KR830002804A - 황체 형성 호르몬 방출 호르몬의 노나펩티드 및 데카펩티드의 제조방법 - Google Patents

황체 형성 호르몬 방출 호르몬의 노나펩티드 및 데카펩티드의 제조방법 Download PDF

Info

Publication number
KR830002804A
KR830002804A KR1019800002276A KR800002276A KR830002804A KR 830002804 A KR830002804 A KR 830002804A KR 1019800002276 A KR1019800002276 A KR 1019800002276A KR 800002276 A KR800002276 A KR 800002276A KR 830002804 A KR830002804 A KR 830002804A
Authority
KR
South Korea
Prior art keywords
formula
compound
lower alkyl
salt
pharmacologically acceptable
Prior art date
Application number
KR1019800002276A
Other languages
English (en)
Other versions
KR840001921B1 (ko
Inventor
조셉 네스터 존
헨리 존즈 고오든
헨리 비커리 브라이안
Original Assignee
버어튼 엘. 로저스
신텍스 (미합중국) 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 버어튼 엘. 로저스, 신텍스 (미합중국) 인코포레이티드 filed Critical 버어튼 엘. 로저스
Publication of KR830002804A publication Critical patent/KR830002804A/ko
Application granted granted Critical
Publication of KR840001921B1 publication Critical patent/KR840001921B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

황체 형성 호르몬 방출 호르몬의 노나펩티드 및 데카펩티드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 공지의 폴리펩티드 합성법에 따라 하기 아미노산 서열을 갖는 일반식(Ⅰ)의 화합물 또는 그의 약리학상 허용되는 염을 제조함에 있어서,
  2. i) 보호기, 또는 보호된 폴리펩티드로부터 공유 결합된 고체담체를 제거하여 하기 일반식(Ⅰ)의 화합물 또는 그의 염을 얻고, 경우에 따라서는
  3. ii) 하기 일반식(Ⅰ)의 화합물을 약리학상 허용되는 염으로 전환시키거나, 또는
  4. iii)하기 일반식(Ⅰ)의 화합물의 염을 그의 약리학상 허용되는 염으로 전환시키거나, 또는
  5. ⅳ)하기 일반식(Ⅰ)의 화합물의 염을 분해시켜 하기 일반식(Ⅰ)의 유리폴리펩티드로 변화시키는 것을 특징으로 하는 황체 형성 호르몬 방출 호르몬의 노나펩티드 및 데카펩티드의 제조 방법.
  7. 상기 식에서,
  8. V는 트리프로필, 페닐알라닐 또는 3-(1-4 프릴)-L-알라닐이고,
  9. W는 티로실, 페닐알라닐 또는 3-(1-펜타플루오로-페닐)-L-알라닐이고,
  10. X는 하기 구조식의 D-아미노산 잔기
  12. [단, 여기서, R는,
  13. (a) 3개 이상의 직쇄 저급 알킬기로 치환된 나프틸, 안트릴, 플루오로에닐, 페난트릴, 비페니릴, 벤즈히드릴 및 페닐중에서 선정된 카르복실산 아릴 함유잔기이고,
  14. (b) 3개 이상의 직쇄 저급 알킬기로 치환된 시클로 핵실, 피히드로나프틸, 피히드로비페닐, 피히드로-2,2-디페닐메틸 및 아다만틸 중에서 선정된 포화카르복실산 잔기이다.]
  15. 이고,
  16. Y는 로이실, 이소로이실, 노르-로이실 또는 N-메틸-로이실이며,
  17. Z는 글리신아미드 또는 -NH-R1[단, 여기서, R1은 저급알킬, 시클로알킬, 플루오로 저급 알킬 또는(단, 여기서, R2는 수소 또는 저급 알킬이다)이다] 이다.
  18. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800002276A 1979-06-11 1980-06-10 데카펩티드의 제조방법 KR840001921B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/047,661 US4234571A (en) 1979-06-11 1979-06-11 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US47661 1987-05-08

Publications (2)

Publication Number Publication Date
KR830002804A true KR830002804A (ko) 1983-05-30
KR840001921B1 KR840001921B1 (ko) 1984-10-25

Family

ID=21950237

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800002276A KR840001921B1 (ko) 1979-06-11 1980-06-10 데카펩티드의 제조방법

Country Status (12)

Country Link
US (1) US4234571A (ko)
JP (3) JPS55164663A (ko)
KR (1) KR840001921B1 (ko)
AT (1) ATE9089T1 (ko)
FR (1) FR2458538A1 (ko)
HU (1) HU185379B (ko)
LU (1) LU88272I2 (ko)
MX (1) MX9203594A (ko)
NO (1) NO1994006I1 (ko)
SI (1) SI8011553A8 (ko)
SU (2) SU1681733A3 (ko)
ZA (1) ZA803453B (ko)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
US5389613A (en) * 1979-09-21 1995-02-14 Roussel Uclaf Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
WO1982000004A1 (en) * 1980-06-26 1982-01-07 Salk Inst For Biological Studi Contraceptive treatment of male mammals
US4382922A (en) * 1980-08-29 1983-05-10 The Salk Institute For Biological Studies Peptides affecting gonadal function
US4419347A (en) * 1980-10-06 1983-12-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US5366734A (en) * 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS58125819U (ja) * 1982-02-19 1983-08-26 名伸電機株式会社 積算電力量計用パツキン
HU185535B (en) * 1982-05-25 1985-02-28 Mta Koezponti Hivatala Process for preparing new gonadoliberin derivatives
US4619914A (en) * 1983-03-10 1986-10-28 The Salk Institute For Biological Studies GNRH antagonists IIIB
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4652550A (en) * 1984-05-21 1987-03-24 The Salk Institute For Biological Studies GnRH antagonists VII
US4632979A (en) * 1984-06-18 1986-12-30 Tulane Educational Fund Therapeutic LHRH analogs
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4565804A (en) * 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0190891A3 (en) * 1985-01-31 1988-04-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
US4656247A (en) * 1985-04-26 1987-04-07 Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-QA1 6-LHRH
US4642332A (en) * 1985-04-26 1987-02-10 The Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-Pal6 -LHRH
EP0206807A3 (en) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
HU194280B (en) * 1985-10-22 1988-01-28 Richter Gedeon Vegyeszet Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
US4762717A (en) * 1986-03-21 1988-08-09 The General Hospital Corporation Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
US4761398A (en) * 1986-08-18 1988-08-02 Embrex, Inc. Method of inducing birds to molt
US5028430A (en) * 1987-05-08 1991-07-02 Syntex (U.S.A.) Inc. Delivery systems for the controlled administration of LHRH analogs
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
NO179479C (no) * 1988-03-11 1996-10-16 Teikoku Seiyaku Kk Fremgangsmåte for fremstilling av et intravaginalt farmasöytisk preparat
JP2672677B2 (ja) * 1989-02-09 1997-11-05 タツプ・フアーマシユーテイカルズ・インコーポレイテツド Ｌｈｒｈ同族体
JPH02235975A (ja) * 1989-03-09 1990-09-18 Masaya Takinami 粘着シート
US6156731A (en) * 1989-05-10 2000-12-05 G. D. Searle & Co. Polypeptide composition for oral administration
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
JP2911496B2 (ja) * 1989-09-11 1999-06-23 帝國製薬株式会社 生理活性ポリペプチド含有高吸収性経膣剤
US5580957A (en) * 1989-10-30 1996-12-03 The Salk Institute For Biological Studies GnRH analogs
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
JP2653255B2 (ja) 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル
US5212288A (en) * 1990-02-20 1993-05-18 Syntex (U.S.A.) Inc. Temporary minimal protection synthesis of serine-containing polypeptides
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
JPH05117604A (ja) * 1990-11-01 1993-05-14 Koopack Kk 粘着シールによる表示製品
US5744450A (en) 1991-03-14 1998-04-28 The Salk Institute For Biological Studies GnRH analogs
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
EP1008656A4 (en) 1996-06-13 2000-09-20 Itoham Foods Inc METHOD FOR PRODUCING LH-RH DERIVATIVES
US6458357B1 (en) * 1997-09-09 2002-10-01 Myelos Corporation Retro-inverso neurotrophic and analgesic peptides
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
US20040265285A1 (en) * 1999-04-15 2004-12-30 Monash University Normalization of defective T cell responsiveness through manipulation of thymic regeneration
AUPR074500A0 (en) * 2000-10-13 2000-11-09 Monash University Treatment of t cell disorders
US20050020524A1 (en) * 1999-04-15 2005-01-27 Monash University Hematopoietic stem cell gene therapy
US20040259803A1 (en) * 1999-04-15 2004-12-23 Monash University Disease prevention by reactivation of the thymus
US20040241842A1 (en) * 1999-04-15 2004-12-02 Monash University Stimulation of thymus for vaccination development
US20070274946A1 (en) * 1999-04-15 2007-11-29 Norwood Immunoloty, Ltd. Tolerance to Graft Prior to Thymic Reactivation
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
US20060088512A1 (en) * 2001-10-15 2006-04-27 Monash University Treatment of T cell disorders
US20060287282A1 (en) * 2001-06-25 2006-12-21 Steiner Mitchell S Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
US20030144203A1 (en) * 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
GB0307777D0 (en) * 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
CA2524286A1 (en) * 2003-05-01 2004-11-18 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Li Mited Nasal administration of the lh-rh analog leuprolide
GB0320806D0 (en) 2003-09-05 2003-10-08 Astrazeneca Ab Therapeutic treatment
US20080279812A1 (en) * 2003-12-05 2008-11-13 Norwood Immunology, Ltd. Disease Prevention and Vaccination Prior to Thymic Reactivation
RU2522634C2 (ru) * 2012-07-31 2014-07-20 Общество с ограниченной ответственностью "Научно-производственное предприятие "ИнБио Текс" Способ получения трудногорючих полимерных изделий на основе полиэтилентерефталата с биоцидными свойствами

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5314072B2 (ko) * 1973-09-29 1978-05-15
JPS5726506B2 (ko) * 1974-03-08 1982-06-04
JPS50142563A (ko) * 1974-04-26 1975-11-17
DE2438350C3 (de) * 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4018726A (en) * 1975-06-12 1977-04-19 Andrew Victor Schally [D-Phe6 ]-LH-RH and intermediates therefor
NZ181036A (en) * 1975-06-12 1978-12-18 A Schally Luteinising hormone releasing hormone analogues and intermediates therefor
US4010125A (en) * 1975-06-12 1977-03-01 Schally Andrew Victor [D-Trp6 ]-LH-RH and intermediates therefor
US4005194A (en) * 1975-06-23 1977-01-25 Abbott Laboratories Treatment of prostatic hyperplasia
FR2329293A1 (fr) * 1975-10-29 1977-05-27 Parke Davis & Co Nouveaux nonapeptides et procedes pour leur production
US3992530A (en) * 1975-12-08 1976-11-16 American Home Products Corporation [D-2-(1,4-Cyclohexadienyl)gly]6 -des-gly10 -lrh nonapeptide amides
US4071622A (en) * 1976-02-11 1978-01-31 Abbott Laboratories Treatment of a mammary or DMBA inducible tumor
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
US4089946A (en) * 1976-06-07 1978-05-16 American Home Products Corporation Claudogenic-interceptive nonapeptides
US4143133A (en) * 1977-10-03 1979-03-06 American Home Products Corporation Claudogenic-interceptive nonapeptides
JPS5855137B2 (ja) * 1977-10-07 1983-12-08 武田薬品工業株式会社 ポリペプチドの製造法

Also Published As

Publication number Publication date
JPH0371438B2 (ko) 1991-11-13
MX9203594A (es) 1992-07-01
NO1994006I1 (no) 1994-07-29
FR2458538A1 (fr) 1981-01-02
FR2458538B1 (ko) 1984-10-19
KR840001921B1 (ko) 1984-10-25
JPS6356238B2 (ko) 1988-11-07
LU88272I2 (ko) 1994-02-03
US4234571A (en) 1980-11-18
SU1428205A3 (ru) 1988-09-30
ZA803453B (en) 1982-01-27
JPS6425794A (en) 1989-01-27
JPH0371439B2 (ko) 1991-11-13
ATE9089T1 (de) 1984-09-15
HU185379B (en) 1985-01-28
SU1681733A3 (ru) 1991-09-30
JPS63264498A (ja) 1988-11-01
SI8011553A8 (sl) 1998-02-28
JPS55164663A (en) 1980-12-22

Similar Documents

Publication Publication Date Title
KR830002804A (ko) 황체 형성 호르몬 방출 호르몬의 노나펩티드 및 데카펩티드의 제조방법
KR830004221A (ko) 사이클로 옥타펩타이드의 제조방법
HUT47311A (en) Process for producing lhrh antagonists and pharmaceuticals comprising same
KR850004594A (ko) 펩타이드의 제조방법
IE812322L (en) Nonapeptides and decapeptides
KR840009069A (ko) 향정신성 펩티드류의 제조 방법
ES8104201A1 (es) Procedimiento para la preparacion de derivados de nonapepti-dos y decapeptidos de hormona liberadora de hormona luteini-zante
CO5150192A1 (es) Nuevos antagonistas de la lhrh que contienen componentes de aminoacido n-metilados con propiedades mejoradas de solubilidad
KR910016767A (ko) 신규한 펩티드
KR850001774A (ko) Lh/rh길항성 펩티드의 제조방법
DK173082A (da) Fremgangsmaade til fremstilling af peptider,der inhiberer frigoerelsen af gonadotropiner
KR830007522A (ko) 흉선(胸腺)활성을 가진 데카-운데카-도데카- 및 트리데카펩티드의 제조방법
ATE70278T1 (de) Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und und ihre verwendung.
KR850002834A (ko) 염기성 헵타 펩타이드 바조프레신 길항근의 제조방법
KR840006208A (ko) 7-아닐리노이소퀴놀린-5,8-퀴논의 제조방법
KR900007776A (ko) 나프탈렌 유도체의 제조방법
KR850002986A (ko) 2-디옥사시클로알킬티오페넴 유도체의 제조방법
KR860002577A (ko) A-21978c 사이클릭 펩타이드 유도체의 제조방법
KR830005096A (ko) 알파-할로케탈류의 재배열을 통한 알카노인산의 에스테르류를 제조하는 방법
KR940014433A (ko) 감마(γ)-엘(L)-글루타밀-엘(L)-시스테인 에틸 에스테르의 제조방법
KR830002760A (ko) 세팔로스포린 유연체의 제조방법
TH1657EX (th) กรรมวิธีการผลิตสารจีเอนอาร์เอช iii