GB845823A - Stabilised compositions comprising therapeutic imine derivatives and the preparation thereof - Google Patents

Stabilised compositions comprising therapeutic imine derivatives and the preparation thereof

Info

Publication number
GB845823A
GB845823A GB29807/58A GB2980758A GB845823A GB 845823 A GB845823 A GB 845823A GB 29807/58 A GB29807/58 A GB 29807/58A GB 2980758 A GB2980758 A GB 2980758A GB 845823 A GB845823 A GB 845823A
Authority
GB
United Kingdom
Prior art keywords
polyethylene glycol
preparation
tetramide
tetraethylene
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29807/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of GB845823A publication Critical patent/GB845823A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

Therapeutic compositions comprise anhydrous polyethylene glycol and a water soluble ethylene imine derivative of general formula: <FORM:0845823/VI/1> wherein n is 2 or 3 and R is trivalent radical of the formula \sY P = O; \sY P = S or <FORM:0845823/VI/2> and where n is 2, the remaining valency of R is by a radical having no substantial deletrious affect on the pharmacological properties and water solubility of the compound, e.g. diethylamine, morpholino, or radicals having the structures <FORM:0845823/VI/3> Specified and preferred derivatives are; N,N1, N11- triethylene thiophosphoramide; N, N1, N11 -triethylene phosphoramide; N, N -diethyl-N,1 N11-diethylenephosphoramide; N, N1 -diethylene -N11 -morpholinothiophosphoramide; 1,3,5, -triethyleneimine- 2,4,6-triazine, 0, 01 -pphenylene- N,N1,N11,N111-tetraethylene tetramide di(thio)phosphate and O, O1-p-phenylene-N, N1, N11, N111-tetraethylene tetramide diphosphate. The compositions preferably contain from 1 to 5% by weight of the ethylene imine derivative which maybe dissolved in the polyethylene glycol with or without the aid of heat and the resulting solutions may be sealed into ampoules or used in the preparation of tablets and ointments. The polyethylene glycol may have a molecular weight of from 200 to 6000 and may be a liquid; e.g. polyethylene glycol 400 or a solid, e.g. "Carbowax 4000".
GB29807/58A 1957-09-19 1958-09-17 Stabilised compositions comprising therapeutic imine derivatives and the preparation thereof Expired GB845823A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP845823X 1957-09-19

Publications (1)

Publication Number Publication Date
GB845823A true GB845823A (en) 1960-08-24

Family

ID=13834654

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29807/58A Expired GB845823A (en) 1957-09-19 1958-09-17 Stabilised compositions comprising therapeutic imine derivatives and the preparation thereof

Country Status (2)

Country Link
DE (1) DE1227613B (en)
GB (1) GB845823A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656211A1 (en) * 1993-11-09 1995-06-07 American Cyanamid Company Stable lyophilized thiotepa composition

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1196284A (en) * 1982-05-28 1985-11-05 Joshua Oduro-Yeboah Pharmaceutical formulations
EP0419890A3 (en) * 1989-09-29 1991-05-29 American Cyanamid Company Stable pharmaceutical formulations for antineoplastic compounds having more than one ethyleneimine group, and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656211A1 (en) * 1993-11-09 1995-06-07 American Cyanamid Company Stable lyophilized thiotepa composition

Also Published As

Publication number Publication date
DE1227613B (en) 1966-10-27

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