FI97891B - Förfarande för framställning av acylderivat av 2'-deoxiguanocin - Google Patents

Förfarande för framställning av acylderivat av 2'-deoxiguanocin

Info

Publication number
FI97891B
FI97891B FI941245A FI941245A FI97891B FI 97891 B FI97891 B FI 97891B FI 941245 A FI941245 A FI 941245A FI 941245 A FI941245 A FI 941245A FI 97891 B FI97891 B FI 97891B
Authority
FI
Finland
Prior art keywords
acyl derivatives
deoxyguanocin
preparation
enhancing
haematopoesis
Prior art date
Application number
FI941245A
Other languages
English (en)
Finnish (fi)
Other versions
FI941245A (sv
FI941245A0 (sv
FI97891C (sv
Inventor
Borstel Reid Warren Von
Michael Kevin Bamat
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of FI941245A publication Critical patent/FI941245A/sv
Publication of FI941245A0 publication Critical patent/FI941245A0/sv
Publication of FI97891B publication Critical patent/FI97891B/sv
Application granted granted Critical
Publication of FI97891C publication Critical patent/FI97891C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
FI941245A 1987-10-28 1994-03-16 Förfarande för framställning av acylderivat av 2'-deoxiguanocin FI97891C (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11592387A 1987-10-28 1987-10-28
US11592387 1987-10-28
PCT/US1988/003824 WO1989003838A1 (en) 1987-10-28 1988-10-27 Acyl deoxyribonucleoside derivatives and uses thereof
US8803824 1988-10-27
FI893100A FI91764C (sv) 1987-10-28 1989-06-26 Analogiförfarande för framställning av acyldeoxiribonucleosidderivat
FI893100 1989-06-26

Publications (4)

Publication Number Publication Date
FI941245A FI941245A (sv) 1994-03-16
FI941245A0 FI941245A0 (sv) 1994-03-16
FI97891B true FI97891B (sv) 1996-11-29
FI97891C FI97891C (sv) 1997-03-10

Family

ID=22364166

Family Applications (2)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (sv) 1987-10-28 1989-06-26 Analogiförfarande för framställning av acyldeoxiribonucleosidderivat
FI941245A FI97891C (sv) 1987-10-28 1994-03-16 Förfarande för framställning av acylderivat av 2'-deoxiguanocin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (sv) 1987-10-28 1989-06-26 Analogiförfarande för framställning av acyldeoxiribonucleosidderivat

Country Status (15)

Country Link
US (1) US6020320A (sv)
EP (2) EP0355131B1 (sv)
JP (2) JP2637534B2 (sv)
KR (1) KR890701609A (sv)
AT (2) ATE243039T1 (sv)
CA (1) CA1329932C (sv)
DE (2) DE3856557T2 (sv)
DK (1) DK174400B1 (sv)
FI (2) FI91764C (sv)
HK (1) HK1004854A1 (sv)
IL (1) IL88204A (sv)
IN (1) IN167609B (sv)
NO (1) NO174392C (sv)
WO (1) WO1989003838A1 (sv)
ZA (1) ZA888083B (sv)

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US6329350B1 (en) * 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
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US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
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TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
DK1572095T3 (en) 2002-09-13 2015-09-14 Novartis Ag BETA-L-2'-DEOXYNUCLEOTIDES FOR TREATMENT OF RESISTANT HBV STANDS AND COMBINATION THERAPIES
US9186406B2 (en) 2007-08-16 2015-11-17 The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. Compositions containing nucleosides and manganese and their uses
GB2480028B (en) * 2009-02-04 2013-07-10 Univ Georgia Methods of inhibiting fibrogenesis and treating fibrotic disease
CN102946888B (zh) 2010-04-29 2018-07-31 亨利·M·杰克逊军事医学促进基金会 含有嘌呤和嘧啶核苷、肽和锰的组合物及其用途
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Also Published As

Publication number Publication date
FI941245A (sv) 1994-03-16
NO892642D0 (no) 1989-06-26
DK318089D0 (da) 1989-06-27
NO174392B (no) 1994-01-17
DE3855513D1 (de) 1996-10-10
DK174400B1 (da) 2003-02-10
ATE243039T1 (de) 2003-07-15
FI91764B (sv) 1994-04-29
ZA888083B (en) 1990-06-27
JP2764014B2 (ja) 1998-06-11
FI941245A0 (sv) 1994-03-16
IL88204A0 (en) 1989-06-30
US6020320A (en) 2000-02-01
DE3856557T2 (de) 2004-06-03
ATE142221T1 (de) 1996-09-15
DE3856557D1 (de) 2003-07-24
JPH02500373A (ja) 1990-02-08
IL88204A (en) 1996-06-18
JP2637534B2 (ja) 1997-08-06
EP0355131A1 (en) 1990-02-28
CA1329932C (en) 1994-05-31
NO892642L (no) 1989-08-24
FI97891C (sv) 1997-03-10
DE3855513T2 (de) 1997-01-09
EP0712629B1 (en) 2003-06-18
IN167609B (sv) 1990-11-24
EP0355131A4 (en) 1990-12-05
JPH07267981A (ja) 1995-10-17
NO174392C (no) 1994-04-27
KR890701609A (ko) 1989-12-21
EP0355131B1 (en) 1996-09-04
DK318089A (da) 1989-08-28
FI893100A (sv) 1989-06-26
EP0712629A1 (en) 1996-05-22
WO1989003838A1 (en) 1989-05-05
HK1004854A1 (en) 1998-12-11
FI91764C (sv) 1994-08-10
FI893100A0 (sv) 1989-06-26

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