FR22C1056I1 - Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs aav - Google Patents
Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs aavInfo
- Publication number
- FR22C1056I1 FR22C1056I1 FR22C1056C FR22C1056C FR22C1056I1 FR 22C1056 I1 FR22C1056 I1 FR 22C1056I1 FR 22C1056 C FR22C1056 C FR 22C1056C FR 22C1056 C FR22C1056 C FR 22C1056C FR 22C1056 I1 FR22C1056 I1 FR 22C1056I1
- Authority
- FR
- France
- Prior art keywords
- peripheral
- gene delivery
- aav vector
- motor neurons
- vector injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07301435A EP2058401A1 (fr) | 2007-10-05 | 2007-10-05 | Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs AAV |
EP19158152.9A EP3505635B1 (fr) | 2007-10-05 | 2008-10-03 | Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs aav |
Publications (1)
Publication Number | Publication Date |
---|---|
FR22C1056I1 true FR22C1056I1 (fr) | 2023-01-06 |
Family
ID=39186802
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR20C1057C Active FR20C1057I2 (fr) | 2007-10-05 | 2020-11-17 | Délivrance à large diffusion de gènes à des neurones moteurs par injection périphérique de vecteurs aav |
FR22C1056C Active FR22C1056I1 (fr) | 2007-10-05 | 2022-11-17 | Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs aav |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR20C1057C Active FR20C1057I2 (fr) | 2007-10-05 | 2020-11-17 | Délivrance à large diffusion de gènes à des neurones moteurs par injection périphérique de vecteurs aav |
Country Status (18)
Country | Link |
---|---|
US (3) | US9926574B2 (fr) |
EP (5) | EP2058401A1 (fr) |
JP (2) | JP5620819B2 (fr) |
CN (2) | CN101883859A (fr) |
CA (2) | CA2999607A1 (fr) |
CY (1) | CY1125608T1 (fr) |
DK (2) | DK2212424T3 (fr) |
ES (3) | ES2727034T3 (fr) |
FI (1) | FI2212424T4 (fr) |
FR (2) | FR20C1057I2 (fr) |
HR (2) | HRP20220992T3 (fr) |
HU (2) | HUE059864T2 (fr) |
LT (2) | LT3505635T (fr) |
NO (1) | NO2022048I1 (fr) |
PL (2) | PL3505635T3 (fr) |
PT (3) | PT2212424E (fr) |
SI (2) | SI3505635T1 (fr) |
WO (1) | WO2009043936A1 (fr) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120322861A1 (en) | 2007-02-23 | 2012-12-20 | Barry John Byrne | Compositions and Methods for Treating Diseases |
EP2019143A1 (fr) * | 2007-07-23 | 2009-01-28 | Genethon | Thérapie génique du CNS utilisant l'administration périphérique de vecteurs AAV |
EP2058401A1 (fr) * | 2007-10-05 | 2009-05-13 | Genethon | Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs AAV |
DK3043181T3 (da) | 2008-01-15 | 2020-05-04 | Univ Leland Stanford Junior | Markører af akutte myeloid-leukæmi-stamceller |
US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
US9415121B2 (en) | 2008-12-19 | 2016-08-16 | Nationwide Children's Hospital | Delivery of MECP2 polynucleotide using recombinant AAV9 |
JP5879256B2 (ja) | 2009-05-02 | 2016-03-08 | ジェンザイム・コーポレーション | 神経変性障害のための遺伝子治療 |
US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
CA2833912C (fr) | 2010-04-23 | 2021-09-21 | University Of Massachusetts | Traitement a base d'aav pour des troubles lies au cholesterol |
CA3066596A1 (fr) * | 2010-04-23 | 2011-10-27 | University Of Massachusetts | Vecteurs aav ciblant le systeme nerveux central et leurs procedes d'utilisation |
CA2833905C (fr) | 2010-04-23 | 2019-09-10 | University Of Massachusetts | Constructions d'expression a cistrons multiples |
CN107828820B (zh) * | 2010-10-27 | 2022-06-07 | 学校法人自治医科大学 | 用于向神经系统细胞导入基因的腺相关病毒粒子 |
WO2012145624A2 (fr) | 2011-04-21 | 2012-10-26 | University Of Massachusetts | Compositions à base de raav et procédés pour traiter des déficiences en anti-trypsine alpha-1 |
US20130039888A1 (en) * | 2011-06-08 | 2013-02-14 | Nationwide Children's Hospital Inc. | Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders |
