FI97295B - Förfarande för framställning av nya terapeutiskt användbara pyridazinonderivat - Google Patents
Förfarande för framställning av nya terapeutiskt användbara pyridazinonderivat Download PDFInfo
- Publication number
- FI97295B FI97295B FI893345A FI893345A FI97295B FI 97295 B FI97295 B FI 97295B FI 893345 A FI893345 A FI 893345A FI 893345 A FI893345 A FI 893345A FI 97295 B FI97295 B FI 97295B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- alkyl
- compound
- methyl
- thien
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (4)
1. Förfarande för framställning av nya terapeutiskt användbara pyridazinonderivat med formeln I och farmaceu-5 tiskt godtagbara salter därav, H i vilken formel R1 betecknar 1-4 substituenter, sora kan vara lika 15 eller olika och sora är valda ur gruppen H, OH, halogen, NOj, icke-substituerad eller C^-alkylsubstituerad amino, C^-alkyl, halogensubstltuerad C^-alkyl, 0-ALK-NR4R5 och C1.4-alkoxi, varvid tvä substituenter tillsammans även kan bilda en metylendioxigrupp,
20 R2 och R3 betecknar oberoende av varandra väte eller C^-alkyl, R* och R5 betecknar oberoende av varandra väte eller C1.4-alkyl, eller de bildar tillsammans med kväveatomen, tili vilken de är bundna, en 5- eller 6-ledad ring,
25 X är S eller 0, och den streckade linjen betecknar en eventuell bind-ning, kännetecknat därav, att en ketosyra med formeln 30 1 -xCs. ^ R2 r3 Jk Jk» ^COOH (III) o 1 där R1, R2, R3, X och den streckade linjen betecknar samma 23 97255 som ovan, eller en C^g-alkyester eller ett karboxylsyrasalt därav, kondenseras med hydrazin, företrädesvis dess hyd-rat, varefter, om sä önskas, en erhällen förening med for-meln I, där den streckade linjen ej betecknar en bindning, 5 oxideras, varvid erhälls en förening med formeln I, där den streckade linjen betecknar en bindning, och/eller en förening med formeln I behandlas med ett reagens för om-vandlande av substituenten R1 tili en annan R1-substituent, och/eller föreningen med formeln I behandlas med en orga-10 nisk eller oorganisk syra för erhällande av ett farmaceu-tiskt godtagbart sait.
2. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man framställer en förening med formeln I, där R1 är OH, halogen, C^-alkoxi eller 0-ALK-15 NR4R5 och R2 och R3 betecknar väte eller metyl, varvid föreningen har 2, 3 eller 4 R1-substituenter, som kan varav lika eller olika.
3. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man framställer en förening med 20 formeln I, där R1 är OH, F, Cl, Br, 0CH3, OC2H5, 2-(piperi-din-l-yl)etyloxi eller 2-(piperidin-l-yl)propyloxi, R2 är H, R3 är CH3 och X är S, varvid föreningen har 2 eller 3 R1-substituenter, som kan vara lika eller olka, och den streckade linjen betecknar ej en bindning. 25
4. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man framställer en förening med formeln H eller ett farmaceutiskt godtagbart sait därav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88306295 | 1988-07-11 | ||
| EP88306295 | 1988-07-11 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI893345A0 FI893345A0 (sv) | 1989-07-10 |
| FI893345A FI893345A (sv) | 1990-01-12 |
| FI97295B true FI97295B (sv) | 1996-08-15 |
| FI97295C FI97295C (sv) | 1996-11-25 |
Family
ID=8200131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI893345A FI97295C (sv) | 1988-07-11 | 1989-07-10 | Förfarande för framställning av nya terapeutiskt användbara pyridazinonderivat |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4952571A (sv) |
| EP (1) | EP0350990B1 (sv) |
| JP (1) | JPH0285281A (sv) |
| KR (1) | KR900001691A (sv) |
| AT (1) | ATE128135T1 (sv) |
| AU (1) | AU617489B2 (sv) |
| CA (1) | CA1308413C (sv) |
| DE (1) | DE68924308T2 (sv) |
| DK (1) | DK340889A (sv) |
| ES (1) | ES2080064T3 (sv) |
| FI (1) | FI97295C (sv) |
| GR (1) | GR3018356T3 (sv) |
| IE (1) | IE68680B1 (sv) |
| NZ (1) | NZ229876A (sv) |
| PT (1) | PT91117B (sv) |
| ZA (1) | ZA895087B (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94394A (en) * | 1989-05-17 | 1994-10-21 | Nissan Chemical Ind Ltd | History of pyridazinone, process for their preparation and preparations for controlling and / or preventing insects, mites, nematodes and mollusks |
| KR100226053B1 (ko) * | 1996-06-18 | 1999-10-15 | 권태웅 | 공장제어 시스템의 비데오 카피어 인터페이스 모듈 |
| US6276721B1 (en) * | 2000-03-14 | 2001-08-21 | Simula, Inc. | Pivoting seat belt upper anchor point attachment |
| FR2829977B1 (fr) * | 2001-09-24 | 2003-12-12 | Valeo Vision | Projecteur d'eclairage ou de signalisation a controleur integre pour vehicule et systeme d'eclairage ou de signalisation equipe d'au moins un tel projecteur |
| PT3523287T (pt) * | 2016-10-04 | 2021-10-06 | Merck Sharp & Dohme | Compostos de benzo[b]tiofeno como agonistas de sting |
| RU2020109328A (ru) | 2017-08-04 | 2021-09-06 | Мерк Шарп И Доум Корп. | Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака |
| JP2020530838A (ja) * | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | がん治療のためのベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニスト |
| BR112020020085A8 (pt) * | 2018-04-03 | 2023-04-11 | Merck Sharp & Dohme | Composto, composição farmacêutica, e, métodos para induzir uma resposta imune, para induzir produção de interferons de tipo i dependentes de sting e para tratar um distúrbio de proliferação celular |
| WO2019195063A1 (en) * | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
| CN113861161A (zh) * | 2020-06-30 | 2021-12-31 | 上海海和药物研究开发股份有限公司 | 一种芳基并芳杂环衍生物及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES482789A0 (es) * | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| US4225711A (en) * | 1978-10-02 | 1980-09-30 | Schering Corporation | Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants |
| DE3129447A1 (de) * | 1981-07-25 | 1983-02-10 | Dr. Karl Thomae Gmbh, 7950 Biberach | "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel" |
| CA1199027A (en) * | 1981-11-12 | 1986-01-07 | Stuart D. Mills | Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone |
| US4666902A (en) * | 1983-06-20 | 1987-05-19 | Cassella Aktiengesellschaft | Tetrahydropyridazinone derivatives, processes for their preparation and their use |
| US4647564A (en) * | 1984-05-14 | 1987-03-03 | Eli Lilly And Company | Inotropic agents |
| DE3511110A1 (de) * | 1985-03-27 | 1986-10-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE3631085A1 (de) * | 1986-09-12 | 1988-03-24 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte |
-
1989
- 1989-06-29 ES ES89201716T patent/ES2080064T3/es not_active Expired - Lifetime
- 1989-06-29 AT AT89201716T patent/ATE128135T1/de not_active IP Right Cessation
- 1989-06-29 EP EP89201716A patent/EP0350990B1/en not_active Expired - Lifetime
- 1989-06-29 DE DE68924308T patent/DE68924308T2/de not_active Expired - Fee Related
- 1989-07-03 IE IE214889A patent/IE68680B1/en not_active IP Right Cessation
- 1989-07-04 ZA ZA895087A patent/ZA895087B/xx unknown
- 1989-07-07 AU AU37967/89A patent/AU617489B2/en not_active Ceased
- 1989-07-07 NZ NZ229876A patent/NZ229876A/en unknown
- 1989-07-10 CA CA000605216A patent/CA1308413C/en not_active Expired - Fee Related
- 1989-07-10 PT PT91117A patent/PT91117B/pt not_active IP Right Cessation
- 1989-07-10 FI FI893345A patent/FI97295C/sv not_active IP Right Cessation
- 1989-07-10 DK DK340889A patent/DK340889A/da not_active Application Discontinuation
- 1989-07-10 JP JP1177872A patent/JPH0285281A/ja active Pending
- 1989-07-10 KR KR1019890009773A patent/KR900001691A/ko not_active Application Discontinuation
- 1989-07-11 US US07/378,342 patent/US4952571A/en not_active Expired - Fee Related
-
1995
- 1995-12-11 GR GR950403477T patent/GR3018356T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA895087B (en) | 1990-03-28 |
| IE68680B1 (en) | 1996-07-10 |
| ES2080064T3 (es) | 1996-02-01 |
| DE68924308D1 (de) | 1995-10-26 |
| EP0350990B1 (en) | 1995-09-20 |
| PT91117B (pt) | 1995-07-06 |
| GR3018356T3 (en) | 1996-03-31 |
| IE892148L (en) | 1990-01-11 |
| EP0350990A1 (en) | 1990-01-17 |
| DK340889A (da) | 1990-01-12 |
| US4952571A (en) | 1990-08-28 |
| DE68924308T2 (de) | 1996-04-04 |
| NZ229876A (en) | 1991-03-26 |
| JPH0285281A (ja) | 1990-03-26 |
| FI893345A0 (sv) | 1989-07-10 |
| FI893345A (sv) | 1990-01-12 |
| KR900001691A (ko) | 1990-02-27 |
| DK340889D0 (da) | 1989-07-10 |
| AU3796789A (en) | 1990-01-11 |
| FI97295C (sv) | 1996-11-25 |
| AU617489B2 (en) | 1991-11-28 |
| PT91117A (pt) | 1990-02-08 |
| ATE128135T1 (de) | 1995-10-15 |
| CA1308413C (en) | 1992-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: AKZO N.V. |