FR2473044A1 - Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation - Google Patents

Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation Download PDF

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Publication number
FR2473044A1
FR2473044A1 FR8100206A FR8100206A FR2473044A1 FR 2473044 A1 FR2473044 A1 FR 2473044A1 FR 8100206 A FR8100206 A FR 8100206A FR 8100206 A FR8100206 A FR 8100206A FR 2473044 A1 FR2473044 A1 FR 2473044A1
Authority
FR
France
Prior art keywords
formula
methyl
preparation
group
thiol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8100206A
Other languages
English (en)
French (fr)
Other versions
FR2473044B1 (es
Inventor
John Bradshaw
John Watson Clitherow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2473044A1 publication Critical patent/FR2473044A1/fr
Application granted granted Critical
Publication of FR2473044B1 publication Critical patent/FR2473044B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8100206A 1980-01-08 1981-01-08 Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation Granted FR2473044A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8000581 1980-01-08
GB8000580 1980-01-08
GB8039336 1980-12-08

Publications (2)

Publication Number Publication Date
FR2473044A1 true FR2473044A1 (fr) 1981-07-10
FR2473044B1 FR2473044B1 (es) 1984-04-13

Family

ID=27260837

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8100206A Granted FR2473044A1 (fr) 1980-01-08 1981-01-08 Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation

Country Status (14)

Country Link
JP (1) JPH02167259A (es)
AR (1) AR225940A1 (es)
AT (1) AT376966B (es)
CH (1) CH650257A5 (es)
DE (1) DE3100364A1 (es)
DK (1) DK157865C (es)
ES (1) ES498389A0 (es)
FI (1) FI80450C (es)
FR (1) FR2473044A1 (es)
HU (1) HU182272B (es)
NL (1) NL8100068A (es)
PT (1) PT72320B (es)
SE (2) SE449747B (es)
YU (1) YU42372B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413373A1 (fr) * 1977-12-30 1979-07-27 Ricerca Chimica Sa Comp Di Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine
EP0005984A1 (en) * 1978-05-30 1979-12-12 Smith Kline & French Laboratories Limited Nitro compounds, processes for preparing them and compositions containing them
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
FR2482595A1 (fr) * 1980-05-13 1981-11-20 Ricerca Chimica Spa Comp Procede de preparation de n-(2-(((5-(dial-kylamino) - methyl-2-furanyl)-methyl)-thio)-ethyl)-n'-alkyl-2-nitro-1,1-ethenediamines et des intermediaires de synthese mis en oeuvre dans ce procede

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL56265A (en) 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
FR2413373A1 (fr) * 1977-12-30 1979-07-27 Ricerca Chimica Sa Comp Di Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine
EP0005984A1 (en) * 1978-05-30 1979-12-12 Smith Kline & French Laboratories Limited Nitro compounds, processes for preparing them and compositions containing them
FR2482595A1 (fr) * 1980-05-13 1981-11-20 Ricerca Chimica Spa Comp Procede de preparation de n-(2-(((5-(dial-kylamino) - methyl-2-furanyl)-methyl)-thio)-ethyl)-n'-alkyl-2-nitro-1,1-ethenediamines et des intermediaires de synthese mis en oeuvre dans ce procede

Also Published As

Publication number Publication date
SE8502780L (sv) 1985-06-05
DK157865B (da) 1990-02-26
YU2781A (en) 1983-06-30
SE449747B (sv) 1987-05-18
PT72320A (en) 1981-02-01
PT72320B (en) 1982-07-23
FI810039L (fi) 1981-07-09
FI80450C (fi) 1990-06-11
ES8200673A1 (es) 1981-11-16
AT376966B (de) 1985-01-25
FI80450B (fi) 1990-02-28
ES498389A0 (es) 1981-11-16
JPH02167259A (ja) 1990-06-27
CH650257A5 (fr) 1985-07-15
SE8100074L (sv) 1981-07-09
ATA3781A (de) 1984-06-15
FR2473044B1 (es) 1984-04-13
DK157865C (da) 1990-07-30
HU182272B (en) 1983-12-28
NL8100068A (nl) 1981-08-03
DE3100364C2 (es) 1989-12-28
SE8502780D0 (sv) 1985-06-05
DK7181A (da) 1981-07-09
JPH0346465B2 (es) 1991-07-16
AR225940A1 (es) 1982-05-14
YU42372B (en) 1988-08-31
SE460604B (sv) 1989-10-30
DE3100364A1 (de) 1981-11-19

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