DK128421B - Fremgangsmåde til fremstilling af en cellefri penicillinacylase. - Google Patents

Fremgangsmåde til fremstilling af en cellefri penicillinacylase.

Info

Publication number
DK128421B
DK128421B DK80469AA DK80469A DK128421B DK 128421 B DK128421 B DK 128421B DK 80469A A DK80469A A DK 80469AA DK 80469 A DK80469 A DK 80469A DK 128421 B DK128421 B DK 128421B
Authority
DK
Denmark
Prior art keywords
cell
preparation
penicillin acylase
free penicillin
free
Prior art date
Application number
DK80469AA
Other languages
English (en)
Inventor
Per Staffan Delin
Bertil Aake Ekstroem
Berndt Olof Harald Sjoeberg
Karl Hugo Thelin
Lars Soelve Nathorst-Westfelt
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB57373/68A external-priority patent/GB1261711A/en
Application filed by Astra Ab filed Critical Astra Ab
Priority to DK472571A priority Critical patent/DK130531B/da
Priority to DK472471A priority patent/DK130743B/da
Publication of DK128421B publication Critical patent/DK128421B/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84Penicillin amidase (3.5.1.11)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Handcart (AREA)
  • Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK80469AA 1968-02-15 1969-02-14 Fremgangsmåde til fremstilling af en cellefri penicillinacylase. DK128421B (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK472571A DK130531B (da) 1968-02-15 1971-09-29 Fremgangsmåde til fremstilling af som udgangsmateriale for fremstilling af hypoallergene penicilliner anvendelig 6-aminopenicillansyre.
DK472471A DK130743B (da) 1968-02-15 1971-09-29 Fremgangsmåde til ud fra Escherichia coli at fremstille en til et polymert materiale kemisk bundet, cellefri penicillinacylase beregnet til anvendelse ved fremstilling af hypoallergen 6-aminopenicillansyre og ved syntese af hypoallergene penicilliner.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB754468 1968-02-15
GB57373/68A GB1261711A (en) 1968-02-15 1968-12-03 Process for producing a penicillin acylose composition

Publications (1)

Publication Number Publication Date
DK128421B true DK128421B (da) 1974-04-29

Family

ID=26241501

Family Applications (1)

Application Number Title Priority Date Filing Date
DK80469AA DK128421B (da) 1968-02-15 1969-02-14 Fremgangsmåde til fremstilling af en cellefri penicillinacylase.

Country Status (17)

Country Link
JP (2) JPS4833386B1 (da)
AT (2) AT297218B (da)
BE (1) BE727506A (da)
CA (1) CA941769A (da)
CH (2) CH523320A (da)
CS (1) CS155970B2 (da)
DE (4) DE1966427C3 (da)
DK (1) DK128421B (da)
ES (4) ES363592A1 (da)
FI (1) FI47109C (da)
FR (2) FR2001977A1 (da)
IE (1) IE32962B1 (da)
IT (1) IT1061759B (da)
NL (1) NL158547B (da)
NO (3) NO131388C (da)
SE (3) SE382990B (da)
SU (1) SU404195A3 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1357317A (en) * 1970-08-27 1974-06-19 Beecham Group Ltd Enzymes
IL39158A (en) * 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
BE791748A (fr) * 1971-11-23 1973-05-22 Bayer Ag Procede de production d'acide 6-aminopenicillanique par ruptureenzymatique de penicillines
JPS5420193A (en) * 1977-07-12 1979-02-15 Tanabe Seiyaku Co Ltd Immobilized aminoacylase and its preparation
GB9718740D0 (en) * 1997-09-05 1997-11-12 Advanced Phytonics Ltd Improvements in or relating to the preparation of a compound
DE10123048A1 (de) * 2001-05-11 2002-11-21 Bermatingen Maschf Messer für Kreiselmulchgeräte

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB877898A (en) * 1956-12-06 1961-09-20 Apv Co Ltd A new or improved method of liberating enzymes
GB1118566A (en) * 1964-11-25 1968-07-03 Beecham Group Ltd Production of 6-aminopenicillanic acid

Also Published As

Publication number Publication date
CH523320A (de) 1972-05-31
SU404195A3 (da) 1973-10-26
NO131388B (da) 1975-02-10
FI47109B (da) 1973-05-31
DE1966427B2 (de) 1979-07-12
FR2001977A1 (en) 1969-10-03
DE1966428B2 (de) 1977-07-21
NL6902045A (da) 1969-08-19
ES384027A1 (es) 1973-06-01
CS155970B2 (da) 1974-06-24
IT1061759B (it) 1983-04-30
ES384025A1 (es) 1973-04-16
AT300198B (de) 1972-07-10
ES384026A1 (es) 1973-04-16
IE32962B1 (en) 1974-02-06
DE1907365A1 (de) 1969-09-11
NO131386B (da) 1975-02-10
FI47109C (fi) 1973-09-10
JPS4833386B1 (da) 1973-10-13
DE1966427A1 (de) 1972-08-24
NO131387B (da) 1975-02-10
SE382990B (sv) 1976-02-23
CH538540A (de) 1973-08-15
DE1966428A1 (de) 1972-09-14
NL158547B (nl) 1978-11-15
FR2081316B1 (da) 1974-08-30
DE1966428C3 (de) 1978-03-02
DE1966427C3 (de) 1980-03-13
FR2081316A1 (da) 1971-12-03
NO131387C (da) 1975-05-21
BE727506A (da) 1969-07-01
JPS5622278B1 (da) 1981-05-23
AT297218B (de) 1972-03-10
SE400291B (sv) 1978-03-20
NO131388C (da) 1975-05-21
FR2001977B1 (da) 1974-08-30
DE1933301A1 (de) 1970-06-25
IE32962L (en) 1969-08-15
NO131386C (da) 1975-05-21
ES363592A1 (es) 1970-12-16
CA941769A (en) 1974-02-12
SE352643B (da) 1973-01-08

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