ES359831A1 - Substituted thiazolo-pyrimidines - Google Patents

Substituted thiazolo-pyrimidines

Info

Publication number
ES359831A1
ES359831A1 ES359831A ES359831A ES359831A1 ES 359831 A1 ES359831 A1 ES 359831A1 ES 359831 A ES359831 A ES 359831A ES 359831 A ES359831 A ES 359831A ES 359831 A1 ES359831 A1 ES 359831A1
Authority
ES
Spain
Prior art keywords
denotes
formula
products
chlorine
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES359831A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES359831A1 publication Critical patent/ES359831A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention comprises thiazolo-pyrimidines of either of the formul[mu] in which R denotes a hydrogen atom or a phenyl radical, R 1 denotes a hydrogen, chlorine or fluorine atom, an alkoxy group of 1-4 carbon atoms or a phenyl radical, X denotes a hydrogen or chlorine atom or a trifluoromethyl group, A denotes a hydrogen atom, B denotes a hydroxy group, or A and B together denote a C-C bond, provided that, when X denotes chlorine, R 1 denotes chlorine also, and when X denotes a trifluoromethyl radical, R 1 denotes hydrogen. The compounds of the first formula are prepared by reacting a compound of the formula in which X 1 denotes a bromine or chlorine atom, with propylenethiourea of the formula The products of the second formula are prepared by dehydrating the products of the first formula by treatment with a strong mineral acid. The invention extends to the salts of the products with acids and also to the tautomeric equivalents of products of the first formula, these tautomers being assigned the formula Examples are given. The products have medicinal uses (see Division A5).
ES359831A 1967-11-03 1968-11-02 Substituted thiazolo-pyrimidines Expired ES359831A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68030767A 1967-11-03 1967-11-03
US74185668A 1968-07-02 1968-07-02

Publications (1)

Publication Number Publication Date
ES359831A1 true ES359831A1 (en) 1970-10-01

Family

ID=27102429

Family Applications (1)

Application Number Title Priority Date Filing Date
ES359831A Expired ES359831A1 (en) 1967-11-03 1968-11-02 Substituted thiazolo-pyrimidines

Country Status (7)

Country Link
BE (1) BE723289A (en)
CH (2) CH498140A (en)
DE (1) DE1805948A1 (en)
ES (1) ES359831A1 (en)
FR (2) FR1595659A (en)
GB (1) GB1220896A (en)
SE (1) SE352088B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2195426B1 (en) * 1972-08-09 1975-10-17 Lipha

Also Published As

Publication number Publication date
FR8194M (en) 1970-09-07
SE352088B (en) 1972-12-18
CH498139A (en) 1970-10-31
DE1805948A1 (en) 1969-06-26
GB1220896A (en) 1971-01-27
BE723289A (en) 1969-04-30
FR1595659A (en) 1970-06-15
CH498140A (en) 1970-10-31

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