FR2458538B1 - - Google Patents

Info

Publication number
FR2458538B1
FR2458538B1 FR7927754A FR7927754A FR2458538B1 FR 2458538 B1 FR2458538 B1 FR 2458538B1 FR 7927754 A FR7927754 A FR 7927754A FR 7927754 A FR7927754 A FR 7927754A FR 2458538 B1 FR2458538 B1 FR 2458538B1
Authority
FR
France
Prior art keywords
lower alkyl
leucyl
phenylalanyl
alanyl
naphthyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7927754A
Other languages
English (en)
Other versions
FR2458538A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Priority to IT22519/80A priority Critical patent/IT1149971B/it
Priority to PT71366A priority patent/PT71366A/pt
Priority to CS804093A priority patent/CS228133B2/cs
Priority to CA000353717A priority patent/CA1157851A/fr
Priority to AT80103222T priority patent/ATE9089T1/de
Priority to DE19803021736 priority patent/DE3021736A1/de
Priority to GR62171A priority patent/GR69259B/el
Priority to DE1993175028 priority patent/DE19375028I2/de
Priority to IL60282A priority patent/IL60282A/xx
Priority to GB8018874A priority patent/GB2054603B/en
Priority to DE8080103222T priority patent/DE3069013D1/de
Priority to IE1193/80A priority patent/IE49946B1/en
Priority to DD80221687A priority patent/DD152542A5/de
Priority to NO801729A priority patent/NO151896C/no
Priority to NZ193984A priority patent/NZ193984A/xx
Priority to ES492289A priority patent/ES492289A0/es
Priority to AU59176/80A priority patent/AU539495B2/en
Priority to FI801856A priority patent/FI72527C/fi
Priority to EP80103222A priority patent/EP0021234B1/fr
Priority to PL1980224852A priority patent/PL126655B1/pl
Priority to DK248880A priority patent/DK149046C/da
Priority to YU1553/80A priority patent/YU42217B/xx
Priority to SI8011553A priority patent/SI8011553A8/sl
Publication of FR2458538A1 publication Critical patent/FR2458538A1/fr
Priority to DK079384A priority patent/DK152734C/da
Publication of FR2458538B1 publication Critical patent/FR2458538B1/fr
Application granted granted Critical
Priority to HK174/86A priority patent/HK17486A/xx
Priority to MY324/86A priority patent/MY8600324A/xx
Priority to YU82387A priority patent/YU46315B/sh
Priority to NL930103C priority patent/NL930103I2/nl
Priority to NO1994006C priority patent/NO1994006I1/no
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR7927754A 1979-06-11 1979-11-09 Derives nonapeptidiques et decapeptidiques de l'hormone liberant l'hormone luteinisante, leur procede de production et composition pharmaceutique les contenant Granted FR2458538A1 (fr)

Priority Applications (29)

Application Number Priority Date Filing Date Title
IT22519/80A IT1149971B (it) 1979-06-11 1980-06-03 Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante
PT71366A PT71366A (en) 1979-06-11 1980-06-09 Process for preparing nonapeptides and decapeptides derivatives of luteinizing hormone releasing hormone
EP80103222A EP0021234B1 (fr) 1979-06-11 1980-06-10 Dérivés nona- décapeptidiques de l'hormone libérant l'hormone lutéinisante, leur préparation et compositions pharmaceutiques les contenant
AU59176/80A AU539495B2 (en) 1979-06-11 1980-06-10 Nonapeptide and decapeptide derivatives
DE19803021736 DE3021736A1 (de) 1979-06-11 1980-06-10 Neue peptide, verfahren zu deren herstellung und diese enthaltenden arzneimittel
GR62171A GR69259B (fr) 1979-06-11 1980-06-10
DE1993175028 DE19375028I2 (de) 1979-06-11 1980-06-10 Nonapeptid- und Dekapeptid- Derivate des das luteinisierende Hormon freisetzenden Hormons ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IL60282A IL60282A (en) 1979-06-11 1980-06-10 Nonapeptide and decapeptide derivatives of lh releasing hormone,their preparation and pharmaceutical compositions containing them
GB8018874A GB2054603B (en) 1979-06-11 1980-06-10 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
DE8080103222T DE3069013D1 (en) 1979-06-11 1980-06-10 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them
IE1193/80A IE49946B1 (en) 1979-06-11 1980-06-10 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
DD80221687A DD152542A5 (de) 1979-06-11 1980-06-10 Verfahren zur herstellung neuer peptide
CA000353717A CA1157851A (fr) 1979-06-11 1980-06-10 Derives nonapeptides et decapeptides de l'hormone de liberation de la luteinostimuline
NZ193984A NZ193984A (en) 1979-06-11 1980-06-10 Nona- and deca- peptide analogues of luteinizing hormone releasing hormone and pharmaceutical compositions
CS804093A CS228133B2 (en) 1979-06-11 1980-06-10 Production method of nonpeptide and decapeptide derivative of hormone releasing luteinizae hormone
AT80103222T ATE9089T1 (de) 1979-06-11 1980-06-10 Nonapeptid- und dekapeptid-derivate des das luteinisierende hormon freisetzenden hormons, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES492289A ES492289A0 (es) 1979-06-11 1980-06-10 Procedimiento para la preparacion de derivados de nonapepti-dos y decapeptidos de hormona liberadora de hormona luteini-zante
NO801729A NO151896C (no) 1979-06-11 1980-06-10 Analogifremgangsmaate for fremstilling av terapeutisk virksomme nonapeptid- og dekapeptidderivater av det hormon som frigjoer det luteiniserende hormon
PL1980224852A PL126655B1 (en) 1979-06-11 1980-06-10 Method for producing rew derivatives of nonapeptides and decarentides
DK248880A DK149046C (da) 1979-06-11 1980-06-10 Analogifremgangsmaade til fremstilling af lhrh-analoge nonapeptid- ogdecapeptidderivater eller farmaceutisk acceptable salte deraf
FI801856A FI72527C (fi) 1979-06-11 1980-06-10 Foerfarande foer framstaellning av en terapeutiskt anvaendbar polypeptid.
YU1553/80A YU42217B (en) 1979-06-11 1980-06-11 Process for obtaining nonapeptidic and decapeptidic derivatives of hormone for releasing luteinisating hormone
SI8011553A SI8011553A8 (sl) 1979-06-11 1980-06-11 Postopek za pripravo nonapeptidnih in dekapeptidnih derivatov hormonov za sproščanje luteinizirajočega hormona
DK079384A DK152734C (da) 1979-06-11 1984-02-20 Lhrh-analoge nonapeptid- og decapeptidderivater og farmaceutisk acceptable salte deraf og middel til kontraception
HK174/86A HK17486A (en) 1979-06-11 1986-03-13 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone,their preparation and pharmaceutical compositions containing them
MY324/86A MY8600324A (en) 1979-06-11 1986-12-30 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them
YU82387A YU46315B (sh) 1979-06-11 1987-05-08 Postupak za dobijanje nonapeptidnih i dekapeptidnih derivata hormona za oslobadjanje luteinizirajućeg hormona
NL930103C NL930103I2 (nl) 1979-06-11 1993-06-28 Nonapeptide- en decapeptidederivaten van tot afgifte van luteiniserend hormoon aanzettend hormoon, bereiding daarvan en farmaceutische preparaten, di e deze bevatten.
NO1994006C NO1994006I1 (no) 1979-06-11 1994-07-29 Nafarelin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/047,661 US4234571A (en) 1979-06-11 1979-06-11 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone

Publications (2)

Publication Number Publication Date
FR2458538A1 FR2458538A1 (fr) 1981-01-02
FR2458538B1 true FR2458538B1 (fr) 1984-10-19

Family

ID=21950237

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7927754A Granted FR2458538A1 (fr) 1979-06-11 1979-11-09 Derives nonapeptidiques et decapeptidiques de l'hormone liberant l'hormone luteinisante, leur procede de production et composition pharmaceutique les contenant

Country Status (12)

Country Link
US (1) US4234571A (fr)
JP (3) JPS55164663A (fr)
KR (1) KR840001921B1 (fr)
AT (1) ATE9089T1 (fr)
FR (1) FR2458538A1 (fr)
HU (1) HU185379B (fr)
LU (1) LU88272I2 (fr)
MX (1) MX9203594A (fr)
NO (1) NO1994006I1 (fr)
SI (1) SI8011553A8 (fr)
SU (2) SU1681733A3 (fr)
ZA (1) ZA803453B (fr)

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US5389613A (en) * 1979-09-21 1995-02-14 Roussel Uclaf Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis
FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
GB2089209B (en) * 1980-06-26 1984-09-05 Salk Inst For Biological Studi Contraceptive treatment of male mammals
US4382922A (en) * 1980-08-29 1983-05-10 The Salk Institute For Biological Studies Peptides affecting gonadal function
US4419347A (en) * 1980-10-06 1983-12-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
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US5366734A (en) * 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
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Also Published As

Publication number Publication date
JPS63264498A (ja) 1988-11-01
KR840001921B1 (ko) 1984-10-25
US4234571A (en) 1980-11-18
HU185379B (en) 1985-01-28
JPS55164663A (en) 1980-12-22
MX9203594A (es) 1992-07-01
LU88272I2 (fr) 1994-02-03
KR830002804A (ko) 1983-05-30
JPH0371439B2 (fr) 1991-11-13
ATE9089T1 (de) 1984-09-15
JPS6425794A (en) 1989-01-27
FR2458538A1 (fr) 1981-01-02
SU1681733A3 (ru) 1991-09-30
NO1994006I1 (no) 1994-07-29
JPH0371438B2 (fr) 1991-11-13
ZA803453B (en) 1982-01-27
SU1428205A3 (ru) 1988-09-30
JPS6356238B2 (fr) 1988-11-07
SI8011553A8 (sl) 1998-02-28

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