FR2455897A1 - Adjuvant du type acide gras pour favoriser l'absorption de substances pharmacologiquement actives par le rectum, composition de base pour administration rectale comprenant cet adjuvant et composition pharmaceutique comprenant cet adjuvant - Google Patents

Adjuvant du type acide gras pour favoriser l'absorption de substances pharmacologiquement actives par le rectum, composition de base pour administration rectale comprenant cet adjuvant et composition pharmaceutique comprenant cet adjuvant

Info

Publication number
FR2455897A1
FR2455897A1 FR8010267A FR8010267A FR2455897A1 FR 2455897 A1 FR2455897 A1 FR 2455897A1 FR 8010267 A FR8010267 A FR 8010267A FR 8010267 A FR8010267 A FR 8010267A FR 2455897 A1 FR2455897 A1 FR 2455897A1
Authority
FR
France
Prior art keywords
adjuvant
rectum
absorption
promoting
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8010267A
Other languages
English (en)
Other versions
FR2455897B1 (fr
Inventor
Kazuhiko Kitao
Ken-Ichi Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5769079A external-priority patent/JPS55149209A/ja
Priority claimed from JP55035128A external-priority patent/JPS5857407B2/ja
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Publication of FR2455897A1 publication Critical patent/FR2455897A1/fr
Application granted granted Critical
Publication of FR2455897B1 publication Critical patent/FR2455897B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/15—Suppositories

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LES ACIDES GRAS AYANT DE 8 A 14 ATOMES DE CARBONE, L'ACIDE LEUCINIQUE ET LEURS SELS NON TOXIQUES FAVORISENT L'ABSORPTION D'UNE SUBSTANCE PHARMACOLOGIQUEMENT ACTIVE PAR LE RECTUM DANS LE COURANT SANGUIN ET SONT CAPABLES D'AUGMENTER EFFICACEMENT LA CONCENTRATION DE CETTE SUBSTANCE ACTIVE DANS LE COURANT SANGUIN MEME QUAND CETTE SUBSTANCE ACTIVE N'EST HABITUELLEMENT ABSORBABLE PAR LE RECTUM QU'AVEC UNE DIFFICULTE CONSIDERABLE.
FR8010267A 1979-05-10 1980-05-08 Adjuvant du type acide gras pour favoriser l'absorption de substances pharmacologiquement actives par le rectum, composition de base pour administration rectale comprenant cet adjuvant et composition pharmaceutique comprenant cet adjuvant Granted FR2455897A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5769079A JPS55149209A (en) 1979-05-10 1979-05-10 Composition for rectal administration
JP55035128A JPS5857407B2 (ja) 1980-03-19 1980-03-19 直腸投与剤用基剤

Publications (2)

Publication Number Publication Date
FR2455897A1 true FR2455897A1 (fr) 1980-12-05
FR2455897B1 FR2455897B1 (fr) 1985-03-01

Family

ID=26374052

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8010267A Granted FR2455897A1 (fr) 1979-05-10 1980-05-08 Adjuvant du type acide gras pour favoriser l'absorption de substances pharmacologiquement actives par le rectum, composition de base pour administration rectale comprenant cet adjuvant et composition pharmaceutique comprenant cet adjuvant

Country Status (5)

Country Link
US (2) US4338306A (fr)
CA (1) CA1166964A (fr)
DE (1) DE3017829A1 (fr)
FR (1) FR2455897A1 (fr)
GB (1) GB2051574B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456522A1 (fr) * 1979-05-18 1980-12-12 Kao Corp Composition d'insuline, son procede de preparation et son application en therapeutique
FR2497669A1 (fr) * 1981-01-14 1982-07-16 Toyo Jozo Kk Preparation pharmaceutique ayant d'excellentes proprietes d'absorption
DE3200766A1 (de) * 1981-01-14 1982-09-16 Toyo Jozo Kk Praeparat mit ausgezeichneter absorptionseigenschaft
DE3207480A1 (de) * 1981-03-06 1982-10-07 Toyo Jozo Co., Ltd., Shizuoka Praeparat mit ausgezeichneten absorptionseigenschaften
EP0384283A2 (fr) * 1989-02-22 1990-08-29 VEB Berlin-Chemie Médicament pour application rectale et procédé pour sa préparation
EP0420056A2 (fr) * 1989-09-27 1991-04-03 Universiteit Gent Utilisation d'acides gras, de sels d'acides gras et d'esters d'acides gras et de mono-, di- ou trihydroxyalcanes
EP0533938A1 (fr) * 1991-02-19 1993-03-31 TSUMURA & CO. Composition pour administration par voie rectale de peptides difficiles a absorber
WO2018087298A1 (fr) * 2016-11-14 2018-05-17 University Of Copenhagen Insuline rectale pour le traitement de maladies intestinales inflammatoires

