ITMI931808A1 - Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico - Google Patents

Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico

Info

Publication number
ITMI931808A1
ITMI931808A1 IT93MI001808A ITMI931808A ITMI931808A1 IT MI931808 A1 ITMI931808 A1 IT MI931808A1 IT 93MI001808 A IT93MI001808 A IT 93MI001808A IT MI931808 A ITMI931808 A IT MI931808A IT MI931808 A1 ITMI931808 A1 IT MI931808A1
Authority
IT
Italy
Prior art keywords
oxymic
derivatives
formylphenylacetamide
cephalosporanic acid
acid
Prior art date
Application number
IT93MI001808A
Other languages
English (en)
Inventor
Riccardo Colombo
Original Assignee
Hi Chem S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hi Chem S P A filed Critical Hi Chem S P A
Publication of ITMI931808A0 publication Critical patent/ITMI931808A0/it
Priority to ITMI931808A priority Critical patent/IT1271404B/it
Priority to IL11029094A priority patent/IL110290A/en
Priority to AU68611/94A priority patent/AU674967B2/en
Priority to CA002128557A priority patent/CA2128557A1/en
Priority to US08/281,170 priority patent/US5574153A/en
Priority to EP94111843A priority patent/EP0638574A1/en
Priority to ZA945739A priority patent/ZA945739B/xx
Priority to CN94109525A priority patent/CN1118349A/zh
Priority to KR1019940019447A priority patent/KR950005831A/ko
Priority to RU94028649/04A priority patent/RU94028649A/ru
Priority to FI943676A priority patent/FI943676A/fi
Priority to JP6187518A priority patent/JPH07179473A/ja
Publication of ITMI931808A1 publication Critical patent/ITMI931808A1/it
Application granted granted Critical
Publication of IT1271404B publication Critical patent/IT1271404B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Vengono descritti derivati ossimici dell'acido formilfenilacetamidocefalosporanico sostituiti in posizione 3 con un radicale alchilico sostituito o con un radicale alchenile. I composti (I) presentano una interessante attività antimicrobica ad ampio spettro.
ITMI931808A 1993-08-09 1993-08-09 Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico IT1271404B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITMI931808A IT1271404B (it) 1993-08-09 1993-08-09 Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico
IL11029094A IL110290A (en) 1993-08-09 1994-07-12 History of oxen of Cephalosporan structure and their preparation
AU68611/94A AU674967B2 (en) 1993-08-09 1994-07-20 Oxime derivatives of cephalosporanic structure and compounds for their preparation
CA002128557A CA2128557A1 (en) 1993-08-09 1994-07-21 Oxime derivatives of cephalosporanic structure and compounds for their preparation
US08/281,170 US5574153A (en) 1993-08-09 1994-07-27 Oxime derivatives of cephalosporanic structure
EP94111843A EP0638574A1 (en) 1993-08-09 1994-07-29 Oxime derivatives of cephalosporanic structure and compounds for their preparation
ZA945739A ZA945739B (en) 1993-08-09 1994-08-02 Oxime derivatives of cephalosporanic structure and compounds for their preparation
CN94109525A CN1118349A (zh) 1993-08-09 1994-08-08 头孢菌素结构的肟衍生物以及化合物的制备
KR1019940019447A KR950005831A (ko) 1993-08-09 1994-08-08 세팔로스포란성 구조의 옥심 유도체 및 이를 제조하기 위한 화합물
RU94028649/04A RU94028649A (ru) 1993-08-09 1994-08-08 Оксимные производные с цефалоспорановой структурой, способ их получения и промежуточные соединения
FI943676A FI943676A (fi) 1993-08-09 1994-08-09 Oksiimijohdannaiset, joilla on kefalosporaanirakenne ja yhdisteet niiden valmistamiseksi
JP6187518A JPH07179473A (ja) 1993-08-09 1994-08-09 セファロスポラン酸構造を有するオキシム誘導体およびその製造用化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI931808A IT1271404B (it) 1993-08-09 1993-08-09 Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico

Publications (3)

Publication Number Publication Date
ITMI931808A0 ITMI931808A0 (it) 1993-08-09
ITMI931808A1 true ITMI931808A1 (it) 1995-02-09
IT1271404B IT1271404B (it) 1997-05-28

Family

ID=11366805

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI931808A IT1271404B (it) 1993-08-09 1993-08-09 Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico

Country Status (12)

Country Link
US (1) US5574153A (it)
EP (1) EP0638574A1 (it)
JP (1) JPH07179473A (it)
KR (1) KR950005831A (it)
CN (1) CN1118349A (it)
AU (1) AU674967B2 (it)
CA (1) CA2128557A1 (it)
FI (1) FI943676A (it)
IL (1) IL110290A (it)
IT (1) IT1271404B (it)
RU (1) RU94028649A (it)
ZA (1) ZA945739B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006007882A1 (de) * 2006-02-21 2007-08-30 Bayer Cropscience Ag Cycloalkyl-phenylsubstituierte cyclische Ketoenole
EP2346814A2 (en) * 2008-10-27 2011-07-27 Cadila Healthcare Limited Thyroid receptor ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492297A (en) * 1965-07-01 1970-01-27 Merck & Co Inc Guanidino cephalosporins
BE790093A (fr) * 1971-10-14 1973-04-13 R & L Procede pour preparer des agents antibacteriens
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds
FR2642422A1 (fr) * 1988-12-22 1990-08-03 Roussel Uclaf Nouvelles polyamines acylees, leur procede de preparation et leur application comme fongicides
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5095107A (en) * 1990-11-05 1992-03-10 Eli Lilly And Company Process for cleavage of esters during the production of cephalosporins

Also Published As

Publication number Publication date
JPH07179473A (ja) 1995-07-18
CA2128557A1 (en) 1995-02-10
US5574153A (en) 1996-11-12
CN1118349A (zh) 1996-03-13
ITMI931808A0 (it) 1993-08-09
EP0638574A1 (en) 1995-02-15
AU6861194A (en) 1995-02-16
ZA945739B (en) 1995-05-11
IL110290A (en) 1998-08-16
KR950005831A (ko) 1995-03-20
RU94028649A (ru) 1996-06-20
IT1271404B (it) 1997-05-28
FI943676A0 (fi) 1994-08-09
IL110290A0 (en) 1994-10-21
FI943676A (fi) 1995-02-10
AU674967B2 (en) 1997-01-16

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Effective date: 19970829