GB756189A - New pyrimidine derivatives - Google Patents

New pyrimidine derivatives

Info

Publication number
GB756189A
GB756189A GB290654A GB290654A GB756189A GB 756189 A GB756189 A GB 756189A GB 290654 A GB290654 A GB 290654A GB 290654 A GB290654 A GB 290654A GB 756189 A GB756189 A GB 756189A
Authority
GB
United Kingdom
Prior art keywords
dihydroxy
hydroxy
hydroxyl
amino
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB290654A
Inventor
Roy Hull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB290654A priority Critical patent/GB756189A/en
Publication of GB756189A publication Critical patent/GB756189A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises (1) pyrimidyl sulphuric esters of the formula <FORM:0756189/IV(a)/1> and (2) the production of 5-hydroxy-pyrimidines by hydrolysis of the above esters; R1 is hydroxyl or -NAB where A and B are hydrogen or hydrocarbon radicals (which may form a ring with the N atom), R2 is amino, hydroxyl or alkyl and R3 is hydrogen, hydroxyl or alkyl. The sulphuric esters are made by treating the corresponding R1, R2, R3-substituted pyrimidines with a water-soluble persulphate, e.g. ammonium persulphate. Hydrolysis to the hydroxy compound is effected with an aqueous mineral acid. Examples show the production of the following substituted pyrimidines and their sulphuric esters: 4 : 5-dihydroxy-6-methyl - 2 - piperidino, 2 - amino - 4 : 5-dihydroxy - 6 - methyl, 2 : 4 - diamino - 5-hydroxy - 6 - methyl, 2 : 5 - dihydroxy - 4 : 6-dimethyl, 2 : 4 - diamino - 5 - hydroxy and 2-amino-4 : 5-dihydroxy.
GB290654A 1954-02-01 1954-02-01 New pyrimidine derivatives Expired GB756189A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB290654A GB756189A (en) 1954-02-01 1954-02-01 New pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB290654A GB756189A (en) 1954-02-01 1954-02-01 New pyrimidine derivatives

Publications (1)

Publication Number Publication Date
GB756189A true GB756189A (en) 1956-08-29

Family

ID=9748283

Family Applications (1)

Application Number Title Priority Date Filing Date
GB290654A Expired GB756189A (en) 1954-02-01 1954-02-01 New pyrimidine derivatives

Country Status (1)

Country Link
GB (1) GB756189A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3041338A (en) * 1958-07-21 1962-06-26 Nalco Chemical Co 5-hydroxy substituted tetrahydro-pyrimidines
FR2451191A1 (en) * 1979-03-10 1980-10-10 Ugine Kuhlmann THERAPEUTIC COMPOSITIONS BASED ON HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE
EP0303348A1 (en) 1987-07-09 1989-02-15 Pfizer Inc. 2-Amino-5-hydroxy-4-pyrimidones
US4910204A (en) * 1988-06-28 1990-03-20 Pfizer Inc. 2-amino-5-hydroxy-4-pyrimidones

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3041338A (en) * 1958-07-21 1962-06-26 Nalco Chemical Co 5-hydroxy substituted tetrahydro-pyrimidines
FR2451191A1 (en) * 1979-03-10 1980-10-10 Ugine Kuhlmann THERAPEUTIC COMPOSITIONS BASED ON HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE
FR2451370A1 (en) * 1979-03-10 1980-10-10 Ugine Kuhlmann HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE AND THEIR PREPARATION
EP0303348A1 (en) 1987-07-09 1989-02-15 Pfizer Inc. 2-Amino-5-hydroxy-4-pyrimidones
US4910204A (en) * 1988-06-28 1990-03-20 Pfizer Inc. 2-amino-5-hydroxy-4-pyrimidones

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