RU2015101276A (ru) * | 2012-06-19 | 2016-08-10 | Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. | Способы лечения болезней и композиции для их осуществления |
US20150182637A1 (en) * | 2012-06-21 | 2015-07-02 | Association Institut De Myologie | Widespread gene delivery of gene therapy vectors |
PT2879719T (pt) | 2012-08-01 | 2018-10-08 | Ohio State Innovation Foundation | Administração intratecal do vírus adeno-associado 9 recombinante |
JP2015529685A (ja) | 2012-09-17 | 2015-10-08 | ザ・リサーチ・インスティテュート・アット・ネイションワイド・チルドレンズ・ホスピタルThe Research Institute Atnationwide Children’S Hospital | 筋萎縮性側索硬化症の処置のための組成物および方法 |
CA2912678C (fr) * | 2013-05-15 | 2023-10-10 | Regents Of The University Of Minnesota | Transfert genique au systeme nerveux central a mediation par un virus adeno-associe |
PT3702466T (pt) | 2013-08-27 | 2023-01-24 | Res Inst Nationwide Childrens Hospital | Produtos e métodos para tratamento de esclerose lateral amiotrófica |
AU2014346987A1 (en) | 2013-11-05 | 2016-06-23 | The Research Institute At Nationwide Children's Hospital | Compositions and methods for inhibiting NF-kB and SOD-1 to treat amyotrophic lateral sclerosis |
CA2939950C (fr) * | 2014-03-09 | 2023-08-22 | The Trustees Of The University Of Pennsylvania | Compositions utiles dans le traitement du deficit en ornithine transcarbamylase (otc) |
EP2933335A1 (fr) * | 2014-04-18 | 2015-10-21 | Genethon | Procédé de traitement de neuropathies périphériques et sclérose latérale amyotrophique |
US10689653B2 (en) | 2014-06-03 | 2020-06-23 | University Of Massachusetts | Compositions and methods for modulating dysferlin expression |
EP3174981B1 (fr) | 2014-07-31 | 2020-03-25 | Association Institut de Myologie | Traitement de la sclérose latérale amyotrophique |
US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
EP3200830B1 (fr) | 2014-10-03 | 2020-09-09 | University of Massachusetts | Vecteurs aav identifiés au moyen de banques à efficacité élevée |
RU2738421C2 (ru) | 2014-10-21 | 2020-12-14 | Юниверсити Оф Массачусетс | Варианты рекомбинантных aav и их применения |
MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
RU2727015C2 (ru) | 2014-11-21 | 2020-07-17 | Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл | Векторы aav, нацеленные на центральную нервную систему |
EP3233131A1 (fr) | 2014-12-16 | 2017-10-25 | Board of Regents of the University of Nebraska | Thérapie génique pour la maladie de steinert juvénile |
US10584321B2 (en) | 2015-02-13 | 2020-03-10 | University Of Massachusetts | Compositions and methods for transient delivery of nucleases |
EP3280451B8 (fr) * | 2015-04-08 | 2019-09-25 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Thérapie génique virale à utiliser en tant que traitement pour une maladie ou un trouble associé au stockage du cholestérol |
CA3021949C (fr) | 2015-04-24 | 2023-10-17 | University Of Massachusetts | Constructions d'aav modifiees et utilisations de celles-ci |
JP7097070B2 (ja) * | 2015-10-01 | 2022-07-07 | ゴレイニ インコーポレイテッド | クロライドチャネルの標的発現及びその使用方法 |
DK3365438T3 (da) * | 2015-10-21 | 2021-07-12 | Us Health | Codon-optimeret reduceret-størrelse atp7a cdna og anvendelser ved behandling af kobbertransportlidelser |
WO2017070525A1 (fr) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Procédés et compositions pour le traitement du déséquilibre métabolique dans une maladie neurodégénérative |
WO2017070516A1 (fr) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Vecteurs du sérotype de virus adéno-associés ciblant la prostate |
EP3368054A4 (fr) | 2015-10-28 | 2019-07-03 | Voyager Therapeutics, Inc. | Expression régulable au moyen d'un virus adéno-associé (vaa) |
US11826433B2 (en) | 2016-02-02 | 2023-11-28 | University Of Massachusetts | Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system |
EP4094780A3 (fr) | 2016-02-12 | 2023-02-08 | University of Massachusetts | Thérapeutiques micro-arn anti-angiogéniques pour l'inhibition de la néovascularisation de la cornée |
EP3440210A4 (fr) | 2016-04-05 | 2019-11-27 | University of Massachusetts | Compositions et procédés pour l'inhibition sélective de l'expression d'une protéine de type grainhead |
KR20230125339A (ko) | 2016-04-15 | 2023-08-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ii형 점액다당류증의 치료를 위한 유전자 요법 |
WO2017181105A1 (fr) | 2016-04-15 | 2017-10-19 | University Of Massachusetts | Méthodes et compositions pour le traitement de déséquilibres métaboliques |
US11504435B2 (en) | 2016-06-13 | 2022-11-22 | The University Of North Carolina At Chapel Hill | Optimized CLN1 genes and expression cassettes and their use |
WO2017218852A1 (fr) | 2016-06-15 | 2017-12-21 | University Of Massachusetts | Virus adéno-associés de recombinaison pour l'administration de molécules d'édition de gènes dans des cellules embryonnaires |
EP3831281A1 (fr) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Procédés de ciblage et d'administration biomédicaux, et dispositifs et systèmes pour leur mise en uvre |
US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
KR20190075964A (ko) | 2016-10-13 | 2019-07-01 | 유니버시티 오브 매사추세츠 | Aav 캡시드 설계 |
CN108524952A (zh) * | 2017-03-06 | 2018-09-14 | 复旦大学 | 腺相关病毒aav9及其在制备治疗戈谢氏病的制剂中的用途 |
CN110913866A (zh) | 2017-05-05 | 2020-03-24 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
WO2019018342A1 (fr) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | Systeme de guide de trajectoire d'appareillage en reseau |
EP3662060A2 (fr) | 2017-08-03 | 2020-06-10 | Voyager Therapeutics, Inc. | Compositions et procedes de délivrance d'aav |
BR112020005249A2 (pt) | 2017-09-22 | 2020-09-24 | The Trustees Of The University Of Pennsylvania | terapia de gene para tratar mucopolissacaridose tipo ii |
US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
JP7502991B2 (ja) | 2017-10-16 | 2024-06-19 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症(als)の治療 |
CA3082136A1 (fr) * | 2017-11-08 | 2019-05-16 | Avexis, Inc. | Moyens et procede de preparation de vecteurs viraux et leurs utilisations |
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JP7244547B2 (ja) | 2018-02-19 | 2023-03-22 | ホモロジー・メディシンズ・インコーポレイテッド | F8遺伝子機能を回復させるためのアデノ随伴ウイルス組成物及びその使用の方法 |
JP7406677B2 (ja) | 2018-04-03 | 2023-12-28 | ギンコ バイオワークス インコーポレイテッド | 抗体を回避するウイルスベクター |
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CA3099306A1 (fr) | 2018-05-15 | 2019-11-21 | Voyager Therapeutics, Inc. | Compositions et methodes pour le traitement de la maladie de parkinson |
WO2019222444A2 (fr) | 2018-05-16 | 2019-11-21 | Voyager Therapeutics, Inc. | Évolution dirigée |
WO2020010035A1 (fr) | 2018-07-02 | 2020-01-09 | Voyager Therapeutics, Inc. | Système de canule |
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US20210355454A1 (en) | 2018-07-24 | 2021-11-18 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
TW202035689A (zh) | 2018-10-04 | 2020-10-01 | 美商航海家醫療公司 | 測量病毒載體粒子的效價及強度之方法 |
WO2020077165A1 (fr) | 2018-10-12 | 2020-04-16 | Voyager Therapeutics, Inc. | Compositions et procédés pour l'administration d'aav |
AU2020208467A1 (en) | 2019-01-18 | 2021-08-05 | Voyager Therapeutics, Inc. | Methods and systems for producing AAV particles |
MX2021009161A (es) * | 2019-02-05 | 2021-09-10 | Univ Princeton | Acidos nucleicos recombinantes que contienen secuencias promotoras de alfaherpesvirus. |
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