KR830007522A - 흉선(胸腺)활성을 가진 데카-운데카-도데카- 및 트리데카펩티드의 제조방법 - Google Patents
흉선(胸腺)활성을 가진 데카-운데카-도데카- 및 트리데카펩티드의 제조방법 Download PDFInfo
- Publication number
- KR830007522A KR830007522A KR1019810004963A KR810004963A KR830007522A KR 830007522 A KR830007522 A KR 830007522A KR 1019810004963 A KR1019810004963 A KR 1019810004963A KR 810004963 A KR810004963 A KR 810004963A KR 830007522 A KR830007522 A KR 830007522A
- Authority
- KR
- South Korea
- Prior art keywords
- pro
- leu
- formula
- protecting group
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- 210000001541 thymus gland Anatomy 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- ZKQOUHVVXABNDG-IUCAKERBSA-N Pro-Leu Chemical group CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 ZKQOUHVVXABNDG-IUCAKERBSA-N 0.000 claims 3
- HATVCTYBNCNMAA-AVGNSLFASA-N Pro-Leu-Met Chemical group [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(O)=O HATVCTYBNCNMAA-AVGNSLFASA-N 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000007522 mineralic acids Chemical class 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 108010090894 prolylleucine Chemical group 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- VLJNHYLEOZPXFW-BYPYZUCNSA-N L-prolinamide Chemical compound NC(=O)[C@@H]1CCCN1 VLJNHYLEOZPXFW-BYPYZUCNSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N THREONINE Chemical compound CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 125000001288 lysyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/18—Thymus derived hormone or factor; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 하기 일반식(I)을 가진 펩티트와 약리학적으로 허용되는 그 염류를 제조하는 방법에 있어서,상기 일반식에서,A,A′ 및 A″는 각각 독립해서 Gly, D-Ala, D-Leu 또는 D-Trp이고, 여기서 A는 N-알킬화되거나 N-아실화된 것이며,B는 Pro, Δ³-Pro, Thz 또는 diMeThz이고,C와 C′는 각각 독립해서 Thr, Ser, Val 또는 alloThr이며,D는 Clu, Cln, Asp 도는 Asn이고,R는 수소원자 또는 리실 잔기의 ε-아미노기 상에 수소원자들 중의 하나로 치환된 저급 알킬기 또는 저급 아실기이며,X는 Cys,Ala,ABU 또는 Cys(Me)이고Y는 수산기, Pro,Pro-Leu 및 Pro-Leu-Met; - NH₂, ProNH₂, Pro-LeuNH₂ 및 Pro-Leu-MetNH₂로 구성되는 군에서 선택한 것임.(i) 하기 일반식(Ⅱ)를 가진 화합물을 처리하거나,(상기 일반식(Ⅱ)에서 A, A′,A″,B,C,C′,D,R 및 X는 위에서 정의한 바와 같으며, 여기서 Y′는 수산기-NH₂,Pro, Pro-Leu,Pro-Leu-Met,Pro-NH₂,Pro-LeuNH₂ 및 Pro-Leu-MetNH₂; Pro잔기, Pro-Leu잔기 및 Pro-Leu-Met잔기들로 구성되는 군에서 선택된 것이며,P¹,P²,P³,P⁴및 P는 곁가지 사슬보호기인데, 여기서, P¹은 α-아미노기에 알맞는 보호기이며,각 P²는 곁가지 사슬의 수산기에 알맞는 보호기를 각각 나타내고,P³는 곁가지 사슬의 카르복시기에 알맞는 보호기이며,P⁴는 곁가지 사슬의 ε-아미노기에 알맞는 보호기이고,P는 곁가지 사슬의 술포히드릴에 알맞는 보호기이며,S는 카르복시기 또는 고체 중합 지원에 알맞는 보호기이고,각 a,b,c,d,e,f 및 g는 0 또는 1에 해당하는 정수임.(ⅱ) g가 1일때 일반식(I)의 화합물 또는 그 염을 얻기 위하여 고체-지원 분열제로써 일반식(Ⅱ)의 화합물 또는 (i)의 생성물을 처리하거나,(ⅲ) 유기 또는 무기산으로 일반식(Ⅰ)의 화합물을 처리하여 약리학적으로 허용되는 염으로 전환시키거나,(ⅳ) 일반식(Ⅰ)의 화합물의 염을 상이한 유기 또는 무기산으로 처리하여 약리학적으로 허용되는 산부가염으로 전환시키거나,(ⅴ) 일반식(Ⅰ)의 화합물을 염을 무기염기로 처리하여 일반식(Ⅰ)의 유리 폴리펩티드로 분해시키는 것이 특징인 상기 일반식(Ⅰ)을 가진 펩티드를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US218886 | 1980-12-22 | ||
| US06/218,886 US4320118A (en) | 1980-12-22 | 1980-12-22 | Deca-, undeca-, dodeca- and tridecapeptides with thymic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830007522A true KR830007522A (ko) | 1983-10-21 |
Family
ID=22816887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810004963A KR830007522A (ko) | 1980-12-22 | 1981-12-17 | 흉선(胸腺)활성을 가진 데카-운데카-도데카- 및 트리데카펩티드의 제조방법 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4320118A (ko) |
| EP (1) | EP0055113B1 (ko) |
| JP (1) | JPS57128666A (ko) |
| KR (1) | KR830007522A (ko) |
| AT (1) | ATE12778T1 (ko) |
| AU (1) | AU546769B2 (ko) |
| CA (1) | CA1187869A (ko) |
| DE (1) | DE3170055D1 (ko) |
| DK (1) | DK568281A (ko) |
| FI (1) | FI77046C (ko) |
| HU (1) | HU189550B (ko) |
| IE (1) | IE53004B1 (ko) |
| IL (1) | IL64610A (ko) |
| NO (1) | NO814384L (ko) |
| NZ (1) | NZ199335A (ko) |
