FR2451370A1 - Derives hydroxyles de l'isopropylamino-2 pyrimidine et leur preparation - Google Patents
Derives hydroxyles de l'isopropylamino-2 pyrimidine et leur preparationInfo
- Publication number
- FR2451370A1 FR2451370A1 FR8005278A FR8005278A FR2451370A1 FR 2451370 A1 FR2451370 A1 FR 2451370A1 FR 8005278 A FR8005278 A FR 8005278A FR 8005278 A FR8005278 A FR 8005278A FR 2451370 A1 FR2451370 A1 FR 2451370A1
- Authority
- FR
- France
- Prior art keywords
- pyrimidine
- isopropylamino
- preparation
- hydroxyl derivatives
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES DERIVES HYDROXYLES DE L'ISOPROPYLAMINO-2 PYRIMIDINE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE A, A ET A REPRESENTENT CHACUN: -UN ATOME D'HYDROGENE, UN RADICAL HYDROXY, AVEC LA RESTRICTION QU'AU MOINS L'UN DES SUBSTITUANTS A, A ET A N'EST PAS UN ATOME D'HYDROGENE, AINSI QU'UN PROCEDE DE PREPARATION DES DERIVES SELON LA REVENDICATION 1, CONSISTANT A FAIRE REAGIR LA THIOMETHYLE-2 PYRIMIDINE CORRESPONDANTE SUR L'ISOPROPYLAMINE DANS UN SOLVANT NON POLAIRE A LA TEMPERATURE DE 100-120C, SOUS PRESSION, SELON LE SCHEMA SUIVANT:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7908494 | 1979-03-10 | ||
GB7914987 | 1979-04-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2451370A1 true FR2451370A1 (fr) | 1980-10-10 |
FR2451370B1 FR2451370B1 (fr) | 1983-05-13 |
Family
ID=26270867
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8005278A Granted FR2451370A1 (fr) | 1979-03-10 | 1980-03-10 | Derives hydroxyles de l'isopropylamino-2 pyrimidine et leur preparation |
FR8005277A Granted FR2451191A1 (fr) | 1979-03-10 | 1980-03-10 | Compositions therapeutiques a base de derives hydroxyles de l'isopropylamino-2 pyrimidine |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8005277A Granted FR2451191A1 (fr) | 1979-03-10 | 1980-03-10 | Compositions therapeutiques a base de derives hydroxyles de l'isopropylamino-2 pyrimidine |
Country Status (24)
Country | Link |
---|---|
JP (1) | JPS55122768A (fr) |
AR (1) | AR222691A1 (fr) |
AU (1) | AU533547B2 (fr) |
BE (1) | BE881752A (fr) |
CA (1) | CA1132561A (fr) |
CH (1) | CH644368A5 (fr) |
DE (3) | DE3009071C2 (fr) |
EG (1) | EG14282A (fr) |
FI (1) | FI66357C (fr) |
FR (2) | FR2451370A1 (fr) |
GB (1) | GB2045756B (fr) |
HK (1) | HK55383A (fr) |
IE (1) | IE49547B1 (fr) |
IN (1) | IN153791B (fr) |
LU (1) | LU82185A1 (fr) |
MX (1) | MX6218E (fr) |
MY (1) | MY8400200A (fr) |
NL (1) | NL184833C (fr) |
NO (1) | NO154054C (fr) |
NZ (1) | NZ192927A (fr) |
OA (1) | OA06484A (fr) |
PT (1) | PT70882A (fr) |
SE (1) | SE435180B (fr) |
SG (1) | SG22683G (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE894517A (fr) * | 1981-10-16 | 1983-01-17 | Sod Conseils Rech Applic | Nouveau derive de l'isopropylamino pyrimidine, sa preparation et composition therapeutiques a base de ses composes |
US4673677A (en) * | 1983-10-03 | 1987-06-16 | Pfizer Inc. | Method for treatment of gastrointestinal disorders |
US4554276A (en) * | 1983-10-03 | 1985-11-19 | Pfizer Inc. | 2-Amino-5-hydroxy-4-methylpyrimidine derivatives |
US4711888A (en) | 1985-07-24 | 1987-12-08 | Pfizer Inc. | Hydroxy and alkoxy pyrimidines |
WO1989000423A1 (fr) * | 1987-07-09 | 1989-01-26 | Pfizer Inc. | 2-amino-5-hydroxy-4-pyrimidones |
