FR2464995A1 - Procede de preparation d'une sous-population virale ayant une sensibilite accrue envers des cellules-hotes du virus et applications de cette sous-population - Google Patents
Procede de preparation d'une sous-population virale ayant une sensibilite accrue envers des cellules-hotes du virus et applications de cette sous-population Download PDFInfo
- Publication number
- FR2464995A1 FR2464995A1 FR8019716A FR8019716A FR2464995A1 FR 2464995 A1 FR2464995 A1 FR 2464995A1 FR 8019716 A FR8019716 A FR 8019716A FR 8019716 A FR8019716 A FR 8019716A FR 2464995 A1 FR2464995 A1 FR 2464995A1
- Authority
- FR
- France
- Prior art keywords
- virus
- cells
- viral
- process according
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 title claims abstract description 57
- 230000003612 virological effect Effects 0.000 title claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000035945 sensitivity Effects 0.000 title description 6
- 210000004027 cell Anatomy 0.000 claims abstract description 64
- 238000000034 method Methods 0.000 claims abstract description 34
- 239000000758 substrate Substances 0.000 claims abstract description 21
- 230000008569 process Effects 0.000 claims abstract description 16
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 14
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 11
- 210000000170 cell membrane Anatomy 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims abstract description 6
- 239000012634 fragment Substances 0.000 claims abstract description 4
- 241000711408 Murine respirovirus Species 0.000 claims description 26
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 10
- 102000003886 Glycoproteins Human genes 0.000 claims description 8
- 108090000288 Glycoproteins Proteins 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 230000000295 complement effect Effects 0.000 claims description 6
- 230000003278 mimic effect Effects 0.000 claims description 4
- KPAIBEKNDBAQDX-AKKDPBBWSA-N (4S,5R,6R)-5-amino-2,4-dihydroxy-3-(2-hydroxyacetyl)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid Chemical compound C(CO)(=O)C1C(C(O)=O)(O)O[C@H]([C@@H]([C@H]1O)N)[C@H](O)[C@H](O)CO KPAIBEKNDBAQDX-AKKDPBBWSA-N 0.000 claims description 3
- 241000712461 unidentified influenza virus Species 0.000 claims description 3
- 102000014914 Carrier Proteins Human genes 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- KBGAYAKRZNYFFG-BOHATCBPSA-N aceneuramic acid Chemical compound OC(=O)C(=O)C[C@H](O)[C@@H](NC(=O)C)[C@@H](O)[C@H](O)[C@H](O)CO KBGAYAKRZNYFFG-BOHATCBPSA-N 0.000 claims description 2
- 108091008324 binding proteins Proteins 0.000 claims description 2
- 210000000416 exudates and transudate Anatomy 0.000 claims description 2
- 230000036651 mood Effects 0.000 claims description 2
- 238000003127 radioimmunoassay Methods 0.000 claims description 2
- 230000031018 biological processes and functions Effects 0.000 claims 1
- 230000009137 competitive binding Effects 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 125000005629 sialic acid group Chemical group 0.000 claims 1
- 238000009739 binding Methods 0.000 abstract description 5
- 102000005962 receptors Human genes 0.000 description 32
- 108020003175 receptors Proteins 0.000 description 32
- 239000011521 glass Substances 0.000 description 14
- 102000013361 fetuin Human genes 0.000 description 10
- 108060002885 fetuin Proteins 0.000 description 10
- 239000000499 gel Substances 0.000 description 9
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 8
- 239000003446 ligand Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
- 229920002684 Sepharose Polymers 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 5
- 241000283707 Capra Species 0.000 description 5
- 241001494479 Pecora Species 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 229910052740 iodine Inorganic materials 0.000 description 5
- 239000011630 iodine Substances 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 102000018697 Membrane Proteins Human genes 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 108010066342 Virus Receptors Proteins 0.000 description 2
- 102000018265 Virus Receptors Human genes 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- -1 acryl- Chemical group 0.000 description 2
- 150000004982 aromatic amines Chemical class 0.000 description 2
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000010668 complexation reaction Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- BJOZNDRNJJZHPZ-LUWBGTNYSA-N 9-O-acetylneuraminic acid Chemical compound CC(=O)OC[C@@H](O)[C@@H](O)[C@@H]1OC(O)(C(O)=O)C[C@H](O)[C@H]1N BJOZNDRNJJZHPZ-LUWBGTNYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 241000714266 Bovine leukemia virus Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 108010058683 Immobilized Proteins Proteins 0.000 description 1
- 102100034349 Integrase Human genes 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical group CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 101710126065 Submaxillary mucin Proteins 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000005289 controlled pore glass Substances 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000037189 immune system physiology Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108010061514 sialic acid receptor Proteins 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 230000007501 viral attachment Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18811—Sendai virus
- C12N2760/18851—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/074,918 US4282315A (en) | 1979-09-13 | 1979-09-13 | Preparation of enriched whole virus radioligand |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2464995A1 true FR2464995A1 (fr) | 1981-03-20 |
| FR2464995B1 FR2464995B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-03-01 |
Family
ID=22122432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8019716A Granted FR2464995A1 (fr) | 1979-09-13 | 1980-09-12 | Procede de preparation d'une sous-population virale ayant une sensibilite accrue envers des cellules-hotes du virus et applications de cette sous-population |
Country Status (6)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2450877A1 (fr) * | 1979-03-06 | 1980-10-03 | Inst Nat Sante Rech Med | Nouveaux tests par agglutination pour la detection des virus de la grippe, et reactifs pour la realisation de ces tests |
| US4375459A (en) * | 1980-06-20 | 1983-03-01 | The Regents Of The University Of California | Cytoreceptor assay |
| US4743678A (en) * | 1983-04-27 | 1988-05-10 | President And Fellows Of Harvard College | Method and products for detection of human T cell leukemia virus |
| US5045448A (en) * | 1983-04-27 | 1991-09-03 | President And Fellows Of Harvard College | Method and products for detection of human T cell leukemia virus |
| DE3590116T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1984-03-19 | 1987-02-19 | ||
| US4797363A (en) * | 1984-03-19 | 1989-01-10 | Board Of Trustees, University Of Illinois | Bacteriophages as recognition and identification agents |
| AU1043788A (en) * | 1986-12-01 | 1988-06-30 | Mcdonnell Douglas Corporation | Method of identifying unknown organisms |
| US4869826A (en) * | 1987-09-01 | 1989-09-26 | Process Biotechnology, Inc. | Cellular adsorbents for removal of viral contaminants from blood and complex protein solutions |
| JPH05219994A (ja) * | 1990-01-24 | 1993-08-31 | Amoco Corp | シグナル産生部分およびその使用法 |
| US5168037A (en) * | 1990-08-02 | 1992-12-01 | Phyllis Entis | Method for the preparation of a labelled virus without the inactivation of viral binding sites and method of assay utilizing said labelled virus |
| DE4119085A1 (de) * | 1991-06-10 | 1992-12-17 | Pallmann Biotechnik Gmbh Dr | Verfahren zur detektion und/oder quantitativen bestimmung von 9-n/o-acetylierten sialinsaeuren |
| EP1486211B1 (en) | 1993-04-30 | 2008-10-22 | Wellstat Biologics Corporation | Compositions for treating cancer using viruses |
| BR9506962A (pt) * | 1994-03-01 | 1997-09-16 | Merck Patent Gmbh | Cultura seletiva de virus |
| US5851395A (en) * | 1995-12-25 | 1998-12-22 | Kawase; Mitsuo | Virus-removing filter |
| CA2333463A1 (en) | 1998-06-04 | 1999-12-09 | Microsens Biophage Limited | Analytical method using multiple virus labelling |
| CN101058800B (zh) * | 2002-07-09 | 2013-03-13 | 巴克斯特国际有限公司 | 用于细胞培养的无动物蛋白质培养基 |
| EP1602928A1 (en) * | 2004-06-01 | 2005-12-07 | Universiteit Maastricht | Process and kit for determining binding parameters of bioaffinity binding reactions |
| KR102041771B1 (ko) * | 2018-07-02 | 2019-11-07 | 한국과학기술원 | 저소음 고음질 헤어드라이어 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178360A (en) * | 1978-03-15 | 1979-12-11 | Hoffmann-La Roche Inc. | Radiolabelled rubella virus and method |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3826613A (en) * | 1973-03-06 | 1974-07-30 | Us Navy | Detection and titration of viruses and antibodies using latex |
| JPS5048119A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-08-31 | 1975-04-30 | ||
| JPS5537530B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-11-28 | 1980-09-29 | ||
| US4176174A (en) * | 1974-07-19 | 1979-11-27 | Burroughs Wellcome Co. | Viral antibody diagnostic test system |
| JPS5157816A (en) * | 1974-11-16 | 1976-05-20 | Le Borichefuechesukii I Imeeni | Wakuchinno seizoho |
| IL49752A (en) * | 1975-07-09 | 1979-07-25 | Kabi Ab | Compositions having affinity for hepatitis virus and method for hepatitis virus removal or concentration |
| US4195074A (en) * | 1977-03-01 | 1980-03-25 | Abbott Laboratories | Process for producing a soluble rubella antigen |
-
1979
- 1979-09-13 US US06/074,918 patent/US4282315A/en not_active Expired - Lifetime
-
1980
- 1980-08-13 CA CA000358143A patent/CA1153308A/en not_active Expired
- 1980-09-11 DE DE19803034142 patent/DE3034142A1/de active Granted
- 1980-09-11 GB GB8029459A patent/GB2060690B/en not_active Expired
- 1980-09-12 FR FR8019716A patent/FR2464995A1/fr active Granted
- 1980-09-12 JP JP12700880A patent/JPS56102786A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178360A (en) * | 1978-03-15 | 1979-12-11 | Hoffmann-La Roche Inc. | Radiolabelled rubella virus and method |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3034142A1 (de) | 1981-04-02 |
| FR2464995B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-03-01 |
| DE3034142C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-02-01 |
| JPS56102786A (en) | 1981-08-17 |
| GB2060690A (en) | 1981-05-07 |
| JPH0223157B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-05-23 |
| CA1153308A (en) | 1983-09-06 |
| US4282315A (en) | 1981-08-04 |
| GB2060690B (en) | 1983-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2464995A1 (fr) | Procede de preparation d'une sous-population virale ayant une sensibilite accrue envers des cellules-hotes du virus et applications de cette sous-population | |
| Updyke et al. | Immunoaffinity isolation of membrane antigens with biotinylated monoclonal antibodies and immobilized streptavidin matrices | |
| JPS60501573A (ja) | 新規な視覚化ポリマ−及びこれらのポリマ−の診断薬への応用 | |
| JPH07108919B2 (ja) | 複特異性抗体決定子 | |
| JPS61502417A (ja) | ポリクロナ−ル抗体、製法と用途 | |
| JPS58203919A (ja) | 免疫グロブリン半分子および交雑種抗体を製造する方法 | |
| EP0655136B1 (fr) | Dispositif pour le dosage d'haptenes et son utilisation | |
| JPH0322946B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| FR2500009A1 (fr) | Procede et systeme de necessaire experimental diagnostique pour determiner quantitativement la presence de la forme isoenzymatique mb de la creatine kinase | |
| JPS59202064A (ja) | 抗原決定基具有物質を測定する方法 | |
| JP3327488B2 (ja) | 被検体の免疫化学的測定方法 | |
| JPH06505340A (ja) | 分析的な試薬の生産方法 | |
| Meusel et al. | Development of a heterogeneous amperometric immunosensor for the determination of apolipoprotein E in serum | |
| JP3808527B2 (ja) | 特異的結合方法および試験キット | |
| FR2701319A1 (fr) | Procédé de détection et/ou de dosage de composés viraux et support portant une glycoprotéine. | |
| JPH05295000A (ja) | 共有結合的交雑種抗体、その調製法およびこれを使用する均質的免疫検定法 | |
| JPS62246596A (ja) | 改質β↓２マイクログロブリン | |
| FR2523311A1 (fr) | Produit de couplage entre une albumine et un ligand specifique, obtention et applications dans le domaine biologique | |
| CA2148268A1 (fr) | Methode d'immunodosage specifique de la glutathion peroxydase plasmatique humaine | |
| JP3400507B2 (ja) | 特異的結合パートナーと炭水化物含有蛋白質から構成される複合体の製造方法 | |
| EP2660603B1 (en) | Immunological assay method | |
| EP0255431B1 (fr) | Thymidine kinase de type foetal purifiée | |
| EP1364208B1 (en) | Conjugates of defined stoichiometry | |
| JP3345507B2 (ja) | アシアログリコプロテインレセプターの測定法及びこれに用いる測定試薬 | |
| JPS61202162A (ja) | ヒト血中のヒトプロリルヒドロキシラーゼの酵素免疫定量法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |