem Ind Co Ltd | Cell cultivation method |
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
-
1990
- 1990-09-11 AU AU65008/90A patent/AU652725B2/en not_active Ceased
- 1990-09-11 EP EP19900914826 patent/EP0491851A4/en not_active Withdrawn
- 1990-09-11 WO PCT/US1990/005051 patent/WO1991004317A1/en not_active Application Discontinuation
- 1990-09-11 CA CA002066645A patent/CA2066645A1/en not_active Abandoned
- 1990-09-11 JP JP2513730A patent/JPH05502369A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987006610A1 (en) * | 1986-04-28 | 1987-11-05 | Endotronics, Inc. | Method of culturing leukocytes |
WO1990014097A1 (en) * | 1989-05-15 | 1990-11-29 | E.I. Du Pont De Nemours And Company | Improved culture of human tumor-infiltrating lymphocytes by combining gas permeable bags and a primary culture container |
Non-Patent Citations (3)
Title |
---|
JOURNAL OF IMMUNOLOGICAL METHODS vol. 127, no. 1, 1990, AMSTERDAM pages 29 - 37 KNAZEK R.A. ET AL 'Culture of human tumor infiltrating lymphocytes in hollow fiber bioreactors' * |
SCIENCE vol. 244, no. 4910, 16 June 1989, LANCASTER, PA US pages 1430 - 1433 CULLITON B.J. 'Fighting cancer with designer cells' * |
See also references of WO9104317A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU6500890A (en) | 1991-04-18 |
WO1991004317A1 (en) | 1991-04-04 |
EP0491851A1 (en) | 1992-07-01 |
AU652725B2 (en) | 1994-09-08 |
CA2066645A1 (en) | 1991-03-15 |
JPH05502369A (en) | 1993-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19920317 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19921230 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
17Q | First examination report despatched |
Effective date: 19940224 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19960109 |