FR2378777A1 - Nouveaux analogues de prostaglandines - Google Patents
Nouveaux analogues de prostaglandinesInfo
- Publication number
- FR2378777A1 FR2378777A1 FR7802472A FR7802472A FR2378777A1 FR 2378777 A1 FR2378777 A1 FR 2378777A1 FR 7802472 A FR7802472 A FR 7802472A FR 7802472 A FR7802472 A FR 7802472A FR 2378777 A1 FR2378777 A1 FR 2378777A1
- Authority
- FR
- France
- Prior art keywords
- prostaglandins
- ethylene
- alkyl
- new analogues
- trans vinylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 2
- -1 vinylene, ethylene Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- INLLPKCGLOXCIV-UHFFFAOYSA-N bromoethene Chemical group BrC=C INLLPKCGLOXCIV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Abstract
L'invention concerne de nouveaux analogues de prostaglandines, leurs clathrates de cyclodextrine et leurs sels non toxiques. Ces nouveaux composés ont la formule ci-dessous, dans laquelle X = vinylène trans, éthylène ou bromoéthylène, Y = vinylène trans ou éthylène, R**1 = H ou alcoyle, R**2 = H, méthyle ou éthyle, R**3 = liaison simple ou alcoylene, R**4 = H, alcoyle, cycloalcoyle, phényle ou phénoxy. Applications pharmacologiques dans les domaines habituels pour les prostaglandines.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP875177A JPS5395958A (en) | 1977-01-31 | 1977-01-31 | Prostaglandin analogues and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2378777A1 true FR2378777A1 (fr) | 1978-08-25 |
FR2378777B1 FR2378777B1 (fr) | 1980-03-07 |
Family
ID=11701622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7802472A Granted FR2378777A1 (fr) | 1977-01-31 | 1978-01-30 | Nouveaux analogues de prostaglandines |
Country Status (5)
Country | Link |
---|---|
US (1) | US4399147A (fr) |
JP (1) | JPS5395958A (fr) |
DE (1) | DE2803638A1 (fr) |
FR (1) | FR2378777A1 (fr) |
GB (1) | GB1598143A (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2398498A1 (fr) * | 1977-05-06 | 1979-02-23 | Ono Pharmaceutical Co | Compositions stabilisees a usage pharmacologique contenant un analogue de la prostaglandine i2 |
FR2404006A1 (fr) * | 1977-09-23 | 1979-04-20 | Chinoin Gyogyszer Es Vegyeszet | Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments |
EP0007245A1 (fr) * | 1978-07-17 | 1980-01-23 | The Upjohn Company | Compositions contenant un prostacyclin ou prostacyclin analogue contenant un enol ether groupe |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU182583B (en) * | 1977-03-01 | 1984-02-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing prostacyclin and analogues thereof |
BE871209R (fr) * | 1977-12-05 | 1979-04-12 | Upjohn Co | Analogues de 5,6-dihydro-prostacycline et leur preparation |
IL58384A0 (en) | 1978-10-14 | 1980-01-31 | Beecham Group Ltd | 12-aza analogues of prostcyclin their preparation and pharmaceutical composition containing them |
DE3035713A1 (de) * | 1980-09-22 | 1982-04-29 | F. Hoffmann-La Roche & Co. AG, 4002 Basel | Prostacycline |
JPS58164512A (ja) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2351112A1 (fr) * | 1975-10-21 | 1977-12-09 | Wellcome Found | Derive de prostaglandine et medicament contenant ce derive |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5823393B2 (ja) * | 1974-03-14 | 1983-05-14 | オノヤクヒンコウギヨウ カブシキガイシヤ | プロスタグランジンルイジカゴウブツ ノ セイゾウホウホウ |
GB1484591A (en) * | 1974-04-11 | 1977-09-01 | Ono Pharmaceutical Co | Prostaglandin compositions |
-
1977
- 1977-01-31 JP JP875177A patent/JPS5395958A/ja active Pending
-
1978
- 1978-01-26 US US05/872,635 patent/US4399147A/en not_active Expired - Lifetime
- 1978-01-27 DE DE19782803638 patent/DE2803638A1/de not_active Withdrawn
- 1978-01-30 GB GB3652/78A patent/GB1598143A/en not_active Expired
- 1978-01-30 FR FR7802472A patent/FR2378777A1/fr active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2351112A1 (fr) * | 1975-10-21 | 1977-12-09 | Wellcome Found | Derive de prostaglandine et medicament contenant ce derive |
Non-Patent Citations (3)
Title |
---|
EXBK/77 * |
NV6011/71 * |
NV6013/77 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2398498A1 (fr) * | 1977-05-06 | 1979-02-23 | Ono Pharmaceutical Co | Compositions stabilisees a usage pharmacologique contenant un analogue de la prostaglandine i2 |
FR2404006A1 (fr) * | 1977-09-23 | 1979-04-20 | Chinoin Gyogyszer Es Vegyeszet | Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments |
EP0007245A1 (fr) * | 1978-07-17 | 1980-01-23 | The Upjohn Company | Compositions contenant un prostacyclin ou prostacyclin analogue contenant un enol ether groupe |
Also Published As
Publication number | Publication date |
---|---|
DE2803638A1 (de) | 1978-08-03 |
JPS5395958A (en) | 1978-08-22 |
FR2378777B1 (fr) | 1980-03-07 |
GB1598143A (en) | 1981-09-16 |
US4399147A (en) | 1983-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |