FI97226B - Förfarande för framställning av terapeutiskt användbara 6-amino-substituerade oktahydro-1,7,8-indolizintriolderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 6-amino-substituerade oktahydro-1,7,8-indolizintriolderivat Download PDF

Info

Publication number
FI97226B
FI97226B FI925260A FI925260A FI97226B FI 97226 B FI97226 B FI 97226B FI 925260 A FI925260 A FI 925260A FI 925260 A FI925260 A FI 925260A FI 97226 B FI97226 B FI 97226B
Authority
FI
Finland
Prior art keywords
give
octahydro
indolizine
formula
amino
Prior art date
Application number
FI925260A
Other languages
English (en)
Finnish (fi)
Other versions
FI97226C (sv
FI925260A0 (sv
FI925260A (sv
Inventor
Paul Sai-Ho Liu
Mohinder Singh Kang
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI925260A0 publication Critical patent/FI925260A0/sv
Publication of FI925260A publication Critical patent/FI925260A/sv
Application granted granted Critical
Publication of FI97226B publication Critical patent/FI97226B/sv
Publication of FI97226C publication Critical patent/FI97226C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Claims (2)

1. Förfarande för framställning av terapeutlskt användbara 6-amino-substituerade oktahydro-1,7,8-indoli- 5 zlntrlolderlvat med formeIn R"0 V/\ . NHR OR ’ väri R är C^-alkanoyl; och R', R" och R” ’ oberoende av 15 varandra betecknar väte, C^Q-alkanoyl eller bensoyl, kännetecknat av, att 6-amino-oktahydroindo-lizin med formeln HO 20 \-N HO / \ \ / (II) OH nh2 25 « bringas att reagera med en syraanhydrid med formeln R20, väri R är ovan definierad, i närvaro av vatten, varvid en amid med formeln I erhälls, vilken därefter, om sä önskas, bringas att reagera med samma syraanhydrid under vatten-30 fria förhällanden, varvid estrar med formeln I erhälls.
2. Förfarande enligt patentkrav 1, kännetecknat av, att [lS-(la,68,7a,86,8aB)-6-acetamido-oktahydro-1,7,8-indolizintriol framställs. il . liri Mb l i * tt :
FI925260A 1990-06-04 1992-11-19 Förfarande för framställning av terapeutiskt användbara 6-amino-substituerade oktahydro-1,7,8-indolizintriolderivat FI97226C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53252290 1990-06-04
US07/532,522 US5079254A (en) 1990-06-04 1990-06-04 Derivatives of 6-aminooctahydroindolizinetriol
US9103179 1991-05-08
PCT/US1991/003179 WO1991018598A1 (en) 1990-06-04 1991-05-08 Derivatives of 6-aminooctahydroindolizinetriol

Publications (4)

Publication Number Publication Date
FI925260A0 FI925260A0 (sv) 1992-11-19
FI925260A FI925260A (sv) 1992-11-19
FI97226B true FI97226B (sv) 1996-07-31
FI97226C FI97226C (sv) 1996-11-11

Family

ID=24122149

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925260A FI97226C (sv) 1990-06-04 1992-11-19 Förfarande för framställning av terapeutiskt användbara 6-amino-substituerade oktahydro-1,7,8-indolizintriolderivat

Country Status (15)

Country Link
US (1) US5079254A (sv)
EP (1) EP0532530B1 (sv)
JP (1) JP3019265B2 (sv)
KR (1) KR100195421B1 (sv)
AT (1) ATE155685T1 (sv)
AU (1) AU641771B2 (sv)
CA (1) CA2082820C (sv)
DE (1) DE69126978T2 (sv)
DK (1) DK0532530T3 (sv)
ES (1) ES2106080T3 (sv)
FI (1) FI97226C (sv)
GR (1) GR3025044T3 (sv)
HU (1) HU212579B (sv)
NO (1) NO300686B1 (sv)
WO (1) WO1991018598A1 (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013538A1 (en) * 1993-11-12 1995-05-18 Operon Technologies, Inc. Methods of producing and screening complex chemical libraries
AU1562895A (en) * 1994-01-12 1995-08-01 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors
CA2526173A1 (en) * 2003-05-22 2004-12-02 The Hospital For Sick Children Treatment of tay sachs or sandhoff diseases by enhancing hexosaminidase activity
CA2553866A1 (en) * 2004-01-20 2005-08-11 Optimer Pharmaceuticals, Inc. Treatment of degenerative cartilage conditions in a mammal with glycosi dase inhibitors
KR100858512B1 (ko) 2007-03-29 2008-09-12 포항공과대학교 산학협력단 헥소스아미니데이즈 활성 저해 방법
JP2011529857A (ja) * 2008-08-01 2011-12-15 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼインヒビターおよびその使用
MY165728A (en) 2010-12-23 2018-04-20 Merck Sharp & Dohme Selective glycosidase inhibitors and uses thereof
WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2726492B1 (en) 2011-06-27 2017-11-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
WO2014032185A1 (en) 2012-08-31 2014-03-06 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
BR112015009638A2 (pt) 2012-10-31 2017-07-04 Alectos Therapeutics Inc inibidores de glicosidase e usos dos mesmos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973519A (ja) * 1982-09-17 1984-04-25 Fujisawa Pharmaceut Co Ltd スワインソニンの製造法およびそれを含む免疫調整剤
GB8429810D0 (en) * 1984-11-26 1985-01-03 Fujisawa Pharmaceutical Co Indolizidine derivatives
JPS61277685A (ja) * 1985-05-31 1986-12-08 Fujisawa Pharmaceut Co Ltd 新規インドリジジン誘導体、その製造法およびそれを含有する組成物
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
CA1315276C (en) * 1987-07-02 1993-03-30 Paul S. Liu Castanospermine esters and glycosides
JPH01129182A (ja) * 1987-11-16 1989-05-22 Tokyo Keiki Co Ltd 波動伝搬時間測定装置
JPH01277685A (ja) * 1988-04-28 1989-11-08 Hitachi Ltd ピストンポンプ

