FI960303A0 - D-vitamiinianalogeja - Google Patents
D-vitamiinianalogejaInfo
- Publication number
- FI960303A0 FI960303A0 FI960303A FI960303A FI960303A0 FI 960303 A0 FI960303 A0 FI 960303A0 FI 960303 A FI960303 A FI 960303A FI 960303 A FI960303 A FI 960303A FI 960303 A0 FI960303 A0 FI 960303A0
- Authority
- FI
- Finland
- Prior art keywords
- alpha
- azide
- optionally substituted
- group
- vitamin
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
- 235000019166 vitamin D Nutrition 0.000 title abstract 2
- 239000011710 vitamin D Substances 0.000 title abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
- 229940046008 vitamin d Drugs 0.000 title abstract 2
- 150000001540 azides Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- -1 cyclohexylidene moiety Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939315253A GB9315253D0 (en) | 1993-07-23 | 1993-07-23 | Chemical compounds |
| GB9315253 | 1993-07-23 | ||
| GB9401587 | 1994-07-22 | ||
| PCT/GB1994/001587 WO1995003273A1 (en) | 1993-07-23 | 1994-07-22 | Vitamin d analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI960303A0 true FI960303A0 (fi) | 1996-01-22 |
| FI960303A FI960303A (fi) | 1996-03-22 |
| FI113535B FI113535B (fi) | 2004-05-14 |
Family
ID=10739292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI960303A FI113535B (fi) | 1993-07-23 | 1996-01-22 | Menetelmä terapeuttisesti käyttökelpoisten D-vitamiinianalogien valmistamiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5872140A (fi) |
| EP (1) | EP0710227B1 (fi) |
| JP (1) | JPH09500637A (fi) |
| KR (1) | KR100321415B1 (fi) |
| CN (1) | CN1043883C (fi) |
| AT (1) | ATE172451T1 (fi) |
| AU (1) | AU690565B2 (fi) |
| CA (1) | CA2167837A1 (fi) |
| CZ (1) | CZ20796A3 (fi) |
| DE (1) | DE69414115T2 (fi) |
| DK (1) | DK0710227T3 (fi) |
| ES (1) | ES2125466T3 (fi) |
| FI (1) | FI113535B (fi) |
| GB (1) | GB9315253D0 (fi) |
| HU (1) | HU221597B (fi) |
| IL (1) | IL110415A (fi) |
| NO (1) | NO314453B1 (fi) |
| NZ (1) | NZ268659A (fi) |
| WO (1) | WO1995003273A1 (fi) |
| ZA (1) | ZA945427B (fi) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| EP1220676B1 (en) | 1999-09-29 | 2005-05-04 | Colotech A/S | Prevention of colorectal cancer |
| US6703380B2 (en) | 1999-09-29 | 2004-03-09 | Colotech A/S | Prevention of cancer |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6555573B2 (en) * | 2000-12-21 | 2003-04-29 | The Quigley Corporation | Method and composition for the topical treatment of diabetic neuropathy |
| US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030105031A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Methods for the treatment of skin disorders |
| US20030118536A1 (en) * | 2001-11-06 | 2003-06-26 | Rosenbloom Richard A. | Topical compositions and methods for treatment of adverse effects of ionizing radiation |
| US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
| ES2347045T3 (es) * | 2002-11-04 | 2010-10-25 | Ocean Nutrition Canada Limited | Microcapsulas que tienen multiples cortezas, y metodo para su preparacion. |
| US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
| US8034450B2 (en) * | 2005-01-21 | 2011-10-11 | Ocean Nutrition Canada Limited | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
| EP1848729A2 (en) * | 2005-01-27 | 2007-10-31 | Ocean Nutrition Canada Limited | Chromium-fatty acid compounds and methods of making and using thereof |
| DE602006011127D1 (de) * | 2005-01-27 | 2010-01-28 | Ocean Nutrition Canada Ltd | Fettsäure-benzenediol-derivate sowie herstellungs- und verwendungsverfahren dafür |
| US9968120B2 (en) * | 2006-05-17 | 2018-05-15 | Dsm Nutritional Products Ag | Homogenized formulations containing microcapsules and methods of making and using thereof |
| WO2007120500A2 (en) * | 2006-04-07 | 2007-10-25 | Ocean Nutrition Canada Ltd. | Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof |