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GB2051574B (en) * 1979-05-10 1984-01-18 Kyoto Pharma Ind Adjuvant for promoting absorption of pharmacologically active substances through the rectum
US4442090A (en) * 1980-11-09 1984-04-10 Kyoto Yakuhin Kogyo Kabushiki Kaisha Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
CA1256799A (fr) * 1984-02-22 1989-07-04 Walter Fuller Suppositoires
IL72684A (en) * 1984-08-14 1989-02-28 Israel State Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs
US4874795A (en) * 1985-04-02 1989-10-17 Yesair David W Composition for delivery of orally administered drugs and other substances
CA1257199A (fr) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation contenant une substance macromoleculaire ayant des proprietes biologiques liberee pendant plusieurs mois in vivo
DK158598C (da) * 1988-07-07 1990-11-19 Pharma Vinci As Penicillinpraeparat til rektal administration
US5190748A (en) * 1988-11-22 1993-03-02 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
ES2089011T3 (es) * 1989-02-17 1996-10-01 Liposome Co Inc Excipiente lipidico de administracion nasal y aplicacion topica.
AU664719B2 (en) * 1991-11-08 1995-11-30 Green Cross Corporation, The Pharmaceutical preparation containing prostaglandin compound for rectal or vaginal administration
US5891435A (en) * 1993-04-16 1999-04-06 Research Corporation Technologies, Inc. Methods and compositions for delaying or preventing the onset of autoimmune disease
EP0800828A4 (fr) * 1994-12-28 1999-03-31 Teikoku Hormone Mfg Co Ltd Preparation traversant la muqueuse
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
KR20030005204A (ko) * 2000-12-25 2003-01-17 가부시키가이샤 시세이도 교감신경 활성화 향료 조성물
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
AT413015B (de) * 2001-04-12 2005-10-15 Sandoz Ag Tablette enthaltend das k-salz der 3-(2-hydroxyethyliden)-7-oxo-4-oxa-1- azabicyclo(3.2.0)heptan-2 carbonsäure in hydrophobisierter form
AU2002315287A1 (en) * 2001-04-12 2002-10-28 Sandoz Gmbh Pharmaceutical composition comprising clavulanic acid
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6585996B1 (en) 2002-03-13 2003-07-01 Westlake Laboratories, Inc. Lipid-soluble thiamine derivatives in the treatment of autism
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
AU2005329255B2 (en) * 2004-04-15 2010-09-30 Chiasma, Inc. Compositions capable of facilitating penetration across a biological barrier
EP2626368B1 (fr) 2004-07-19 2016-12-21 Biocon Limited Conjugués insuline-oligomère, formulations et utilisations de ceux-ci
KR101269540B1 (ko) * 2005-10-13 2013-05-30 바이오콘 리미티드 인슐린 접합체의 제조를 위한 방법
AU2008313248B2 (en) 2007-10-16 2012-04-26 Biocon Limited An orally administerable solid pharmaceutical composition and a process thereof
US20090271021A1 (en) * 2008-04-28 2009-10-29 Popp Shane M Execution system for the monitoring and execution of insulin manufacture
MX2011002836A (es) 2008-09-17 2011-04-28 Chiasma Inc Composiciones farmaceúticas y métodos de administración relacionados.
SI24318A (sl) * 2013-03-13 2014-09-30 Diagen D.O.O. Nove stabilne soli pentadekapeptida, postopek za njihovo pripravo, njihova uporaba za izdelavo farmacevtskih pripravkov in njihova uporaba v terapiji
MA41462A (fr) 2015-02-03 2021-05-12 Chiasma Inc Méthode de traitement de maladies
CA3052047A1 (fr) 2017-02-13 2018-08-16 Wintermute Biomedical, Inc. Compositions therapeutiques anti-pathogenes
CA3115050A1 (fr) 2018-10-01 2020-04-09 Wintermute Biomedical, Inc. Compositions therapeutiques
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL45481C (fr) * 1900-01-01
DE2700433A1 (de) * 1977-01-07 1978-07-20 Kali Chemie Pharma Gmbh Arzneimittelzubereitungen mit verbesserten resorptionseigenschaften
FR2381520A1 (fr) * 1977-02-28 1978-09-22 Yamanouchi Pharma Co Ltd Compositions pour usage rectal
NL7806048A (nl) * 1978-06-02 1979-12-04 Kali Chemie Pharma Gmbh Geneesmiddel met betere resorptie-eigenschappen en werkwijze voor de bereiding daarvan.

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US1499348A (en) * 1918-09-03 1924-07-01 Frederick D Crane Suppository and method of making the same
US2241331A (en) * 1939-01-27 1941-05-06 Wm S Merrell Co Suppository
US2870201A (en) * 1955-04-04 1959-01-20 Maxwell A Pollack Synthesis of amino acids
GB792559A (en) * 1955-07-12 1958-03-26 Glaxo Lab Ltd Improvements in or relating to the manufacture of veterinary preparations containing penicillin
US2854378A (en) * 1955-12-08 1958-09-30 Bristol Lab Inc Tetracycline suppository
DE1094930B (de) * 1959-04-24 1960-12-15 Dehydag Gmbh Verfahren zur Herstellung von Suppositorien
FR2853M (fr) * 1963-02-20 1964-10-19 Roussel Uclaf Nouveau médicament, notamment pour le traitement des infections dues a des staphylocoques.
DE2211619A1 (de) * 1972-03-07 1973-09-20 Mannesmann Meer Ag Untersetzungsgetriebe mit leistungsverzweigung, insbesondere fuer den kippantrieb von stahlwerkskonvertern
FR2272684A1 (en) * 1975-01-07 1975-12-26 Ito Shojiro Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria
JPS5391113A (en) * 1977-01-21 1978-08-10 Meiji Seika Kaisha Ltd Preparation of suppository of antibiotics
JPS6029535B2 (ja) * 1977-03-12 1985-07-11 ロ−ト製薬株式会社 塑性体成形組成物の製造法
US4331653A (en) * 1977-08-18 1982-05-25 Robert Brown Composition for a topical cream for curtailing bleeding and treating skin disorders
GB2051574B (en) * 1979-05-10 1984-01-18 Kyoto Pharma Ind Adjuvant for promoting absorption of pharmacologically active substances through the rectum

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL45481C (fr) * 1900-01-01
DE2700433A1 (de) * 1977-01-07 1978-07-20 Kali Chemie Pharma Gmbh Arzneimittelzubereitungen mit verbesserten resorptionseigenschaften
FR2381520A1 (fr) * 1977-02-28 1978-09-22 Yamanouchi Pharma Co Ltd Compositions pour usage rectal
NL7806048A (nl) * 1978-06-02 1979-12-04 Kali Chemie Pharma Gmbh Geneesmiddel met betere resorptie-eigenschappen en werkwijze voor de bereiding daarvan.

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456522A1 (fr) * 1979-05-18 1980-12-12 Kao Corp Composition d'insuline, son procede de preparation et son application en therapeutique
FR2497669A1 (fr) * 1981-01-14 1982-07-16 Toyo Jozo Kk Preparation pharmaceutique ayant d'excellentes proprietes d'absorption
DE3200766A1 (de) * 1981-01-14 1982-09-16 Toyo Jozo Kk Praeparat mit ausgezeichneter absorptionseigenschaft
DE3207480A1 (de) * 1981-03-06 1982-10-07 Toyo Jozo Co., Ltd., Shizuoka Praeparat mit ausgezeichneten absorptionseigenschaften
EP0384283A2 (fr) * 1989-02-22 1990-08-29 VEB Berlin-Chemie Médicament pour application rectale et procédé pour sa préparation
EP0384283A3 (fr) * 1989-02-22 1991-07-17 VEB Berlin-Chemie Médicament pour application rectale et procédé pour sa préparation
EP0420056A2 (fr) * 1989-09-27 1991-04-03 Universiteit Gent Utilisation d'acides gras, de sels d'acides gras et d'esters d'acides gras et de mono-, di- ou trihydroxyalcanes
EP0420056A3 (en) * 1989-09-27 1991-08-28 N.V. Vandemoortele International Use of fatty acids, fatty acid salts and fatty acid esters of mono-, di- or trihydroxy alkanes or their derivatives
EP0533938A1 (fr) * 1991-02-19 1993-03-31 TSUMURA & CO. Composition pour administration par voie rectale de peptides difficiles a absorber
EP0533938A4 (en) * 1991-02-19 1993-06-16 Tsumura & Co. Composition for rectal administration of difficultly absorbable peptide
WO2018087298A1 (fr) * 2016-11-14 2018-05-17 University Of Copenhagen Insuline rectale pour le traitement de maladies intestinales inflammatoires
US11400137B2 (en) 2016-11-14 2022-08-02 University Of Copenhagen Rectal insulin for treatment of inflammatory bowel diseases

Also Published As

Publication number Publication date
US4338306A (en) 1982-07-06
CA1166964A (fr) 1984-05-08
US4485033A (en) 1984-11-27
GB2051574B (en) 1984-01-18
GB2051574A (en) 1981-01-21
FR2455897B1 (fr) 1985-03-01
DE3017829C2 (fr) 1988-07-07
DE3017829A1 (de) 1980-11-20

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