FI960303A - D-vitamiinianalogeja - Google Patents
D-vitamiinianalogeja Download PDFInfo
- Publication number
- FI960303A FI960303A FI960303A FI960303A FI960303A FI 960303 A FI960303 A FI 960303A FI 960303 A FI960303 A FI 960303A FI 960303 A FI960303 A FI 960303A FI 960303 A FI960303 A FI 960303A
- Authority
- FI
- Finland
- Prior art keywords
- alpha
- azide
- optionally substituted
- group
- vitamin
- Prior art date
Links
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 150000001540 azides Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- -1 cyclohexylidene moiety Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9315253 | 1993-07-23 | ||
| GB939315253A GB9315253D0 (en) | 1993-07-23 | 1993-07-23 | Chemical compounds |
| PCT/GB1994/001587 WO1995003273A1 (en) | 1993-07-23 | 1994-07-22 | Vitamin d analogues |
| GB9401587 | 1994-07-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI960303A0 FI960303A0 (fi) | 1996-01-22 |
| FI960303A true FI960303A (fi) | 1996-03-22 |
| FI113535B FI113535B (fi) | 2004-05-14 |
Family
ID=10739292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI960303A FI113535B (fi) | 1993-07-23 | 1996-01-22 | Menetelmä terapeuttisesti käyttökelpoisten D-vitamiinianalogien valmistamiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5872140A (fi) |
| EP (1) | EP0710227B1 (fi) |
| JP (1) | JPH09500637A (fi) |
| KR (1) | KR100321415B1 (fi) |
| CN (1) | CN1043883C (fi) |
| AT (1) | ATE172451T1 (fi) |
| AU (1) | AU690565B2 (fi) |
| CA (1) | CA2167837A1 (fi) |
| CZ (1) | CZ20796A3 (fi) |
| DE (1) | DE69414115T2 (fi) |
| DK (1) | DK0710227T3 (fi) |
| ES (1) | ES2125466T3 (fi) |
| FI (1) | FI113535B (fi) |
| GB (1) | GB9315253D0 (fi) |
| HU (1) | HU221597B (fi) |
| IL (1) | IL110415A (fi) |
| NO (1) | NO314453B1 (fi) |
| NZ (1) | NZ268659A (fi) |
| WO (1) | WO1995003273A1 (fi) |
| ZA (1) | ZA945427B (fi) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6703380B2 (en) | 1999-09-29 | 2004-03-09 | Colotech A/S | Prevention of cancer |
| DK1220676T3 (da) | 1999-09-29 | 2005-09-05 | Colotech As | Forebyggelse af colorektal cancer |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6555573B2 (en) * | 2000-12-21 | 2003-04-29 | The Quigley Corporation | Method and composition for the topical treatment of diabetic neuropathy |
| US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| US20030105031A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Methods for the treatment of skin disorders |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030118536A1 (en) * | 2001-11-06 | 2003-06-26 | Rosenbloom Richard A. | Topical compositions and methods for treatment of adverse effects of ionizing radiation |
| US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
| DK1575561T3 (da) * | 2002-11-04 | 2010-09-20 | Ocean Nutrition Canada Ltd | Mikrokapsel med flere kapper og fremgangsmåde til fremstilling heraf |
| US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
| US8034450B2 (en) * | 2005-01-21 | 2011-10-11 | Ocean Nutrition Canada Limited | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
| DE602006011127D1 (de) * | 2005-01-27 | 2010-01-28 | Ocean Nutrition Canada Ltd | Fettsäure-benzenediol-derivate sowie herstellungs- und verwendungsverfahren dafür |
| EP1848729A2 (en) * | 2005-01-27 | 2007-10-31 | Ocean Nutrition Canada Limited | Chromium-fatty acid compounds and methods of making and using thereof |
| US9968120B2 (en) * | 2006-05-17 | 2018-05-15 | Dsm Nutritional Products Ag | Homogenized formulations containing microcapsules and methods of making and using thereof |
| JP2009533490A (ja) * | 2006-04-07 | 2009-09-17 | オーシャン ニュートリッション カナダ リミテッド | 低い界面張力を有する物質を含む乳濁液およびマイクロカプセル、ならびにそれらを作製および使用する方法 |
| KR101994513B1 (ko) * | 2006-06-05 | 2019-06-28 | 디에스엠 뉴트리셔널 프라덕츠 아게 | 개선된 쉘을 가지는 마이크로캡슐 |
