FR2437401A1 - Analogues cycliques de la callidine et leur application therapeutique - Google Patents

Analogues cycliques de la callidine et leur application therapeutique

Info

Publication number
FR2437401A1
FR2437401A1 FR7924399A FR7924399A FR2437401A1 FR 2437401 A1 FR2437401 A1 FR 2437401A1 FR 7924399 A FR7924399 A FR 7924399A FR 7924399 A FR7924399 A FR 7924399A FR 2437401 A1 FR2437401 A1 FR 2437401A1
Authority
FR
France
Prior art keywords
callidine
remainder
cyclic
arginine
glycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7924399A
Other languages
English (en)
Other versions
FR2437401B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST ORGANICHESKOGO SINTEZA AK
Original Assignee
INST ORGANICHESKOGO SINTEZA AK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST ORGANICHESKOGO SINTEZA AK filed Critical INST ORGANICHESKOGO SINTEZA AK
Publication of FR2437401A1 publication Critical patent/FR2437401A1/fr
Application granted granted Critical
Publication of FR2437401B1 publication Critical patent/FR2437401B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Abstract

LA PRESENTE INVENTION CONCERNE LA BIOCHIMIE, ET PLUS PRECISEMENT DE NOUVEAUX ANALOGUES CYCLIQUES DE LA CALLIDINE. CONFORMEMENT A L'INVENTION, LES ANALOGUES CYCLIQUES DE LA CALLIDINE REPONDENT A LA FORMULE GENERALE SUIVANTE: (CF DESSIN DANS BOPI) DANS LAQUELLE PRO EST UN RESTE DE LA L-PROLINE; GLY DE LA GLYCINE; PHE DE LA L-PHENYLALANINE; ARG DE LA L-ARGININE; R EST UN RESTE D'UN ACIDE A- OU O-AMINE OU D'UN PEPTIDE; R EST UN RESTE D'UN ACIDE A- OU O-AMINE; R EST LA L-SERINE OU LA GLYCINE; LE GROUPE CARBONYLE DE L'ARGININE ETANT LIE SOIT AVEC R, SOIT AVEC R PAR UNE LIAISON PEPTIDIQUE COVALENTE, ET LE CYCLE ETANT FORME EN UTILISANT LE GROUPE O-AMINO DE L'ACIDE AMINE EN POSITION 1 OU 2 DE LA SEQUENCE DE LA CALLIDINE. LES NOUVEAUX COMPOSES PROPOSES SONT DOTES D'UNE ACTIVITE BIOLOGIQUE ET PEUVENT TROUVER UNE APPLICATION DANS LA MEDECINE EN QUALITE DE SUBSTANCE ACTIVE DE PRODUITS MEDICAMENTEUX A ACTION HYPOTENSIVE PROLONGEE.
FR7924399A 1978-09-29 1979-10-01 Analogues cycliques de la callidine et leur application therapeutique Granted FR2437401A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU782699155A SU1219587A1 (ru) 1978-09-29 1978-09-29 Циклические аналоги каллидина и других пахикининов,обладающие пролонгированным гипотензивным действием в сочетании с низкой или полностью отсутствующей миотропной активностью

Publications (2)

Publication Number Publication Date
FR2437401A1 true FR2437401A1 (fr) 1980-04-25
FR2437401B1 FR2437401B1 (fr) 1983-11-18

Family

ID=20799586

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7924399A Granted FR2437401A1 (fr) 1978-09-29 1979-10-01 Analogues cycliques de la callidine et leur application therapeutique

Country Status (7)

Country Link
US (1) US4285857A (fr)
JP (1) JPS5573645A (fr)
BE (1) BE879088A (fr)
DE (1) DE2939522C2 (fr)
FR (1) FR2437401A1 (fr)
GB (1) GB2033397B (fr)
SU (1) SU1219587A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374060A (en) * 1981-07-15 1983-02-15 Merck & Co., Inc. Process for the preparation of cyclic hexapeptide
JPS6160699A (ja) * 1984-08-31 1986-03-28 Agency Of Ind Science & Technol 新規環状オクタペプチド，その製造方法及びそれを成分とする金属イオン抽出分離剤
ES2054011T3 (es) * 1988-09-05 1994-08-01 Sankyo Co Un proceso para la preparacion de un compuesto, "leualacina".

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889M (fr) * 1962-04-25 1964-11-02 Olin Mathieson Nouveau décapeptide désigné sous le nom de 7-glycine kallidine.
FR2411828A1 (fr) * 1977-12-14 1979-07-13 Inst Organicheskogo Sinteza Ak Analogue cyclique de la bradykinine, constitue par la cyclo- ((ne-1-llysine, 6-glycine)-bradykinine)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247181A (en) * 1960-09-01 1966-04-19 Ciba Geigy Corp Polypeptide derivatives and esters thereof
US3216992A (en) * 1962-04-16 1965-11-09 Olin Mathieson 7-glycine bradykinin and intermediates for the production thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889M (fr) * 1962-04-25 1964-11-02 Olin Mathieson Nouveau décapeptide désigné sous le nom de 7-glycine kallidine.
FR2411828A1 (fr) * 1977-12-14 1979-07-13 Inst Organicheskogo Sinteza Ak Analogue cyclique de la bradykinine, constitue par la cyclo- ((ne-1-llysine, 6-glycine)-bradykinine)

Also Published As

Publication number Publication date
JPS5573645A (en) 1980-06-03
GB2033397A (en) 1980-05-21
GB2033397B (en) 1982-11-03
FR2437401B1 (fr) 1983-11-18
US4285857A (en) 1981-08-25
SU1219587A1 (ru) 1986-03-23
BE879088A (fr) 1980-03-28
DE2939522C2 (de) 1982-03-18
DE2939522A1 (de) 1980-04-17

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Legal Events

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