FR2381043A1 - Nouveaux analogues de prostaglandines, leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouveaux analogues de prostaglandines, leur preparation et les compositions pharmaceutiques qui les contiennentInfo
- Publication number
- FR2381043A1 FR2381043A1 FR7804693A FR7804693A FR2381043A1 FR 2381043 A1 FR2381043 A1 FR 2381043A1 FR 7804693 A FR7804693 A FR 7804693A FR 7804693 A FR7804693 A FR 7804693A FR 2381043 A1 FR2381043 A1 FR 2381043A1
- Authority
- FR
- France
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- prostaglandin analogues
- new prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- -1 R ** 2 = H Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne de nouveaux analogues de prostaglandines, leurs chlathrates de cyclodextrine et leurs sels. Ces nouveaux analogues ont la formule ci-dessous, dans laquelle Y = vinylène trans ou éthylène, R**1 = H ou alcoyle, R**2 = H, méthyle ou éthyle, R**3 = liaison simple ou alcoylene, R**4, R**5, R**6 = atomes H et/ou alcoyles, n = 3 à 6, et la double liaison C5 -C6 est Z ou E. Applications pharmacologiques dans les domaines habituels pour les prostaglandines.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1714177A JPS53103464A (en) | 1977-02-21 | 1977-02-21 | Prostaglandin x analogues and process for their preparation |
JP3049477A JPS53116365A (en) | 1977-03-22 | 1977-03-22 | Prostaglandin x analogous compounds and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2381043A1 true FR2381043A1 (fr) | 1978-09-15 |
FR2381043B1 FR2381043B1 (fr) | 1980-04-18 |
Family
ID=26353629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7804693A Granted FR2381043A1 (fr) | 1977-02-21 | 1978-02-20 | Nouveaux analogues de prostaglandines, leur preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (4)
Country | Link |
---|---|
US (1) | US4178367A (fr) |
DE (1) | DE2807178A1 (fr) |
FR (1) | FR2381043A1 (fr) |
GB (1) | GB1598953A (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2398498A1 (fr) * | 1977-05-06 | 1979-02-23 | Ono Pharmaceutical Co | Compositions stabilisees a usage pharmacologique contenant un analogue de la prostaglandine i2 |
FR2401141A1 (fr) * | 1977-03-07 | 1979-03-23 | Upjohn Co | Nouveaux derives halogenes de prostaglandines et medicaments les contenant |
FR2404006A1 (fr) * | 1977-09-23 | 1979-04-20 | Chinoin Gyogyszer Es Vegyeszet | Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments |
EP0163905A1 (fr) * | 1984-01-13 | 1985-12-11 | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. | Dérivés de 7-oxo-prostacycline racémiques et optiquement actifs, procédé pour leur préparation et compositions pharmaceutiques contenant ces composés |
EP0196380A2 (fr) * | 1984-07-23 | 1986-10-08 | Ono Pharmaceutical Co., Ltd. | Analogues de prostaglandines, leurs procédés de préparation et leurs compositions pharmaceutiques |
US5221689A (en) * | 1984-07-23 | 1993-06-22 | Ono Pharmaceutical Co., Ltd. | Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54125653A (en) * | 1978-03-18 | 1979-09-29 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent |
IL58384A0 (en) | 1978-10-14 | 1980-01-31 | Beecham Group Ltd | 12-aza analogues of prostcyclin their preparation and pharmaceutical composition containing them |
DE2947526A1 (de) * | 1978-11-29 | 1980-06-12 | Ono Pharmaceutical Co | Prostacyclin-analoge |
DE2902809A1 (de) * | 1979-01-25 | 1980-08-07 | Hoechst Ag | Neue analoga von prostacyclin |
CH651033A5 (de) * | 1981-03-11 | 1985-08-30 | Hoffmann La Roche | Fluorprostacycline. |
JPS58164512A (ja) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤 |
DE3315356A1 (de) * | 1982-04-30 | 1983-11-17 | Ono Pharmaceutical Co. Ltd., Osaka | Verwendung von prostaglandinanalogen |
JPS58203911A (ja) * | 1982-05-25 | 1983-11-28 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤 |
US4616034A (en) * | 1985-02-28 | 1986-10-07 | G. D. Searle & Co. | 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI71138C (fi) * | 1976-12-31 | 1986-11-24 | Erba Farmitalia | Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner |
JPS5446773A (en) * | 1977-09-22 | 1979-04-12 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog and its preparation |
DE2753244A1 (de) * | 1977-11-25 | 1979-06-07 | Schering Ag | Neue prostacyclinderivate und verfahren zu ihrer herstellung |
