FR2001977A1 - Process for the prepn. of cell-free penicillin-acylase by fermenting a strain of E. coli which produces this enzyme. The intracellular enzyme is separated form - Google Patents

Process for the prepn. of cell-free penicillin-acylase by fermenting a strain of E. coli which produces this enzyme. The intracellular enzyme is separated form

Info

Publication number
FR2001977A1
FR2001977A1 FR6903732A FR6903732A FR2001977A1 FR 2001977 A1 FR2001977 A1 FR 2001977A1 FR 6903732 A FR6903732 A FR 6903732A FR 6903732 A FR6903732 A FR 6903732A FR 2001977 A1 FR2001977 A1 FR 2001977A1
Authority
FR
France
Prior art keywords
enzyme
cell
acylase
prepn
fermenting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6903732A
Other languages
English (en)
Other versions
FR2001977B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB57373/68A external-priority patent/GB1261711A/en
Application filed by Astra AB filed Critical Astra AB
Publication of FR2001977A1 publication Critical patent/FR2001977A1/fr
Application granted granted Critical
Publication of FR2001977B1 publication Critical patent/FR2001977B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Handcart (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
FR6903732A 1968-02-15 1969-02-14 Process for the prepn. of cell-free penicillin-acylase by fermenting a strain of E. coli which produces this enzyme. The intracellular enzyme is separated form Granted FR2001977A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB754468 1968-02-15
GB57373/68A GB1261711A (en) 1968-02-15 1968-12-03 Process for producing a penicillin acylose composition

Publications (2)

Publication Number Publication Date
FR2001977A1 true FR2001977A1 (en) 1969-10-03
FR2001977B1 FR2001977B1 (fr) 1974-08-30

Family

ID=26241501

Family Applications (2)

Application Number Title Priority Date Filing Date
FR6903732A Granted FR2001977A1 (en) 1968-02-15 1969-02-14 Process for the prepn. of cell-free penicillin-acylase by fermenting a strain of E. coli which produces this enzyme. The intracellular enzyme is separated form
FR7045429A Expired FR2081316B1 (fr) 1968-02-15 1970-12-16

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7045429A Expired FR2081316B1 (fr) 1968-02-15 1970-12-16

Country Status (17)

Country Link
JP (2) JPS4833386B1 (fr)
AT (2) AT297218B (fr)
BE (1) BE727506A (fr)
CA (1) CA941769A (fr)
CH (2) CH523320A (fr)
CS (1) CS155970B2 (fr)
DE (4) DE1966428C3 (fr)
DK (1) DK128421B (fr)
ES (4) ES363592A1 (fr)
FI (1) FI47109C (fr)
FR (2) FR2001977A1 (fr)
IE (1) IE32962B1 (fr)
IT (1) IT1061759B (fr)
NL (1) NL158547B (fr)
NO (3) NO131388C (fr)
SE (3) SE382990B (fr)
SU (1) SU404195A3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2161021A1 (fr) * 1971-11-23 1973-07-06 Bayer Ag

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1357317A (en) * 1970-08-27 1974-06-19 Beecham Group Ltd Enzymes
IL39158A (en) * 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
JPS5420193A (en) * 1977-07-12 1979-02-15 Tanabe Seiyaku Co Ltd Immobilized aminoacylase and its preparation
GB9718740D0 (en) 1997-09-05 1997-11-12 Advanced Phytonics Ltd Improvements in or relating to the preparation of a compound
DE10123048A1 (de) * 2001-05-11 2002-11-21 Bermatingen Maschf Messer für Kreiselmulchgeräte

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB877898A (en) * 1956-12-06 1961-09-20 Apv Co Ltd A new or improved method of liberating enzymes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1118566A (en) * 1964-11-25 1968-07-03 Beecham Group Ltd Production of 6-aminopenicillanic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB877898A (en) * 1956-12-06 1961-09-20 Apv Co Ltd A new or improved method of liberating enzymes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2161021A1 (fr) * 1971-11-23 1973-07-06 Bayer Ag

Also Published As

Publication number Publication date
SU404195A3 (fr) 1973-10-26
NO131388C (fr) 1975-05-21
ES384025A1 (es) 1973-04-16
CA941769A (en) 1974-02-12
FR2081316A1 (fr) 1971-12-03
NO131387C (fr) 1975-05-21
FI47109B (fr) 1973-05-31
JPS5622278B1 (fr) 1981-05-23
DK128421B (da) 1974-04-29
SE382990B (sv) 1976-02-23
IT1061759B (it) 1983-04-30
DE1907365A1 (de) 1969-09-11
JPS4833386B1 (fr) 1973-10-13
NO131387B (fr) 1975-02-10
IE32962L (en) 1969-08-15
NL158547B (nl) 1978-11-15
ES384026A1 (es) 1973-04-16
NL6902045A (fr) 1969-08-19
DE1966427A1 (de) 1972-08-24
ES384027A1 (es) 1973-06-01
SE400291B (sv) 1978-03-20
DE1966428C3 (de) 1978-03-02
FR2081316B1 (fr) 1974-08-30
FI47109C (fi) 1973-09-10
SE352643B (fr) 1973-01-08
CS155970B2 (fr) 1974-06-24
FR2001977B1 (fr) 1974-08-30
DE1966428B2 (de) 1977-07-21
DE1966427B2 (de) 1979-07-12
NO131388B (fr) 1975-02-10
CH523320A (de) 1972-05-31
IE32962B1 (en) 1974-02-06
CH538540A (de) 1973-08-15
BE727506A (fr) 1969-07-01
AT297218B (de) 1972-03-10
DE1933301A1 (de) 1970-06-25
AT300198B (de) 1972-07-10
NO131386B (fr) 1975-02-10
DE1966428A1 (de) 1972-09-14
DE1966427C3 (de) 1980-03-13
NO131386C (fr) 1975-05-21
ES363592A1 (es) 1970-12-16

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Legal Events

Date Code Title Description
ST Notification of lapse