FR2413373A1 - Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine - Google Patents

Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine

Info

Publication number
FR2413373A1
FR2413373A1 FR7836922A FR7836922A FR2413373A1 FR 2413373 A1 FR2413373 A1 FR 2413373A1 FR 7836922 A FR7836922 A FR 7836922A FR 7836922 A FR7836922 A FR 7836922A FR 2413373 A1 FR2413373 A1 FR 2413373A1
Authority
FR
France
Prior art keywords
bopi
mercaptomethylimidazoles
alkylation process
aziridine derivatives
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7836922A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ricerca Chimica SA Comp Di
Original Assignee
Ricerca Chimica SA Comp Di
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25707086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2413373(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH1634077A external-priority patent/CH631971A5/de
Application filed by Ricerca Chimica SA Comp Di filed Critical Ricerca Chimica SA Comp Di
Publication of FR2413373A1 publication Critical patent/FR2413373A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'INVENTION CONCERNE UN PROCEDE POUR LA PREPARATION DE N-CYANO-N-2-(4- OU 5-METHYL-1H-IMIDAZOLE-5 OU -4-YL)-METHYLTHIOETHYL-GUANIDINES DE FORMULES GENERALES: (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) DANS LESQUELLES R REPRESENTE UN GROUPE ALKYLE JUSQU'EN C. ON FAIT REAGIR DES 5(4)-METHYL-4(5)-MERCAPTOMETHYL-IMIDAZOLES DE FORMULES GENERALES: (CF DESSIN DANS BOPI) SOUS FORME DE BASE LIBRE OU D'UN SEL AVEC UN DERIVE D'AZIRIDINE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST TEL QUE DEFINI CI-DESSUS. LE PROCEDE EST PLUS ECONOMIQUE EN RAISON DE SON RENDEMENT ELEVE, DE L'ECONOMIE D'UNE ETAPE REACTIONNELLE ET DE L'UTILISATION DE PRODUITS DE DEPART PEU COUTEUX.
FR7836922A 1977-12-30 1978-12-29 Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine Pending FR2413373A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1634077A CH631971A5 (en) 1977-12-30 1977-12-30 Process for preparing imidazole derivatives
CH1069578 1978-10-16

Publications (1)

Publication Number Publication Date
FR2413373A1 true FR2413373A1 (fr) 1979-07-27

Family

ID=25707086

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7836922A Pending FR2413373A1 (fr) 1977-12-30 1978-12-29 Procede d'alkylation de 4(5)-mercaptomethylimidazoles avec des derives d'aziridine

Country Status (16)

Country Link
JP (1) JPS55500026A (fr)
CS (1) CS207750B2 (fr)
DE (1) DE2857324D2 (fr)
DK (1) DK319679A (fr)
FI (1) FI784018A (fr)
FR (1) FR2413373A1 (fr)
GB (1) GB2036003B (fr)
GR (1) GR65283B (fr)
IT (1) IT1102765B (fr)
NL (1) NL171054C (fr)
NO (1) NO784350L (fr)
PL (1) PL113033B1 (fr)
SE (1) SE7907148L (fr)
SU (1) SU950188A3 (fr)
WO (1) WO1979000466A1 (fr)
YU (1) YU313178A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2425434A1 (fr) * 1978-05-12 1979-12-07 Crc Ricerca Chim Thiols derives de l'imidazole utilisables pour la preparation d'antihistaminiques et leur preparation
FR2425429A1 (fr) * 1978-05-12 1979-12-07 Crc Ricerca Chim N-cyano-azomethines utilisables pour la preparation d'antihistaminiques et leur preparation
FR2473044A1 (fr) * 1980-01-08 1981-07-10 Glaxo Group Ltd Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981000255A1 (fr) * 1979-07-16 1981-02-05 Rech Syntheses Organ Imino-alkyle et amino-nitrile cyano-guanidines
WO1981000405A1 (fr) * 1979-07-30 1981-02-19 Rech Syntheses Organ Di-cyano-guanidines
CA1181084A (fr) * 1980-01-08 1985-01-15 Glaxo Group Limited Preparation d'un derive de furane
EP0058286A1 (fr) * 1981-02-12 1982-08-25 Société de Recherches et de Synthèses Organiques SA Isomères géométriques de cyano-guanidines et leurs procédés de préparation
GB8502446D0 (en) * 1985-01-31 1985-03-06 Smith Kline French Lab Preparing aziridine derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2425434A1 (fr) * 1978-05-12 1979-12-07 Crc Ricerca Chim Thiols derives de l'imidazole utilisables pour la preparation d'antihistaminiques et leur preparation
FR2425429A1 (fr) * 1978-05-12 1979-12-07 Crc Ricerca Chim N-cyano-azomethines utilisables pour la preparation d'antihistaminiques et leur preparation
FR2473044A1 (fr) * 1980-01-08 1981-07-10 Glaxo Group Ltd Procede de preparation de la n-(2-((5-((dimethylamino)-methyl)-2-furannylmethyl)-thio)ethyl)-n'-methyl-2-nitro-1,1-ethene-diamine, et produits intermediaires de cette preparation

Also Published As

Publication number Publication date
NO784350L (no) 1979-07-03
JPS55500026A (fr) 1980-01-24
IT1102765B (it) 1985-10-07
SU950188A3 (ru) 1982-08-07
FI784018A (fi) 1979-07-01
GR65283B (en) 1980-08-01
IT7831352A0 (it) 1978-12-28
PL113033B1 (en) 1980-11-29
GB2036003A (en) 1980-06-25
GB2036003B (en) 1982-08-18
YU313178A (en) 1982-10-31
NL7812662A (nl) 1979-07-03
PL212389A1 (pl) 1979-08-13
NL171054B (nl) 1982-09-01
CS207750B2 (en) 1981-08-31
SE7907148L (sv) 1979-08-28
DK319679A (da) 1979-08-30
WO1979000466A1 (fr) 1979-07-26
DE2857324D2 (en) 1980-11-20
NL171054C (nl) 1983-02-01

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