US4910204A (en) * | 1988-06-28 | 1990-03-20 | Pfizer Inc. | 2-amino-5-hydroxy-4-pyrimidones |
US5264435A (en) * | 1988-12-29 | 1993-11-23 | Mitsui Petrochemical Industries, Ltd. | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines |
HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
US4940712A (en) * | 1989-05-26 | 1990-07-10 | Pfizer Inc. | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors |
US5270319A (en) * | 1991-09-09 | 1993-12-14 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents |
US5220025A (en) * | 1992-02-24 | 1993-06-15 | Warner-Lambert Company | 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
US5196431A (en) * | 1992-02-24 | 1993-03-23 | Warner-Lambert Company | 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
US9133212B1 (en) * | 2005-06-15 | 2015-09-15 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB741667A (en) * | 1952-12-05 | 1955-12-07 | Ici Ltd | New pyrimidine derivatives |
GB756189A (en) * | 1954-02-01 | 1956-08-29 | Ici Ltd | New pyrimidine derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA711152B (en) * | 1970-03-02 | 1971-11-24 | Ici Ltd | Manufacture of pyrimidines |
GB1525995A (en) * | 1976-02-18 | 1978-09-27 | Soc D Etudes Prod Chimique | Aminopyrimidine salt |
-
1980
- 1980-02-12 IN IN103/DEL/80A patent/IN153791B/en unknown
- 1980-02-15 BE BE0/199421A patent/BE881752A/fr not_active IP Right Cessation
- 1980-02-20 NZ NZ192927A patent/NZ192927A/xx unknown
- 1980-02-20 LU LU82185A patent/LU82185A1/fr unknown
- 1980-02-26 FI FI800566A patent/FI66357C/fi not_active IP Right Cessation
- 1980-02-27 AR AR280106A patent/AR222691A1/es active
- 1980-02-29 PT PT70882A patent/PT70882A/pt unknown
- 1980-03-03 CH CH165080A patent/CH644368A5/fr not_active IP Right Cessation
- 1980-03-04 CA CA346,981A patent/CA1132561A/fr not_active Expired
- 1980-03-04 NL NLAANVRAGE8001289,A patent/NL184833C/xx not_active IP Right Cessation
- 1980-03-07 NO NO800664A patent/NO154054C/no unknown
- 1980-03-07 AU AU56248/80A patent/AU533547B2/en not_active Ceased
- 1980-03-07 IE IE477/80A patent/IE49547B1/en unknown
- 1980-03-07 SE SE8001812A patent/SE435180B/sv not_active IP Right Cessation
- 1980-03-07 GB GB8007908A patent/GB2045756B/en not_active Expired
- 1980-03-09 EG EG131/80A patent/EG14282A/xx active
- 1980-03-10 OA OA57049A patent/OA06484A/fr unknown
- 1980-03-10 FR FR8005278A patent/FR2451370A1/fr active Granted
- 1980-03-10 JP JP2931280A patent/JPS55122768A/ja active Granted
- 1980-03-10 DE DE3009071A patent/DE3009071C2/de not_active Expired
- 1980-03-10 MX MX808702U patent/MX6218E/es unknown
- 1980-03-10 FR FR8005277A patent/FR2451191A1/fr active Granted
- 1980-03-10 DE DE3050999A patent/DE3050999C2/de not_active Expired
- 1980-04-30 DE DE19803016752 patent/DE3016752A1/de active Granted
-
1983
- 1983-04-28 SG SG226/83A patent/SG22683G/en unknown
- 1983-11-17 HK HK553/83A patent/HK55383A/xx unknown
-
1984
- 1984-12-30 MY MY200/84A patent/MY8400200A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB741667A (en) * | 1952-12-05 | 1955-12-07 | Ici Ltd | New pyrimidine derivatives |
GB756189A (en) * | 1954-02-01 | 1956-08-29 | Ici Ltd | New pyrimidine derivatives |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |