DK128421B - Process for the preparation of a cell-free penicillin acylase. - Google Patents

Process for the preparation of a cell-free penicillin acylase.

Info

Publication number
DK128421B
DK128421B DK80469AA DK80469A DK128421B DK 128421 B DK128421 B DK 128421B DK 80469A A DK80469A A DK 80469AA DK 80469 A DK80469 A DK 80469A DK 128421 B DK128421 B DK 128421B
Authority
DK
Denmark
Prior art keywords
cell
preparation
penicillin acylase
free penicillin
free
Prior art date
Application number
DK80469AA
Other languages
Danish (da)
Inventor
Per Staffan Delin
Bertil Aake Ekstroem
Berndt Olof Harald Sjoeberg
Karl Hugo Thelin
Lars Soelve Nathorst-Westfelt
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB57373/68A external-priority patent/GB1261711A/en
Application filed by Astra Ab filed Critical Astra Ab
Priority to DK472471A priority Critical patent/DK130743B/en
Priority to DK472571A priority patent/DK130531B/en
Publication of DK128421B publication Critical patent/DK128421B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Handcart (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
DK80469AA 1968-02-15 1969-02-14 Process for the preparation of a cell-free penicillin acylase. DK128421B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK472471A DK130743B (en) 1968-02-15 1971-09-29 Process for the preparation from Escherichia coli of a chemically bound penicillin acylase chemically bound to a polymeric material intended for use in the preparation of hypoallergenic 6-aminopenicillanic acid and in the synthesis of hypoallergenic penicillins.
DK472571A DK130531B (en) 1968-02-15 1971-09-29 Process for the preparation of 6-aminopenicillanic acid which can be used as starting material for the preparation of hypoallergenic penicillins.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB754468 1968-02-15
GB57373/68A GB1261711A (en) 1968-02-15 1968-12-03 Process for producing a penicillin acylose composition

Publications (1)

Publication Number Publication Date
DK128421B true DK128421B (en) 1974-04-29

Family

ID=26241501

Family Applications (1)

Application Number Title Priority Date Filing Date
DK80469AA DK128421B (en) 1968-02-15 1969-02-14 Process for the preparation of a cell-free penicillin acylase.

Country Status (17)

Country Link
JP (2) JPS4833386B1 (en)
AT (2) AT297218B (en)
BE (1) BE727506A (en)
CA (1) CA941769A (en)
CH (2) CH523320A (en)
CS (1) CS155970B2 (en)
DE (4) DE1933301A1 (en)
DK (1) DK128421B (en)
ES (4) ES363592A1 (en)
FI (1) FI47109C (en)
FR (2) FR2001977A1 (en)
IE (1) IE32962B1 (en)
IT (1) IT1061759B (en)
NL (1) NL158547B (en)
NO (3) NO131388C (en)
SE (3) SE382990B (en)
SU (1) SU404195A3 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1357317A (en) * 1970-08-27 1974-06-19 Beecham Group Ltd Enzymes
IL39158A (en) * 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
BE791748A (en) * 1971-11-23 1973-05-22 Bayer Ag PROCESS FOR THE PRODUCTION OF 6-AMINOPENICILLANIC ACID BY ENZYMATIC RUPTURE OF PENICILLINS
JPS5420193A (en) * 1977-07-12 1979-02-15 Tanabe Seiyaku Co Ltd Immobilized aminoacylase and its preparation
GB9718740D0 (en) 1997-09-05 1997-11-12 Advanced Phytonics Ltd Improvements in or relating to the preparation of a compound
DE10123048A1 (en) * 2001-05-11 2002-11-21 Bermatingen Maschf Cutter for rotary mower and mulcher comprises central mounting attached to drive shaft, cutter blades being attached to sloping mounting arms which are bolted to underside of central mounting

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB877898A (en) * 1956-12-06 1961-09-20 Apv Co Ltd A new or improved method of liberating enzymes
GB1118566A (en) * 1964-11-25 1968-07-03 Beecham Group Ltd Production of 6-aminopenicillanic acid

Also Published As

Publication number Publication date
NL158547B (en) 1978-11-15
FR2001977B1 (en) 1974-08-30
DE1966427C3 (en) 1980-03-13
FI47109B (en) 1973-05-31
ES384026A1 (en) 1973-04-16
NO131386B (en) 1975-02-10
BE727506A (en) 1969-07-01
DE1966427B2 (en) 1979-07-12
CH523320A (en) 1972-05-31
IE32962B1 (en) 1974-02-06
DE1966428C3 (en) 1978-03-02
IT1061759B (en) 1983-04-30
CA941769A (en) 1974-02-12
NO131388B (en) 1975-02-10
CH538540A (en) 1973-08-15
FI47109C (en) 1973-09-10
SE400291B (en) 1978-03-20
FR2081316B1 (en) 1974-08-30
DE1966428B2 (en) 1977-07-21
NO131388C (en) 1975-05-21
ES384025A1 (en) 1973-04-16
DE1966427A1 (en) 1972-08-24
SE382990B (en) 1976-02-23
SU404195A3 (en) 1973-10-26
SE352643B (en) 1973-01-08
FR2081316A1 (en) 1971-12-03
AT297218B (en) 1972-03-10
NO131386C (en) 1975-05-21
CS155970B2 (en) 1974-06-24
JPS4833386B1 (en) 1973-10-13
NO131387B (en) 1975-02-10
FR2001977A1 (en) 1969-10-03
DE1966428A1 (en) 1972-09-14
AT300198B (en) 1972-07-10
IE32962L (en) 1969-08-15
ES363592A1 (en) 1970-12-16
DE1933301A1 (en) 1970-06-25
DE1907365A1 (en) 1969-09-11
NL6902045A (en) 1969-08-19
NO131387C (en) 1975-05-21
ES384027A1 (en) 1973-06-01
JPS5622278B1 (en) 1981-05-23

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