| AU2008205325B2 (en) | 2007-01-10 | 2013-09-12 | Dsm Nutritional Products Ag | Vegetarian microcapsules |
| US20090018151A1 (en) * | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
| SG173119A1 (en) * | 2009-01-27 | 2011-08-29 | Berg Biosystems Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| BR112012003372A2 (pt) | 2009-08-14 | 2019-09-24 | Berg Biosystems Llc | vitamina d3 e análogos da mesma para o tratamento de alopecia. |
| WO2012158794A1 (en) | 2011-05-17 | 2012-11-22 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses |
| EP3003497B1 (en) | 2013-05-29 | 2024-02-14 | BPGbio, Inc. | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| CN104926739B (zh) * | 2015-06-09 | 2017-06-27 | 南京理工大学 | 基于氮杂环修饰的维生素d2衍生物、合成及应用 |
| US10548908B2 (en) | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2114570B (en) * | 1981-11-02 | 1985-08-07 | Res Inst Medicine Chem | Chemical compounds |
| DE4141746A1 (de) * | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them |
| US5446635A (en) * | 1993-06-24 | 1995-08-29 | Quarton, Inc. | Laser assembly for marking a line on a workpiece for guiding a cutting tool |
-
1993
- 1993-07-23 GB GB939315253A patent/GB9315253D0/en active Pending
-
1994
- 1994-07-22 IL IL11041594A patent/IL110415A/xx not_active IP Right Cessation
- 1994-07-22 CA CA002167837A patent/CA2167837A1/en not_active Abandoned
- 1994-07-22 ZA ZA945427A patent/ZA945427B/xx unknown
- 1994-07-22 DK DK94921070T patent/DK0710227T3/da active
- 1994-07-22 CZ CZ96207A patent/CZ20796A3/cs unknown
- 1994-07-22 DE DE69414115T patent/DE69414115T2/de not_active Expired - Fee Related
- 1994-07-22 HU HU9600136A patent/HU221597B/hu not_active IP Right Cessation
- 1994-07-22 NZ NZ268659A patent/NZ268659A/en unknown
- 1994-07-22 AU AU71939/94A patent/AU690565B2/en not_active Ceased
- 1994-07-22 US US08/537,869 patent/US5872140A/en not_active Expired - Fee Related
- 1994-07-22 AT AT94921070T patent/ATE172451T1/de not_active IP Right Cessation
- 1994-07-22 JP JP7505021A patent/JPH09500637A/ja not_active Ceased
- 1994-07-22 EP EP94921070A patent/EP0710227B1/en not_active Expired - Lifetime
- 1994-07-22 WO PCT/GB1994/001587 patent/WO1995003273A1/en not_active Application Discontinuation
- 1994-07-22 KR KR1019960700344A patent/KR100321415B1/ko not_active IP Right Cessation
- 1994-07-22 CN CN94193108A patent/CN1043883C/zh not_active Expired - Fee Related
- 1994-07-22 ES ES94921070T patent/ES2125466T3/es not_active Expired - Lifetime
-
1996
- 1996-01-22 FI FI960303A patent/FI113535B/fi not_active IP Right Cessation
- 1996-01-22 NO NO19960251A patent/NO314453B1/no not_active IP Right Cessation
-
1998
- 1998-10-20 US US09/175,311 patent/US6013814A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB9315253D0 (en) | 1993-09-08 |
| US6013814A (en) | 2000-01-11 |
| DE69414115T2 (de) | 1999-04-08 |
| KR100321415B1 (ko) | 2002-11-13 |
| US5872140A (en) | 1999-02-16 |
| ATE172451T1 (de) | 1998-11-15 |
| NO960251D0 (no) | 1996-01-22 |
| JPH09500637A (ja) | 1997-01-21 |
| CN1043883C (zh) | 1999-06-30 |
| NO960251L (no) | 1996-03-22 |
| AU690565B2 (en) | 1998-04-30 |
| ES2125466T3 (es) | 1999-03-01 |
| IL110415A (en) | 2000-01-31 |
| CA2167837A1 (en) | 1995-02-02 |
| AU7193994A (en) | 1995-02-20 |
| CN1129441A (zh) | 1996-08-21 |
| NO314453B1 (no) | 2003-03-24 |
| IL110415A0 (en) | 1996-03-31 |
| CZ20796A3 (en) | 1996-10-16 |
| FI113535B (fi) | 2004-05-14 |
| FI960303A0 (fi) | 1996-01-22 |
| ZA945427B (en) | 1995-08-24 |
| DK0710227T3 (da) | 1999-06-28 |
| NZ268659A (en) | 1996-09-25 |
| EP0710227A1 (en) | 1996-05-08 |
| HU9600136D0 (en) | 1996-03-28 |
| DE69414115D1 (de) | 1998-11-26 |
| HUT73846A (en) | 1996-09-30 |
| EP0710227B1 (en) | 1998-10-21 |
| WO1995003273A1 (en) | 1995-02-02 |
| HU221597B (hu) | 2002-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |