KR910000609A - 스페르구알린-관련된 화합물, 및 이의 제조방법 및 용도 - Google Patents

스페르구알린-관련된 화합물, 및 이의 제조방법 및 용도 Download PDF

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KR910000609A
KR910000609A KR1019890008621A KR890008621A KR910000609A KR 910000609 A KR910000609 A KR 910000609A KR 1019890008621 A KR1019890008621 A KR 1019890008621A KR 890008621 A KR890008621 A KR 890008621A KR 910000609 A KR910000609 A KR 910000609A
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South Korea
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hydrogen atom
pharmacologically acceptable
formula
group
related compounds
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KR1019890008621A
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KR0132778B1 (ko
Inventor
데쯔시 사이노
쯔기오 토미요시
큐이찌 네모또
요시하사 우메다
Original Assignee
사까노 쯔네가즈
니혼 가야꾸 가부시끼가이샤
다나베 아끼라
다까라 슈죠 가부시끼가이샤
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Publication of KR910000609A publication Critical patent/KR910000609A/ko
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Publication of KR0132778B1 publication Critical patent/KR0132778B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

스페르구알린-관련된 화합물, 및 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(I)의 스페르구알린-관련된 화합물 또는 이의 약리학적으로 허용되는 염.
    상기식에서, X는또는이고 Y는 수소원자 ; 또는 아미노산 또는 펩티드의 카복실 그룹으로부터 하이드록실 그룹을 제거하여 수득된 잔기이며, m은 0.1 또는 2이고, n은 1또는 2이며, 단, n이 2이고, m이 0일 경우, Y는 수소원자가 아니다.
  2. 제1항에 있어서, Y가 수소원자인 화합물 또는 이의 약리학적으로 허용되는 염.
  3. 제1항에 있어서, X가이고, Y가 수소원자이며, m 및 n이 각각 1인 화합물 또는 이의 약리학적으로 허용되는 염.
  4. 하기 구조식의 스페르구알린-관련된 화합물 또는 이의 약리학적으로 허용되는 염.
  5. 하기 구조식의 스페르구알린-관련된 화합물 또는 이의 약리학적으로 허용되는 염.
  6. 일반식(II)의 보호된 화합물로부터 보호그룹을 제거시킴을 특징으로 하여, 일반식(I)의 스페르구알린-관련된 화합물 또는 이의 약리학적으로 허용되는 염을 제조하는 방법.
    상기식에서, X는또는이고 Y는 수소원자 ; 또는 아미노산 또는 펩티드의 카복실 그룹으로부터 하이드록실 그룹을 제거하여 수득된 잔기이고, m은 0,1 또는 2이며, n은 1 또는 2이고, 단, n이 2이고, m이 0일 경우, Y는 수소원자가 아니며, R1은 아미노-보호그룹이고, R2는 아미노-보호그룹, 또는 보호된 아미노 그룹을 갖는 아미노산 또는 펩티드의 카복실 그룹으로부터 하이드록실 그룹을 제거하여 수득된 잔기(잔기의 측쇄가 보호될 수도 있다)이다.
  7. 활성성분으로서 일반식(I)의 스페르구알린-관련된 화합물 또는 이의 약리학적으로 허용되는 염을 함유하는 면역억제제.
    상기식에서, X는또는이고 Y는 수소원자 ; 또는 아미노산 또는 펩티드의 카복실 그룹으로부터 하이드록실 그룹을 제거하여 수득된 잔기이며, m은 0.1 또는 2이며, n은 1 또는 2이고, 단, n이 2이고, m이 0일 경우, Y는 수소원자가 아니다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890008621A 1988-06-24 1989-06-22 스페르구알린-관련된 화합물 및 이의 제조방법 및 용도 KR0132778B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-154590 1988-06-24
JP15459088 1988-06-24

Publications (2)

Publication Number Publication Date
KR910000609A true KR910000609A (ko) 1991-01-29
KR0132778B1 KR0132778B1 (ko) 1998-04-13

Family

ID=15587516

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890008621A KR0132778B1 (ko) 1988-06-24 1989-06-22 스페르구알린-관련된 화합물 및 이의 제조방법 및 용도

Country Status (5)

Country Link
US (1) US5061787A (ko)
EP (1) EP0347820B1 (ko)
JP (1) JPH02131458A (ko)
KR (1) KR0132778B1 (ko)
DE (1) DE68906086T2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0467280B1 (en) * 1990-07-20 1994-09-28 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compound and use thereof
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
FR2698628B1 (fr) * 1992-12-02 1995-02-17 Fournier Ind & Sante Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
ES2125714T3 (es) * 1995-02-10 1999-03-01 Fournier Ind & Sante Compuesto perteneciente a la familia de los analogos de la 15-deoxiespergualina.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法

Also Published As

Publication number Publication date
KR0132778B1 (ko) 1998-04-13
EP0347820B1 (en) 1993-04-21
EP0347820A1 (en) 1989-12-27
JPH02131458A (ja) 1990-05-21
US5061787A (en) 1991-10-29
DE68906086T2 (de) 1993-09-09
DE68906086D1 (de) 1993-05-27

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