DE2801846A1 (de) * | 1978-01-13 | 1979-07-19 | Schering Ag | Neue prostacyclinderivate und verfahren zu ihrer herstellung |
-
1978
- 1978-02-16 US US05/878,571 patent/US4178367A/en not_active Expired - Lifetime
- 1978-02-20 GB GB6675/78A patent/GB1598953A/en not_active Expired
- 1978-02-20 DE DE19782807178 patent/DE2807178A1/de not_active Ceased
- 1978-02-20 FR FR7804693A patent/FR2381043A1/fr active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2401141A1 (fr) * | 1977-03-07 | 1979-03-23 | Upjohn Co | Nouveaux derives halogenes de prostaglandines et medicaments les contenant |
FR2398498A1 (fr) * | 1977-05-06 | 1979-02-23 | Ono Pharmaceutical Co | Compositions stabilisees a usage pharmacologique contenant un analogue de la prostaglandine i2 |
FR2404006A1 (fr) * | 1977-09-23 | 1979-04-20 | Chinoin Gyogyszer Es Vegyeszet | Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments |
EP0163905A1 (fr) * | 1984-01-13 | 1985-12-11 | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. | Dérivés de 7-oxo-prostacycline racémiques et optiquement actifs, procédé pour leur préparation et compositions pharmaceutiques contenant ces composés |
EP0196380A2 (fr) * | 1984-07-23 | 1986-10-08 | Ono Pharmaceutical Co., Ltd. | Analogues de prostaglandines, leurs procédés de préparation et leurs compositions pharmaceutiques |
EP0196380A3 (en) * | 1984-07-23 | 1987-07-01 | Ono Pharmaceutical Co., Ltd. | Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them |
US4935446A (en) * | 1984-07-23 | 1990-06-19 | Ono Pharmaceutical Co., Ltd. | Prostaglandin analogues, process for their preparation and pharmaceutical compositions containing them |
US5221689A (en) * | 1984-07-23 | 1993-06-22 | Ono Pharmaceutical Co., Ltd. | Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
US4178367A (en) | 1979-12-11 |
DE2807178A1 (de) | 1978-08-24 |
GB1598953A (en) | 1981-09-30 |
FR2381043B1 (fr) | 1980-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2381043A1 (fr) | Nouveaux analogues de prostaglandines, leur preparation et les compositions pharmaceutiques qui les contiennent | |
FR2422635A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
FR2416234A1 (fr) | Derives de metronidazole et compositions pharmaceutiques en contenant | |
FR2392971A1 (fr) | Derives de l'acide prostanoique, leur preparation et medicament contenant ces substances | |
FR2453851A1 (fr) | Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant | |
FR2355028A1 (fr) | Procede pour la preparation de glycosides derives d'anthracyclines optiquement actives | |
FR2418794A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
FR2404005A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
FR2394546A1 (fr) | Nouveaux derives de 1,2,3,4,6,7-hexahydro-11bah-benzo(a)-quinolizine, leur preparation et leur application en tant que medicaments | |
FR2378777A1 (fr) | Nouveaux analogues de prostaglandines | |
BE904656A (fr) | Ethers cyclopentyliques, leur preparation et formulations pharmaceutiques les contenant. | |
FR2442844A1 (fr) | Analogues de la prostaglandine i1 et compositions pharmaceutiques les contenant | |
FR2375239A1 (fr) | Derives d'acide 7-amino-8-oxo-3-oxa-1-azabicyclo-(4.2.0)octane-2-carboxylique | |
BE901889A (fr) | Nouveaux polyethers glycosyles leur procede de preparation et leur utilisation. | |
FR2447375A1 (fr) | Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant | |
FR2419935A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
FR2401139A2 (fr) | Nouveaux derives d5 de prostaglandines, leur procede de preparation et medicaments les contenant | |
FR2362832A1 (fr) | Derives de 2, o-phenoxy-tetranorprostaglandines e | |
FR2421616A1 (fr) | Nouveaux medicaments constitues de derives de l'acide o-aminobenzoique | |
FR2397402A1 (fr) | Nouveaux analogues de prostaglandines et les compositions pharmaceutiques les contenant | |
FR2404637A1 (fr) | Analogues de prostaglandines et compositions pharmaceutiques les contenant | |
FR2394511A1 (fr) | Nouveaux analogues de prostaglandines et compositions pharmaceutiques qui les contiennent | |
FR2449680A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
US4336372A (en) | 2-Decarboxy-2-tetrazolyl-PG2 compounds | |
FR2401153A1 (fr) | Nouveaux derives de la benzo-cyclohepta-thiophenone et leur preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |