FI962866A0 - Förfarande för framställning av S(+)-ibuprofen-partiklar - Google Patents

Förfarande för framställning av S(+)-ibuprofen-partiklar

Info

Publication number
FI962866A0
FI962866A0 FI962866A FI962866A FI962866A0 FI 962866 A0 FI962866 A0 FI 962866A0 FI 962866 A FI962866 A FI 962866A FI 962866 A FI962866 A FI 962866A FI 962866 A0 FI962866 A0 FI 962866A0
Authority
FI
Finland
Prior art keywords
pct
ibuprofen
particles
tablets
sec
Prior art date
Application number
FI962866A
Other languages
English (en)
Finnish (fi)
Other versions
FI112030B (sv
FI962866A (sv
Inventor
Torsten Moeller
Gerhard Hantich
Ernst Hesse
Original Assignee
Gebro Broschek Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gebro Broschek Gmbh filed Critical Gebro Broschek Gmbh
Publication of FI962866A0 publication Critical patent/FI962866A0/sv
Publication of FI962866A publication Critical patent/FI962866A/sv
Application granted granted Critical
Publication of FI112030B publication Critical patent/FI112030B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyurethanes Or Polyureas (AREA)
FI962866A 1994-01-28 1996-07-16 Förfarande för framställning av S(+)-ibuprofen-partiklar FI112030B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT0015894A AT401871B (de) 1994-01-28 1994-01-28 Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
AT15894 1994-01-28
PCT/AT1995/000014 WO1995020382A1 (de) 1994-01-28 1995-01-26 Verfahren zur herstellung von s(+)-ibuprofen-partikeln
AT9500014 1995-01-26

Publications (3)

Publication Number Publication Date
FI962866A0 true FI962866A0 (sv) 1996-07-16
FI962866A FI962866A (sv) 1996-07-16
FI112030B FI112030B (sv) 2003-10-31

Family

ID=3483086

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962866A FI112030B (sv) 1994-01-28 1996-07-16 Förfarande för framställning av S(+)-ibuprofen-partiklar

Country Status (20)

Country Link
US (1) US5869101A (sv)
EP (1) EP0741565B1 (sv)
JP (1) JP2840132B2 (sv)
AT (2) AT401871B (sv)
AU (1) AU689531B2 (sv)
CA (1) CA2181810C (sv)
CZ (1) CZ287998B6 (sv)
DE (1) DE59508198D1 (sv)
DK (1) DK0741565T3 (sv)
ES (1) ES2146744T3 (sv)
FI (1) FI112030B (sv)
GR (1) GR3033841T3 (sv)
HU (1) HU217798B (sv)
NO (1) NO313982B1 (sv)
NZ (1) NZ278551A (sv)
PL (1) PL179095B1 (sv)
PT (1) PT741565E (sv)
SI (1) SI9520030A (sv)
SK (1) SK282433B6 (sv)
WO (1) WO1995020382A1 (sv)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225402B (en) 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
CA2364342C (en) 1999-04-01 2011-02-01 Dsm N.V. Agglomerates by crystallisation
ES2263510T3 (es) * 1999-12-09 2006-12-16 Reckitt Benckiser Healthcare (Uk) Limited Preparacion en comprimidos que comprende un antiinflamatorio no esteroideo (aine).
KR100700721B1 (ko) * 2000-09-08 2007-03-27 지상철 안정성 및 용출율이 향상된 ｓ(+)-이부프로펜의 정제
GB0113839D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
JP2007513143A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 押出機を使用して好ましくはポロクサマーおよびグリセリドを含む多粒子アジスロマイシン組成物を製造するための噴霧凝固法
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
EP1691786A1 (en) * 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
EP1694304A2 (en) * 2003-12-04 2006-08-30 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
SI1691787T1 (sl) * 2003-12-04 2008-10-31 Pfizer Prod Inc Postopek za pripravo farmacevtskih produktov iz več delcev
CZ297830B6 (cs) * 2005-08-30 2007-04-11 I.Q.A., A. S. Zpusob výroby jemne krystalické smesi obsahující nesteroidní protizánetlivé lécivo, jemne krystalická smes pripravitelná tímto zpusobem a pevný farmaceutický prostredek tuto smes obsahující
CN105963259A (zh) * 2016-05-25 2016-09-28 山东理工大学 一种采用常压过滤制备布洛芬微球的方法
CN109956860B (zh) * 2019-03-08 2022-03-01 天津大学 一种布洛芬球形晶体的制备方法
CN110041191A (zh) * 2019-04-30 2019-07-23 湖南九典宏阳制药有限公司 一种培比洛芬的纯化方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
JPS52111533A (en) * 1976-03-12 1977-09-19 Kanebo Ltd Preparation of fine powder of ibuprophene
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4609675A (en) * 1984-08-17 1986-09-02 The Upjohn Company Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
DE3669103D1 (de) * 1986-11-14 1990-04-05 Puetter Medice Chem Pharm Ibuprofen enthaltendes arzneimittel.
GB8716975D0 (en) * 1987-07-17 1987-08-26 Boots Co Plc Therapeutic agents
US5198568A (en) * 1988-04-07 1993-03-30 Sepracor, Inc. Compounds useful in enzymatic resolution systems and their preparation
DE3833446A1 (de) * 1988-10-01 1990-04-05 Hoechst Ag Verfahren zur herstellung von arzneimittelwirkstoff-partikeln mit verbesserten fliess-, lager- und formulierungseigenschaften sowie arzneimittel, die diese arzneimittelwirkstoff-partikeln enthalten
DE3833448A1 (de) * 1988-10-01 1990-04-12 Hoechst Ag Verfahren zur gewinnung von ibuprofen fuer die direkttablettierung
DE68907062T2 (de) * 1988-10-05 1993-10-07 Upjohn Co Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel.
JPH082781B2 (ja) * 1988-10-18 1996-01-17 嘉明 川島 中空顆粒状医薬及びその製法
US5104656A (en) * 1989-06-16 1992-04-14 Seth Pyare L Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent
WO1992008686A1 (en) * 1990-11-19 1992-05-29 Ethyl Corporation Process for improving flow characteristics of crystalline ibuprofen
DE4122591C1 (en) * 1991-07-08 1993-02-18 Roland 8012 Ottobrunn De Bodmeier Producing microcapsules of water insoluble polymer and active agent - includes dissolving or dispersing active agent in aq. polymer contg. gellable assistants
US5191114A (en) * 1991-10-09 1993-03-02 Sage Pharmaceuticals, Inc. Process for enhancing the flow characteristics of ibuprofen
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel

Also Published As

Publication number Publication date
ES2146744T3 (es) 2000-08-16
AT401871B (de) 1996-12-27
FI112030B (sv) 2003-10-31
PL315655A1 (en) 1996-11-25
ATE191848T1 (de) 2000-05-15
JP2840132B2 (ja) 1998-12-24
CZ287998B6 (cs) 2001-03-14
FI962866A (sv) 1996-07-16
EP0741565B1 (de) 2000-04-19
WO1995020382A1 (de) 1995-08-03
DE59508198D1 (de) 2000-05-25
NZ278551A (en) 1997-10-24
US5869101A (en) 1999-02-09
DK0741565T3 (da) 2000-09-04
SK282433B6 (sk) 2002-02-05
CA2181810C (en) 2000-10-24
AU1449995A (en) 1995-08-15
HU9602013D0 (en) 1996-09-30
SK96496A3 (en) 1997-01-08
GR3033841T3 (en) 2000-10-31
PT741565E (pt) 2000-09-29
NO313982B1 (no) 2003-01-13
PL179095B1 (pl) 2000-07-31
ATA15894A (de) 1996-05-15
EP0741565A1 (de) 1996-11-13
JPH09503522A (ja) 1997-04-08
NO962966L (no) 1996-07-15
CZ213196A3 (en) 1996-10-16
NO962966D0 (no) 1996-07-15
HU217798B (hu) 2000-04-28
SI9520030A (en) 1996-12-31
HUT74853A (en) 1997-02-28
AU689531B2 (en) 1998-04-02

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