| YU (1) | YU42752B (ko) |
| ZA (1) | ZA818829B (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4395404A (en) * | 1982-05-14 | 1983-07-26 | George Washington University | Synthetic thymosin β3 and β4 analogues |
| CS256897B1 (en) * | 1984-12-17 | 1988-04-15 | Evzen Kasafirek | Series thymic factor's analogue-type peptides |
| US4740588A (en) * | 1986-08-07 | 1988-04-26 | Washington University | Novel substrate peptides |
| NZ226557A (en) * | 1987-10-15 | 1990-07-26 | Syntex Inc | Pharmaceutical compositions for the intranasal administration of a biologically active polypeptide in powder form and process for their preparation |
| US5786327A (en) | 1993-03-12 | 1998-07-28 | Gensci Regeneration Sciences Inc. | Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same |
| US6352973B1 (en) | 1995-06-07 | 2002-03-05 | Osteopharm Inc. | Bone stimulating factor |
| US6693081B2 (en) * | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| DE19724793A1 (de) * | 1997-06-06 | 1998-12-10 | Schering Ag | D-mutierte Peptide mit VEGF-Rezeptor blockierenden Eigenschaften |
| WO1999025752A1 (en) * | 1997-11-18 | 1999-05-27 | Aventis Pharmaceuticals Products Inc. | Functionalized resin for the synthesis of amides and peptides |
| US6815421B1 (en) * | 2001-03-22 | 2004-11-09 | Osteopharm Inc. | Polypeptides for use in ameliorating effects of aging in mammals |
| GB2385415B (en) * | 2002-02-15 | 2005-09-14 | Teraview Ltd | An analysis apparatus and method |
| US20060052307A1 (en) * | 2002-12-05 | 2006-03-09 | Tam Cherk S | Bone growth factor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046877A (en) * | 1975-07-18 | 1977-09-06 | Syntex (U.S.A.) Inc. | Method of increasing immunologic competence |
-
1980
- 1980-12-22 US US06/218,886 patent/US4320118A/en not_active Expired - Fee Related
-
1981
- 1981-12-17 KR KR1019810004963A patent/KR830007522A/ko unknown
- 1981-12-21 YU YU3035/81A patent/YU42752B/xx unknown
- 1981-12-21 IE IE3004/81A patent/IE53004B1/en unknown
- 1981-12-21 FI FI814112A patent/FI77046C/fi not_active IP Right Cessation
- 1981-12-21 JP JP56205391A patent/JPS57128666A/ja active Pending
- 1981-12-21 DK DK568281A patent/DK568281A/da not_active Application Discontinuation
- 1981-12-21 NO NO814384A patent/NO814384L/no unknown
- 1981-12-21 CA CA000392786A patent/CA1187869A/en not_active Expired
- 1981-12-21 AT AT81305995T patent/ATE12778T1/de not_active IP Right Cessation
- 1981-12-21 ZA ZA818829A patent/ZA818829B/xx unknown
- 1981-12-21 AU AU78705/81A patent/AU546769B2/en not_active Ceased
- 1981-12-21 IL IL64610A patent/IL64610A/xx unknown
- 1981-12-21 HU HU813891A patent/HU189550B/hu unknown
- 1981-12-21 NZ NZ199335A patent/NZ199335A/en unknown
- 1981-12-21 DE DE8181305995T patent/DE3170055D1/de not_active Expired
- 1981-12-21 EP EP81305995A patent/EP0055113B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE53004B1 (en) | 1988-05-11 |
| YU42752B (en) | 1988-12-31 |
| CA1187869A (en) | 1985-05-28 |
| FI77046C (fi) | 1989-01-10 |
| NZ199335A (en) | 1985-05-31 |
| DK568281A (da) | 1982-06-23 |
| JPS57128666A (en) | 1982-08-10 |
| FI77046B (fi) | 1988-09-30 |
| EP0055113B1 (en) | 1985-04-17 |
| AU546769B2 (en) | 1985-09-19 |
| IL64610A (en) | 1985-08-30 |
| EP0055113A2 (en) | 1982-06-30 |
| YU303581A (en) | 1984-02-29 |
| IE813004L (en) | 1982-06-22 |
| IL64610A0 (en) | 1982-03-31 |
| FI814112L (fi) | 1982-06-23 |
| NO814384L (no) | 1982-06-23 |
| HU189550B (en) | 1986-07-28 |
| AU7870581A (en) | 1982-07-01 |
| EP0055113A3 (en) | 1982-08-11 |
| DE3170055D1 (en) | 1985-05-23 |
| US4320118A (en) | 1982-03-16 |
| ZA818829B (en) | 1983-07-27 |
| ATE12778T1 (de) | 1985-05-15 |
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