KR830008996A - 펩티드 제조방법 - Google Patents
펩티드 제조방법 Download PDFInfo
- Publication number
- KR830008996A KR830008996A KR1019820000415A KR820000415A KR830008996A KR 830008996 A KR830008996 A KR 830008996A KR 1019820000415 A KR1019820000415 A KR 1019820000415A KR 820000415 A KR820000415 A KR 820000415A KR 830008996 A KR830008996 A KR 830008996A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- salt
- formula
- hydrogen
- carboxy
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 하기 구조식(1)의 화합물 혹은 그 염을 하기 구조식(2)의 화합물 혹은 그 염과 반응시켜서 하기 구조식(3)의 화합물 혹은 그 염을 제조하고, 이 화합물(3) 혹은 그 염을 보호기 제거반응에 가하여 하기 구조식(4)의 화합물 혹은 그 염을 제조하고, 이 화합물(4)의 아미노 보호기 제거의 화합물(4') 혹은 그 염을 탈아실화하여 하기 구조식(5)의 화합물 혹은 제약학적으로 알맞는 염을 제조하는 방법.t2상기 구조식에서R1은 수소 혹은 아실이고,R2는 저급알킬이고,R3는 카르복시 혹은 보호된 카르복시이고,R4는 수소 혹은 저급알킬이고,R5는 수소, 알킬 혹은 아르(저급)알킬이고,R6는 카르복시 혹은 보호된 카르복시이고,R7은 수소 혹은 보호된 아미노보호기이고,R3 a는 보호된 카르복시이고,Ra 6는 아미노 보호기임.
- 청구범위 1에 있어서의 활성성분 혹은 제약학적으로 알맞는 염으로 구성되는 제약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8102709 | 1981-01-29 | ||
GB8102709 | 1981-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR830008996A true KR830008996A (ko) | 1983-12-16 |
Family
ID=10519316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019820000415A KR830008996A (ko) | 1981-01-29 | 1982-01-29 | 펩티드 제조방법 |
Country Status (10)
Country | Link |
---|---|
US (1) | US4476050A (ko) |
EP (1) | EP0057419B1 (ko) |
JP (1) | JPH068315B2 (ko) |
KR (1) | KR830008996A (ko) |
AT (1) | ATE10934T1 (ko) |
AU (1) | AU7993982A (ko) |
DE (1) | DE3261643D1 (ko) |
DK (1) | DK34882A (ko) |
ES (1) | ES8304925A1 (ko) |
GR (1) | GR79114B (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6834194A (en) * | 1993-05-14 | 1994-12-12 | Mallinckrodt Medical, Inc. | Ligand precursors for incorporation into peptides |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1431724A (en) * | 1973-01-08 | 1976-04-14 | Tektronix Inc | System for acquiring processing and displaying information |
FR2442889A1 (fr) * | 1978-10-19 | 1980-06-27 | Anvar | Nouveaux composes hydrosolubles provenant d'extraits de streptomyces stimulosus, leur obtention, leur application a titre d'adjuvants immunologiques et compositions les contenant |
GB2033906B (en) * | 1978-10-19 | 1982-12-01 | Anvar | Water-soluble compounds derived from extracts of streptomyces stimulosus process for their production and compositions containing them |
US4311640A (en) * | 1978-11-14 | 1982-01-19 | Fujisawa Pharmaceutical Co., Ltd. | Peptide, process for preparation thereof and use thereof |
JPS5585552A (en) * | 1978-11-14 | 1980-06-27 | Fujisawa Pharmaceut Co Ltd | New lactyltetrapeptide |
EP0011283B1 (en) * | 1978-11-14 | 1982-07-28 | Fujisawa Pharmaceutical Co., Ltd. | New lactyl tetrapeptide, processes for preparation thereof and pharmaceutical compositions containing it |
FR2460290A1 (fr) * | 1979-06-29 | 1981-01-23 | Rhone Poulenc Ind | Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent |
FR2460289A1 (fr) * | 1979-06-29 | 1981-01-23 | Rhone Poulenc Ind | Nouveaux tripeptides, leur preparation et les medicaments qui les contiennent |
JPH0668024B2 (ja) * | 1986-07-15 | 1994-08-31 | 三井東圧化学株式会社 | 熱硬化性樹脂組成物 |
JPH0295413A (ja) * | 1988-09-30 | 1990-04-06 | Shibaura Eng Works Co Ltd | 酸素富化空気の水分除去装置 |
JPH0295412A (ja) * | 1988-09-30 | 1990-04-06 | Toyobo Co Ltd | 中空糸膜型気体分離膜装置 |
-
1982
- 1982-01-07 GR GR66949A patent/GR79114B/el unknown
- 1982-01-20 US US06/341,057 patent/US4476050A/en not_active Expired - Fee Related
- 1982-01-26 DK DK34882A patent/DK34882A/da not_active Application Discontinuation
- 1982-01-27 EP EP82100552A patent/EP0057419B1/en not_active Expired
- 1982-01-27 AT AT82100552T patent/ATE10934T1/de not_active IP Right Cessation
- 1982-01-27 DE DE8282100552T patent/DE3261643D1/de not_active Expired
- 1982-01-27 JP JP57012010A patent/JPH068315B2/ja not_active Expired - Lifetime
- 1982-01-28 ES ES509154A patent/ES8304925A1/es not_active Expired
- 1982-01-28 AU AU79939/82A patent/AU7993982A/en not_active Abandoned
- 1982-01-29 KR KR1019820000415A patent/KR830008996A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
JPS57140751A (en) | 1982-08-31 |
US4476050A (en) | 1984-10-09 |
AU7993982A (en) | 1982-08-05 |
DE3261643D1 (en) | 1985-02-07 |
ES509154A0 (es) | 1983-03-16 |
EP0057419B1 (en) | 1984-12-27 |
EP0057419A1 (en) | 1982-08-11 |
DK34882A (da) | 1982-07-30 |
JPH068315B2 (ja) | 1994-02-02 |
ES8304925A1 (es) | 1983-03-16 |
ATE10934T1 (de) | 1985-01-15 |
GR79114B (ko) | 1984-10-02 |
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