| EP2040682B1 (en) * | 2006-06-05 | 2017-07-26 | DSM Nutritional Products AG | Microcapsules with improved shells |
| EP2124905B1 (en) | 2007-01-10 | 2016-09-07 | DSM Nutritional Products AG | Microcapsules including pea protein |
| US20090018151A1 (en) * | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
| CA2981549A1 (en) * | 2009-01-27 | 2010-08-05 | Berg Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| SG10201404883YA (en) | 2009-08-14 | 2014-10-30 | Berg Llc | Vitamin d3 and analogs thereof for treating alopecia |
| WO2012158794A1 (en) | 2011-05-17 | 2012-11-22 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses |
| AU2014274099A1 (en) | 2013-05-29 | 2015-12-24 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin D |
| CN104926739B (zh) * | 2015-06-09 | 2017-06-27 | 南京理工大学 | 基于氮杂环修饰的维生素d2衍生物、合成及应用 |
| US10548908B2 (en) | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3276167D1 (en) * | 1981-11-02 | 1987-06-04 | Res Inst Medicine Chem | Intermediates in the synthesis of vitamin d derivatives |
| DE4141746A1 (de) * | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them |
| US5446635A (en) * | 1993-06-24 | 1995-08-29 | Quarton, Inc. | Laser assembly for marking a line on a workpiece for guiding a cutting tool |
-
1993
- 1993-07-23 GB GB939315253A patent/GB9315253D0/en active Pending
-
1994
- 1994-07-22 IL IL11041594A patent/IL110415A/xx not_active IP Right Cessation
- 1994-07-22 DK DK94921070T patent/DK0710227T3/da active
- 1994-07-22 HU HU9600136A patent/HU221597B/hu not_active IP Right Cessation
- 1994-07-22 ES ES94921070T patent/ES2125466T3/es not_active Expired - Lifetime
- 1994-07-22 DE DE69414115T patent/DE69414115T2/de not_active Expired - Fee Related
- 1994-07-22 NZ NZ268659A patent/NZ268659A/en unknown
- 1994-07-22 CN CN94193108A patent/CN1043883C/zh not_active Expired - Fee Related
- 1994-07-22 AU AU71939/94A patent/AU690565B2/en not_active Ceased
- 1994-07-22 JP JP7505021A patent/JPH09500637A/ja not_active Ceased
- 1994-07-22 CA CA002167837A patent/CA2167837A1/en not_active Abandoned
- 1994-07-22 WO PCT/GB1994/001587 patent/WO1995003273A1/en not_active Application Discontinuation
- 1994-07-22 KR KR1019960700344A patent/KR100321415B1/ko not_active IP Right Cessation
- 1994-07-22 US US08/537,869 patent/US5872140A/en not_active Expired - Fee Related
- 1994-07-22 AT AT94921070T patent/ATE172451T1/de not_active IP Right Cessation
- 1994-07-22 EP EP94921070A patent/EP0710227B1/en not_active Expired - Lifetime
- 1994-07-22 ZA ZA945427A patent/ZA945427B/xx unknown
- 1994-07-22 CZ CZ96207A patent/CZ20796A3/cs unknown
-
1996
- 1996-01-22 FI FI960303A patent/FI113535B/fi not_active IP Right Cessation
- 1996-01-22 NO NO19960251A patent/NO314453B1/no not_active IP Right Cessation
-
1998
- 1998-10-20 US US09/175,311 patent/US6013814A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2167837A1 (en) | 1995-02-02 |
| CN1043883C (zh) | 1999-06-30 |
| FI960303A (fi) | 1996-03-22 |
| HU9600136D0 (en) | 1996-03-28 |
| DK0710227T3 (da) | 1999-06-28 |
| WO1995003273A1 (en) | 1995-02-02 |
| DE69414115D1 (de) | 1998-11-26 |
| NO960251L (no) | 1996-03-22 |
| HU221597B (hu) | 2002-11-28 |
| GB9315253D0 (en) | 1993-09-08 |
| AU7193994A (en) | 1995-02-20 |
| ATE172451T1 (de) | 1998-11-15 |
| CN1129441A (zh) | 1996-08-21 |
| US5872140A (en) | 1999-02-16 |
| ES2125466T3 (es) | 1999-03-01 |
| NO960251D0 (no) | 1996-01-22 |
| KR100321415B1 (ko) | 2002-11-13 |
| IL110415A0 (en) | 1996-03-31 |
| EP0710227B1 (en) | 1998-10-21 |
| ZA945427B (en) | 1995-08-24 |
| JPH09500637A (ja) | 1997-01-21 |
| NZ268659A (en) | 1996-09-25 |
| CZ20796A3 (en) | 1996-10-16 |
| EP0710227A1 (en) | 1996-05-08 |
| IL110415A (en) | 2000-01-31 |
| HUT73846A (en) | 1996-09-30 |
| AU690565B2 (en) | 1998-04-30 |
| DE69414115T2 (de) | 1999-04-08 |
| NO314453B1 (no) | 2003-03-24 |
| US6013814A (en) | 2000-01-11 |
| FI113535B (fi) | 2004-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |