FR2414503A1 - Nouveaux carboxamides n-(tetrazol-5-yliques) de prostaglandine et medicament les contenant - Google Patents

Nouveaux carboxamides n-(tetrazol-5-yliques) de prostaglandine et medicament les contenant

Info

Publication number
FR2414503A1
FR2414503A1 FR7900857A FR7900857A FR2414503A1 FR 2414503 A1 FR2414503 A1 FR 2414503A1 FR 7900857 A FR7900857 A FR 7900857A FR 7900857 A FR7900857 A FR 7900857A FR 2414503 A1 FR2414503 A1 FR 2414503A1
Authority
FR
France
Prior art keywords
class
carboxamides
tetrazol
atom
prostaglandins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7900857A
Other languages
English (en)
Other versions
FR2414503B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2414503A1 publication Critical patent/FR2414503A1/fr
Application granted granted Critical
Publication of FR2414503B1 publication Critical patent/FR2414503B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom

Abstract

L'invention concerne de nouveaux carboxamides N-(tétrazol-5-yliques) de prostaglandines. Les composés de l'invention entrent dans trois classes de carboxamides N-(tétrazol-5-yliques) de prostaglandines dont les substitutions de la chaîne latérale inferieure consistent en un groupe phényle ou phényle substitué sur l'atome C-16 (classe 1), phénoxy ou phénoxy substitué sur l'atome C-16 (classe 2) et n-pentyle, 2-hexyle ou 2-méthyl-2-hexyle sur l'atome C-15 (classe 3); la synthèse de ces composés a été effectuée en utilisant des composés intermédiaires imidazoliques acylés et le 5-aminotétrazole. Les trois classes de prostaglandines de l'invention ont des activités biologiques sélectives différentes, à savoir une activité anti-ulcéreuse (classe 1), une activité anticonceptionnelle (classe 2) et une activité bronchodilatatrice et anticonceptionnelle (classe 3).
FR7900857A 1978-01-16 1979-01-15 Nouveaux carboxamides n-(tetrazol-5-yliques) de prostaglandine et medicament les contenant Granted FR2414503A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86956978A 1978-01-16 1978-01-16
US89373178A 1978-04-05 1978-04-05

Publications (2)

Publication Number Publication Date
FR2414503A1 true FR2414503A1 (fr) 1979-08-10
FR2414503B1 FR2414503B1 (fr) 1981-12-24

Family

ID=27128123

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7900857A Granted FR2414503A1 (fr) 1978-01-16 1979-01-15 Nouveaux carboxamides n-(tetrazol-5-yliques) de prostaglandine et medicament les contenant

Country Status (28)

Country Link
JP (1) JPS54100378A (fr)
AR (1) AR222817A1 (fr)
AT (1) AT367755B (fr)
AU (1) AU507853B2 (fr)
CA (1) CA1152502A (fr)
CH (1) CH635833A5 (fr)
DD (1) DD141155A5 (fr)
DE (1) DE2901476C3 (fr)
DK (1) DK523378A (fr)
ES (1) ES482421A1 (fr)
FI (1) FI790120A (fr)
FR (1) FR2414503A1 (fr)
GB (1) GB2012272B (fr)
GR (1) GR72747B (fr)
IE (1) IE48175B1 (fr)
IL (1) IL56433A (fr)
IN (1) IN150279B (fr)
IT (1) IT1110992B (fr)
LU (1) LU80789A1 (fr)
NL (1) NL7900292A (fr)
NO (1) NO790122L (fr)
NZ (1) NZ189377A (fr)
PH (3) PH15031A (fr)
PL (1) PL117869B1 (fr)
PT (1) PT69076A (fr)
SE (1) SE427657B (fr)
SU (1) SU831071A3 (fr)
YU (1) YU4579A (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2316924A1 (fr) * 1975-06-23 1977-02-04 Pfizer 11-desoxy-16-aryloxy-o-tetranorprostaglandines
FR2394539A1 (fr) * 1977-06-13 1979-01-12 Pfizer Nouveaux derives substitues en position 15 d'o-pentanorprostaglandine et leur utilisation comme medicament

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788209A (fr) * 1971-09-01 1973-02-28 Pfizer Derives tetrazoyliques des prostaglandines naturelles
DD118856A5 (fr) * 1972-11-08 1976-03-20
DE2559093C3 (de) * 1975-12-30 1981-12-24 Pfizer Inc., 10017 New York, N.Y. 2-Desarboxy-2-[tetrazol-5-yl]-11-desoxy-ω-pentanorprostaglandine der E- oder F-Reihe und deren C↓15↓-Epimere

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2316924A1 (fr) * 1975-06-23 1977-02-04 Pfizer 11-desoxy-16-aryloxy-o-tetranorprostaglandines
FR2394539A1 (fr) * 1977-06-13 1979-01-12 Pfizer Nouveaux derives substitues en position 15 d'o-pentanorprostaglandine et leur utilisation comme medicament

Also Published As

Publication number Publication date
PT69076A (en) 1979-02-01
IE790060L (en) 1979-07-16
PH15031A (en) 1982-05-13
GR72747B (fr) 1983-12-02
GB2012272B (en) 1982-10-20
IT7919290A0 (it) 1979-01-15
DE2901476B2 (de) 1981-06-04
LU80789A1 (fr) 1980-08-08
CA1152502A (fr) 1983-08-23
GB2012272A (en) 1979-07-25
NZ189377A (en) 1981-05-15
DD141155A5 (de) 1980-04-16
AU507853B2 (en) 1980-02-28
DE2901476C3 (de) 1982-04-22
AU4335979A (en) 1979-07-26
IT1110992B (it) 1986-01-13
FR2414503B1 (fr) 1981-12-24
SE7900353L (sv) 1979-07-17
IL56433A (en) 1982-04-30
IN150279B (fr) 1982-09-04
FI790120A (fi) 1979-07-17
PH15643A (en) 1983-03-11
AR222817A1 (es) 1981-06-30
ATA27579A (de) 1981-12-15
NL7900292A (nl) 1979-07-18
PL117869B1 (en) 1981-08-31
PL212183A1 (fr) 1980-02-11
IL56433A0 (en) 1979-03-12
DE2901476A1 (de) 1979-07-19
IE48175B1 (en) 1984-10-17
PH15653A (en) 1983-03-11
AT367755B (de) 1982-07-26
CH635833A5 (fr) 1983-04-29
JPS54100378A (en) 1979-08-08
YU4579A (en) 1983-01-21
ES482421A1 (es) 1980-04-01
DK523378A (da) 1979-07-17
NO790122L (no) 1979-07-17
SE427657B (sv) 1983-04-25
SU831071A3 (ru) 1981-05-15

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