GB713259A - Improvements in or relating to processes for making derivatives of purine - Google Patents

Improvements in or relating to processes for making derivatives of purine

Info

Publication number
GB713259A
GB713259A GB1409151A GB1409151A GB713259A GB 713259 A GB713259 A GB 713259A GB 1409151 A GB1409151 A GB 1409151A GB 1409151 A GB1409151 A GB 1409151A GB 713259 A GB713259 A GB 713259A
Authority
GB
United Kingdom
Prior art keywords
alkyl
purine
relating
processes
hydrazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1409151A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB1409151A priority Critical patent/GB713259A/en
Publication of GB713259A publication Critical patent/GB713259A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises purine derivatives of the formula <FORM:0713259/IV (b)/1> where R1 is hydrogen or alkyl, R2 is alkyl, substituted alkyl, aryl or substituted aryl, or -NR1R2 is hydrazino or a heterocyclic system such as pyrrolidino, piperidino or morpholino; also salts thereof. These are made by alkylating 6 - mercaptopurine (see Specification 713,286), e.g. with dimethyl sulphate or methyl iodide, and reacting the resulting 6-alkylmercaptopurine with HNR1R2. Examples show the production of 6-dimethylamino-, 6-ethylamino-, 6-n-butylamino-, 6-anilino, 6-p-chloranilino, 6 - hydrazino, 6 - b - aminoethylamino-, 6 - morpholino, 6 - methylamino - and 6-diethylaminopurines. The preparation of 6-mercaptopurine (from hypoxanthine and phosphorus pentasulphide) and 6-methylmercaptopurine is also described.
GB1409151A 1951-06-14 1951-06-14 Improvements in or relating to processes for making derivatives of purine Expired GB713259A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1409151A GB713259A (en) 1951-06-14 1951-06-14 Improvements in or relating to processes for making derivatives of purine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1409151A GB713259A (en) 1951-06-14 1951-06-14 Improvements in or relating to processes for making derivatives of purine

Publications (1)

Publication Number Publication Date
GB713259A true GB713259A (en) 1954-08-11

Family

ID=10034825

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1409151A Expired GB713259A (en) 1951-06-14 1951-06-14 Improvements in or relating to processes for making derivatives of purine

Country Status (1)

Country Link
GB (1) GB713259A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844576A (en) * 1955-11-22 1958-07-22 American Cyanamid Co Preparation of purines
US2875203A (en) * 1958-03-03 1959-02-24 Shive William Alkylthiopurines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844576A (en) * 1955-11-22 1958-07-22 American Cyanamid Co Preparation of purines
US2875203A (en) * 1958-03-03 1959-02-24 Shive William Alkylthiopurines

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