ES482421A1 - Un procedimiento para la preparacion de nuevos derivados de prostaglandina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de prostaglandina.Info
- Publication number
- ES482421A1 ES482421A1 ES482421A ES482421A ES482421A1 ES 482421 A1 ES482421 A1 ES 482421A1 ES 482421 A ES482421 A ES 482421A ES 482421 A ES482421 A ES 482421A ES 482421 A1 ES482421 A1 ES 482421A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- substituent
- hydrogen
- phenyl
- vinylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 prostaglandin carboxamides Chemical class 0.000 title abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000000694 effects Effects 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 230000035558 fertility Effects 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000001207 fluorophenyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
Abstract
Un procedimiento para la preparación de nuevos derivados de prostaglandina, de fórmula I: **(Fórmula-01)** y opcionalmente para la preparación de una sal farmacológicamente aceptable del mismo donde: A es etileno o cis-vinileno; B es etileno o trans-vinileno; Y es hidrógeno o hidroxi; G es CH2Ar, Ch2OAr o CRZ(CH2)3CH3; Ar es fenilo, fluorfenilo, clorofenilo, metilfenilo, etilfenilo, metoxifenilo, etoxifenilo, bifenilo y trifluor metilfenilo; R es hidrógeno o metilo y Z es hidrógeno o metilo; cuyo procedimiento consiste en: hacer reaccionar un intermediario de fórmula (III): **(Fórmula-02)** donde A, B y G son los definidos anteriormente, con un reactivo de grupos salientes para formar un derivado de un grupo ácido carboxílico con un grupo saliente fácilmente desplazable, seguido de desplazamiento del grupo saliente con 5-aminotetrazol; y después hacer reaccionar opcionalmente con una base metálica, una amina, amoniaco o una base amínica cuaternaria farmacológicamente aceptables para formaruna sal farmacológicamente aceptable de un compuesto de fórmula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86956978A | 1978-01-16 | 1978-01-16 | |
| US89373178A | 1978-04-05 | 1978-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES482421A1 true ES482421A1 (es) | 1980-04-01 |
Family
ID=27128123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482421A Expired ES482421A1 (es) | 1978-01-16 | 1979-07-11 | Un procedimiento para la preparacion de nuevos derivados de prostaglandina. |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS54100378A (es) |
| AR (1) | AR222817A1 (es) |
| AT (1) | AT367755B (es) |
| AU (1) | AU507853B2 (es) |
| CA (1) | CA1152502A (es) |
| CH (1) | CH635833A5 (es) |
| DD (1) | DD141155A5 (es) |
| DE (1) | DE2901476C3 (es) |
| DK (1) | DK523378A (es) |
| ES (1) | ES482421A1 (es) |
| FI (1) | FI790120A (es) |
| FR (1) | FR2414503A1 (es) |
| GB (1) | GB2012272B (es) |
| GR (1) | GR72747B (es) |
| IE (1) | IE48175B1 (es) |
| IL (1) | IL56433A (es) |
| IN (1) | IN150279B (es) |
| IT (1) | IT1110992B (es) |
| LU (1) | LU80789A1 (es) |
| NL (1) | NL7900292A (es) |
| NO (1) | NO790122L (es) |
| NZ (1) | NZ189377A (es) |
| PH (3) | PH15031A (es) |
| PL (1) | PL117869B1 (es) |
| PT (1) | PT69076A (es) |
| SE (1) | SE427657B (es) |
| SU (1) | SU831071A3 (es) |
| YU (1) | YU4579A (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788209A (fr) * | 1971-09-01 | 1973-02-28 | Pfizer | Derives tetrazoyliques des prostaglandines naturelles |
| DD118856A5 (es) * | 1972-11-08 | 1976-03-20 | ||
| IE43462B1 (en) * | 1975-06-23 | 1981-03-11 | Pfizer | Substituted tetranorprostaglandins |
| DE2559093C3 (de) * | 1975-12-30 | 1981-12-24 | Pfizer Inc., 10017 New York, N.Y. | 2-Desarboxy-2-[tetrazol-5-yl]-11-desoxy-ω-pentanorprostaglandine der E- oder F-Reihe und deren C↓15↓-Epimere |
| US4404372A (en) * | 1977-06-13 | 1983-09-13 | Pfizer Inc. | 15-Substituted-ω-pentanorprostaglandin derivatives |
-
1978
- 1978-11-23 IN IN841/DEL/78A patent/IN150279B/en unknown
- 1978-11-23 DK DK523378A patent/DK523378A/da not_active Application Discontinuation
- 1978-12-27 SU SU782715902A patent/SU831071A3/ru active
- 1978-12-27 PL PL1978212183A patent/PL117869B1/pl unknown
- 1978-12-27 DD DD78210198A patent/DD141155A5/de unknown
-
1979
- 1979-01-11 YU YU00045/79A patent/YU4579A/xx unknown
- 1979-01-12 JP JP286979A patent/JPS54100378A/ja active Pending
- 1979-01-12 CA CA000319536A patent/CA1152502A/en not_active Expired
- 1979-01-12 PH PH22056A patent/PH15031A/en unknown
- 1979-01-15 NL NL7900292A patent/NL7900292A/xx not_active Application Discontinuation
- 1979-01-15 FI FI790120A patent/FI790120A/fi unknown
- 1979-01-15 AU AU43359/79A patent/AU507853B2/en not_active Ceased
- 1979-01-15 IL IL56433A patent/IL56433A/xx unknown
- 1979-01-15 FR FR7900857A patent/FR2414503A1/fr active Granted
- 1979-01-15 LU LU80789A patent/LU80789A1/fr unknown
- 1979-01-15 NZ NZ189377A patent/NZ189377A/xx unknown
- 1979-01-15 GB GB791428A patent/GB2012272B/en not_active Expired
- 1979-01-15 NO NO790122A patent/NO790122L/no unknown
- 1979-01-15 GR GR58098A patent/GR72747B/el unknown
- 1979-01-15 CH CH38079A patent/CH635833A5/fr not_active IP Right Cessation
- 1979-01-15 SE SE7900353A patent/SE427657B/sv not_active IP Right Cessation
- 1979-01-15 PT PT69076A patent/PT69076A/pt unknown
- 1979-01-15 IT IT19290/79A patent/IT1110992B/it active
- 1979-01-15 IE IE60/79A patent/IE48175B1/en unknown
- 1979-01-15 AT AT0027579A patent/AT367755B/de not_active IP Right Cessation
- 1979-01-16 AR AR275174A patent/AR222817A1/es active
- 1979-01-16 DE DE2901476A patent/DE2901476C3/de not_active Expired
- 1979-07-11 ES ES482421A patent/ES482421A1/es not_active Expired
- 1979-11-19 PH PH23299A patent/PH15653A/en unknown
- 1979-11-19 PH PH23301A patent/PH15643A/en unknown
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