Also Published As

Publication number Publication date
JPH05507474A (ja) 1993-10-28
ATE155685T1 (de) 1997-08-15
WO1991018598A1 (en) 1991-12-12
KR930700502A (ko) 1993-03-15
FI97226C (sv) 1996-11-11
GR3025044T3 (en) 1998-01-30
EP0532530A1 (en) 1993-03-24
HU9203829D0 (en) 1993-03-29
JP3019265B2 (ja) 2000-03-13
CA2082820A1 (en) 1991-12-05
FI925260A0 (sv) 1992-11-19
ES2106080T3 (es) 1997-11-01
EP0532530A4 (en) 1993-05-26
AU641771B2 (en) 1993-09-30
AU7874391A (en) 1991-12-31
DK0532530T3 (da) 1997-08-25
CA2082820C (en) 2002-01-22
HUT62585A (en) 1993-05-28
HU212579B (en) 1996-08-29
EP0532530B1 (en) 1997-07-23
DE69126978T2 (de) 1997-11-27
NO924670L (no) 1992-12-03
KR100195421B1 (ko) 1999-06-15
NO300686B1 (no) 1997-07-07
FI925260A (sv) 1992-11-19
US5079254A (en) 1992-01-07
DE69126978D1 (de) 1997-08-28
NO924670D0 (no) 1992-12-03

Similar Documents

Publication Publication Date Title
FI97226B (sv) Förfarande för framställning av terapeutiskt användbara 6-amino-substituerade oktahydro-1,7,8-indolizintriolderivat
FI106028B (sv) Förfarande för framställning av terapeutiskt användbara bicykliska geldanamysinderivat
KR20150000901A (ko) 히스톤 탈아세틸효소(hdacs) 억제제
KR20130120517A (ko) 암을 치료하기 위한 hdac 억제제로서 4-아미노-n-하이드록시-벤즈아미드
EA012295B1 (ru) Конденсированные пирролокарбазолы
Ferlin et al. Pyrrolo-quinoline derivatives as potential antineoplastic drugs
EP3612180B1 (en) Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel tmem16a
Hu et al. Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4. beta.-(arylamino)-4'-O-demethylpodophyllotoxins
TW201011034A (en) New (poly) aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents
US5332811A (en) Etopside analogs
US6362218B1 (en) Brefeldin A derivatives
Zhou et al. Semisynthesis and antitumor activities of new styryl-lactone derivatives
DE69202173T2 (de) Phenylethanolamino- und Phenylethanolaminomethyltetraline, Verfahren zu deren Herstellung Zwischenprodukte davon und diese enthaltende pharmazeutische Zusammensetzungen.
DE69019217T2 (de) Perylenquinon (UCN-1028D)-Derivate.
CN113527195B (zh) 一类5-芳基烟酰胺类lsd1/hdac双靶点抑制剂、其制备方法及应用
US5696119A (en) (2-quinoxalinyloxy) phenoxypropanoic acids and related derivatives as anticancer agents
OHTSUKA et al. Hispidospermidin, a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127 II. Isolation, characterization and structural elucidation
CN111393500B (zh) 具有共轭二烯结构c环的齐墩果酸衍生物及其制备方法和应用
Donati et al. Conformationally constrained tryptophan analogs. Synthesis of (±)-(Z)-and (±)-(E)-2-amino-2, 3-methano-3-(indol-3-yl)-propanoic acids
US4895854A (en) Antitumor alkaloids
DE69624236T2 (de) Ausgewählte lösliche ester von indolcarbazolen die hydroxyl enthalten
KR20000057268A (ko) 나프티리딘 유도체
CN115353522B (zh) 淫羊藿素-去甲斑蝥素缀合物的区域选择性合成及抗肿瘤应用
CN114195676B (zh) 双芳基肼类化合物及其加合物和在制备抗肿瘤药物中的应用
FI85140B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-(1h-indol-4-yl)-bensamidderivat.

Legal Events

Date Code Title Description
BB Publication of examined application
MA Patent expired